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  • 1
    Electronic Resource
    Electronic Resource
    Effect of naloxone administration upon responses of adrenal hormones to withdrawal from ethanol (1984)
    Springer
    Psychopharmacology 82 (1984), S. 181-184 
    Details
    ISSN: 1432-2072
    Keywords: Corticosterone ; Adrenal catecholamine ; Ethanol ; Withdrawal ; Naloxone ; Stress ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats maintained on an ethanol-liquid diet developed physical dependence after 16 days. Activation of adrenocortical function and overactivity of the sympathoadrenal system were observed during withdrawal from ethanol. The opiate antagonist naloxone prevented the adrenomedullary response, and attenuated, though not significantly, the increases in serum corticosterone induced by ethanol deprivation. These findings suggest that endogenous opioid pathways may be involved in the ethanol-withdrawal syndrome.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427769
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of acute and chronic administration of morphine on the turnover of brain and adrenal catecholamines in rats (1980)
    Springer
    Psychopharmacology 68 (1980), S. 43-49 
    Details
    ISSN: 1432-2072
    Keywords: Catecholamines ; Turnover ; Brain ; Adrenal glands ; Morphine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Brain and adrenal catecholamine turnover in adult female rats treated with morphine was investigated. A different time course response of brain and adrenal catecholamines to α-methyl-p-tyrosine methylester (AMT) administration in normal rats was observed; the catecholamine turnover rate in adrenal glands appeared to be much slower than in the brain. Acute morphine increased the turnover of brain dopamine and noradrenaline as well as of adrenal catecholamines, whereas chronic morphine treatment induced a decrease in the turnover of brain noradrenaline. Withdrawal induced by nalorphine produced an increase in the utilization of brain noradrenaline and adrenal catecholamines; this effect could be related to the withdrawal stress situation induced by the opiate antagonist. Although the mechanism of morphine action may implicate other neurotransmitters besides catecholamines, our results contribute to evidence that brain and adrenal catecholamines could be involved in the mechanism of morphine tolerance and/or dependence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426648
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Adrenocortical response to acute and chronic ethanol administration in rats (1983)
    Springer
    Psychopharmacology 79 (1983), S. 173-176 
    Details
    ISSN: 1432-2072
    Keywords: Corticosterone ; Ethanol ; Acute and chronic ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute ethanol administration (2 g/kg IP) induced a significant rise in serum corticosterone levels which seemed to be related to blood ethanol concentration. Chronic ethanol administration, in the form of a liquid diet for 16 or 30 days, did not alter the levels of serum corticosterone. Chronic treatment of rats with a liquid diet containing ethanol resulted in the development of tolerance.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427806
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Effects of adrenaline on the acquisition and maintenance of ethanol preference in a taste conditioning paradigm (1986)
    Springer
    Psychopharmacology 90 (1986), S. 336-340 
    Details
    ISSN: 1432-2072
    Keywords: Adrenaline ; Taste paradigm ; Ethanol preference ; Rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of subcutaneous adrenaline administration on preference for ethanol (2.5% solution) have been investigated, using a two-bottle choice situation. Administration of the amine (50 μg/kg) immediately after the conditioning session significantly attenuated ethanol preference. Adrenaline treatment (10, 50 or 100 μg/kg) prior to the first retention test induced a significant reduction in ethanol preference. When the amine was injected prior to conditioning only the dose of 100 μg/kg reduced later ethanol preference. Our results indicate that systemically administered adrenaline impairs the acquisition of preference to a weak ethanol solution. It is suggested that this effect of the amine may be linked to interference with consolidation of memory and retrieval processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00179187
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    Paper (German National Licenses)
    Fulltext
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