ISSN:
1662-0356
Source:
Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
Topics:
Natural Sciences in General
,
Technology
Notes:
Single-cell analysis is a very important field of research and is currently at the frontier ofphysical and biological sciences. Understanding how the phenotype of a single-cell arises from itsgenotype is a complex topic. Currently, the prevailing paradigm to analyze cellular functions is thestudy of biochemical interactions using fluorescence based imaging systems. However, theelimination of the labelling process is highly desirable to improve the accuracy of the analysis.Living cells are electromagnetic units; in as much they use electric mechanisms to control andregulate dynamic processes involved in inter alia signal transduction, metabolism, proliferation anddifferentiation. Recent developments in micro- and nanofabrication technologies are offering greatopportunities for the analysis of single cells; the combination of micro fluidic environments, nanoelectrodes/wires and ultra wide band electromagnetic engineering will soon make possible theinvestigation of local (submicrometer scale) dynamic processes integrating several events atdifferent time scales. In the paper, we present recent approaches which aim at investigating singlecellswith the help of MEMS and NEMS (Micro and Nano Electro Mechanical Systems) and ultrawide band (DC-THz) electromagnetic characterization techniques
Type of Medium:
Electronic Resource
URL:
http://www.tib-hannover.de/fulltexts/2011/0528/01/42/transtech_doi~10.4028%252Fwww.scientific.net%252FAST.53.97.pdf
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