Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Immunosuppressive effects of Ovalicin-semicarbazone (1974)
    Springer
    Inflammation research 4 (1974), S. 357-363 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Ovalicin-semicarbazone suppresses antibody-formation in mice and in other species as measured in the plaque-forming cell and haemagglutination tests. It further impairs cell-mediated immunity as assayed by: homograft reaction and immune cytolysis of tumour target cells in mice, experimental allergic encephalomyelitis in rats, and the tuberculin reaction in guinea-pigs. Although spleen weights are decreased in Ovalicin-semicarbazone treated animals, bone marrow inhibition (as measured by peripheral leukocyte and thrombocyte counts) is only moderate after repeated administration of immunosuppressive doses. Recovery of haemopoietic functions occurs soon after cessation of treatment. The effects of Ovalicinsemicarbazone are compared with those of Ovalicin and azathioprine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01964937
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Biological effects of cyclosporin A: A new antilymphocytic agent (1994)
    Springer
    Inflammation research 43 (1994), S. 179-186 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. It strongly depressed appearance of both direct and indirect plaque-forming cells and produced a clear dose-dependent inhibition of haemagglutinin formation in mice upon oral administration. Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cyclosporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. This compound was not only highly effective in preventing development of Freund's adjuvant arthritis, but in addition improved the symptoms in rats with established arthritis, although it is inactive in acute inflammation. This new agent contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity. Experimental evidence suggests that cyclosporin A, rather than being cytostatic or lympholytic, affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01986686
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    The effects of fractions (chalones) obtained from lymphoid organs on the immune response in vivo (1978)
    Springer
    Inflammation research 8 (1978), S. 523-531 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aqueous extracts of calf and pig lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing. These fractions, which had been previously assessed on mitogen-stimulated mouse spleen lymphocytes and other cells in vitro, were tested for their in vivo activity on humoral (haemolytic PFC in mice) and on cell-mediated immunity (skin allograft survival in mice, lymph node weight assay in rats, and systemic GvH-reaction in mice). None of these several fractions elicited either biologically significant or reproducible inhibitory effects. In particular, two fractions, a high and a small molecular weight fraction which were strongly inhibitory in vitro, remained without any chalone-like activity in these in vivo assays. Our results therefore failed to support the existence of a lymphocyte chalone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02111440
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Biological effects of cyclosporin A: A new antilymphocytic agent (1976)
    Springer
    Inflammation research 6 (1976), S. 468-475 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The fungus metabolite cyclosporin A is a small peptide acting as a novel antilymphocytic agent. It strongly depressed appearance of both direct and indirect plaque-forming cells and produced a clear dose-dependent inhibition of haemagglutinin formation in mice upon oral administration. Skin graft rejection in mice and graft-versus-host disease in mice and rats were considerably delayed by cyclosporin A which also prevented the occurrence of paralysis in rats with experimental allergic encephalomyelitis. This compound was not only highly effective in preventing development of Freund's adjuvant arthritis, but in addition improved the symptoms in rats with established arthritis, although it is inactive in acute inflammation. This new agent contrasts with other immunosuppressives and cytostatic drugs in its weak myelotoxicity. Experimental evidence suggests that cyclosporin A, rather than being cytostatic or lympholytic, affects an early stage of mitogenic triggering of the immunocompetent lymphoid cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01973261
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    The effects of fractions (Chalones) obtained from lymphoid organs on lymphocyte proliferation in vitro (1977)
    Springer
    Inflammation research 7 (1977), S. 327-335 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aqueous extracts of lymphoid organs were prepared and fractionated by means of gel filtration, ion exchange chromatography, and isoelectric focusing. A protein-containing fraction with a molecular weight of approximately 80,000–90,000 and isoelectric points of 7.6 and 5.3–6.2 was isolated and shown to inhibit reproducibly both thymidine incorporation and proliferation of concanavalin A-stimulated mouse spleen lymphocytes in vitro. This effect appeared specific, since proliferation of mastocytoma P-815 and leukemia L-1210 cells remained unaffected. A small molecular weight fraction (500 to 10,000 daltons) was also found to inhibit lymphocyte proliferation in vitro but was without apparent specificity for cell type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01969564
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Cyclosporin A: Effects on the mouse thymus (1981)
    Springer
    Inflammation research 11 (1981), S. 373-379 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Cyclosporin A (CY-A), an immunosuppressive cyclic endecapeptide, causes thymus weight reduction in mice 4 days after single oral administration. This effect was compared with that of hydrocortisone acetate (HCA), or of azathioprine (AZ). The latter had no effect on thymus weight, whereas HCA induced a marked reduction 2 days after administration. A possible mediation by the pituitary adrenal gland system (PAG) of the CY-A induced effect was suggested by the observation of an elevated corticosterone plasma level after CY-A administration and by the prevention of the thymocytolytic effect by adrenalectomy. However, the immunosuppressive activity of CY-A in humoral immunity and cell mediated immunity tests was not affected by adrenalectomy. It must therefore be concluded that the immunosuppression produced by CY-A in vivo is not mediated by stimulation of the PAG system, contrary to its effect on the mouse thymus, which is a glucocorticosteroid effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01982473
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 7
    Electronic Resource
    Electronic Resource
    Suppression of DTH mediated by cloned helper T cells with ciclosporin and dexamethasone (1986)
    Springer
    Inflammation research 19 (1986), S. 280-281 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01971229
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 8
    Electronic Resource
    Electronic Resource
    Antiarthritic and immunosuppressive effects of Pseudomonas aeruginosa (1972)
    Springer
    Inflammation research 2 (1972), S. 231-235 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fractions obtained from Pseudomonas aeruginosa suppressed microcrystal synovitis in pigeons, adjuvant arthritis and experimental allergic encephalomyelitis in rats, the tuberculin reaction in guinea-pigs and the homograft reaction and antibody formation in mice. Products of gram-negative bacteria thus impair nonimmunological inflammatory processes as well as in vivo manifestations of immune-mediated reactions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02087047
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 9
    Electronic Resource
    Electronic Resource
    Macrophage and Neutrophil Specific Chemotactic Factors in Serum (1969)
    [s.l.] : Nature Publishing Group
    Nature 222 (1969), S. 244-247 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Factors present in normal rabbit serum induce adirectional migration of neutrophils and macrophages. The movement of neutrophils is enhanced by the addition of antigen–antibody complex to the serum, while the movement of macrophages is depressed. A complex pattern of synergism and inhibition ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/222244a0
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 10
    Electronic Resource
    Electronic Resource
    Cyclosporine as a New Approach to Therapy of Autoimmune Diseases (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 475 (1986), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1986.tb20879.x
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...