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  • 1
    Electronic Resource
    Electronic Resource
    Acid Monoamine Metabolites in Cerebrospinal Fluid during Methadone Maintenance (1971)
    [s.l.] : Nature Publishing Group
    Nature 232 (1971), S. 581-582 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Twenty-five determinations were made in sixteen male (ages 25-46) and five female (ages 25-32) heroin addicts who were taking single daily doses of methadone (25-135 mg/day). For ten determinations, 4 ml. CSF was obtained by lumbar tap while a group of subjects was taking methadone only. Before ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/232581a0
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  • 2
    Electronic Resource
    Electronic Resource
    Relationship of Monoamine Metabolites in Human Cerebrospinal Fluid to Age (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 1256-1257 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Lumbar punctures were performed between 10 days and 2 weeks after admission in thirty male and female psychiatric patients: nine schizophrenics, seven manic depressives and fourteen depressives. Diagnoses were agreed on by two staff psychiatrists. No patients had received medication since their ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2191256a0
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  • 3
    Electronic Resource
    Electronic Resource
    Methadone increases Mouse Brain 5-Hydroxyindoleacetic Acid (1971)
    [s.l.] : Nature Publishing Group
    Nature 229 (1971), S. 134-135 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 5-Hydroxyindoleacetic Acid Content of Mouse Brain after Administration of Methadone or Morphine Brain 5HIAA as Drug regimen percentage change from control* (1) Morphine 10 mg/kg 3 times daily for 1 week, then 20 mg/kg 3 times daily for 2 weeks +111 (4) (2) Methadone 10 mg/kg 3 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/229134a0
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  • 4
    Electronic Resource
    Electronic Resource
    Regional homovanillic acid levels and oral movements in rats following chronic haloperidol treatment (1989)
    Springer
    Psychopharmacology 98 (1989), S. 430-431 
    Details
    ISSN: 1432-2072
    Keywords: Haloperidol ; Dopamine ; Oral movements ; Rat ; Tardive dyskinesia ; Homovanillic acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Rats with more severe orofacial movements after 51 days of haloperidol administration showed lower levels of the dopamine metabolite homovanillic acid (HVA) in the caudate compared to animals who did not develop significant mouth movements. This effect was not observed in other brain regions sampled. This finding is consistent with the hypothesis that dopaminergic receptor supersensitivity in neostriatal structures plays some role in the development of orofacial movements in rats, in association with chronic neuroleptic administration.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00451700
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  • 5
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid 5-hydroxyindoleacetic acid (5HIAA) and homovanillic acid (HVA) following probenecid in unipolar depressives treated with amitriptyline (1972)
    Springer
    Psychopharmacology 23 (1972), S. 26-33 
    Details
    ISSN: 1432-2072
    Keywords: Cerebrospinal Fluid ; 5-Hydroxyindoleacetic Acid ; Homovanillic Acid ; Depression ; Amitriptyline ; Probenecid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lumbar cerebrospinal fluid 5-HIAA, HVA, and the ratio 5-HIAA/HVA were measured followed probenecid administration in eleven patints with unipolar depression before and during treatment with amitriptyline (AMI). Control values were obtained from a group of inmate volunteers. Prior to treatment CSF 5HIAA formation in the depressives was not different from controls. During treatment with AMI, CSF 5-HIAA formation decreased. One patient with psychotic symptoms prior to AMI and two patients who developed psychotic reactions on AMI showed relatively low CSF 5HIAA formation prior to antidepressant therapy. Compared to controls CSF HVA values were higher in the depressives prior to AMI therapy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00414411
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  • 6
    Electronic Resource
    Electronic Resource
    REM sleep and central monoamine oxidase inhibition (1972)
    Springer
    Psychopharmacology 27 (1972), S. 183-190 
    Details
    ISSN: 1432-2072
    Keywords: Cerebrospinal Fluid ; 5-Hydroxyindoleacetic Acid ; Homovanillic Acid ; Dopamine ; Depression ; REM Sleep ; Phenelzine ; Monoamine Oxidase Inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Our preliminary observations on the relationship of sleep and lumbar CSF acid monoamine metabolite levels suggested a greater decrease in lumbar CSF HVA as compared to 5HIAA following clinical doses of phenelzine in the presence of virtually total REM suppression. This report on nine psychiatric patients confirms these findings in a larger sample and thus supports an inhibitory role for dopamine or other catecholamines in REM sleep mechanisms. The drug-withdrawal results indicate that the four patients with REM rebound showed increases in HVA levels compared to treatment levels, while the single patient with no REM rebound also had no increase in HVA levels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422798
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  • 7
    Electronic Resource
    Electronic Resource
    Tardive dyskinesia: A clinical test of the supersensitivity hypothesis (1979)
    Springer
    Psychopharmacology 61 (1979), S. 137-141 
    Details
    ISSN: 1432-2072
    Keywords: CSF cyclic AMP ; CSF homovanillic acid ; Tardive dyskinesia ; Dopamine receptor supersensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Patients with tardive dyskinesia showed no significant difference in CSF HVA when compared with groups of schizophrenic or depressives. CSF cAMP in the tardive dyskinesia group was significantly lower when compared to schizophrenics but not depressives. These results do not support a dopamine-receptor supersensitivity hypothesis in permanent tardive dyskinesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426727
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  • 8
    Electronic Resource
    Electronic Resource
    Cerebrospinal fluid homovanillic acid and hypokinetic side effects of neuroleptics (1985)
    Springer
    Psychopharmacology 85 (1985), S. 184-186 
    Details
    ISSN: 1432-2072
    Keywords: Cerebrospinal fluid ; Homovanillic acid ; Catatonia ; Parkinsonian side effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Eleven psychotic patients treated with neuroleptics for 1 month showed a relatively poor response, more side effects, and a no-tolerance pattern with respect to cerebrospinal fluid (CSF) homovanillic acid (HVA). Within this group the severity of neuroleptic catatonia and Parkinsonian side effects was positively associated with an increase in CSF HVA turnover during the treatment period.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428411
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  • 9
    Electronic Resource
    Electronic Resource
    Homovanillic acid in caudate and pre-frontal cortex following acute and chronic neuroleptic administration (1986)
    Springer
    Psychopharmacology 88 (1986), S. 63-65 
    Details
    ISSN: 1432-2072
    Keywords: Pre-frontal cortex ; Homovanillic acid ; Neuroleptics ; Tolerance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Homovanillic acid (HVA) was measured in rat caudate and pre-frontal cortex after single and repeated doses of several types of neuroleptic drugs. Twice daily administration of low or high doses of haloperidol, fluphenazine, or (-) sulpiride resulted in greater tolerance to the initial HVA increase in caudate compared to prefrontal cortex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310514
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  • 10
    Electronic Resource
    Electronic Resource
    5-Hydroxyindoleacetic acid (5 HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines (1973)
    Springer
    Psychopharmacology 28 (1973), S. 309-318 
    Details
    ISSN: 1432-2072
    Keywords: 5-Hydroxyindoleacetic Acid ; Homovanillic Acid ; CSF ; Psychosis ; Phenothiazines ; Probenecid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Lumbar CSF 5 HIAA and HVA were measured following probenecid administration in acute psychotic patients before and during treatment with phenothiazines. Patients with more classical schizophrenic symptoms had higher values for 5 HIAA/HVA than other psychotics, depressives, and inmate volunteers. Prior to treatment CSF 5 HIAA, but not HVA, correlated significantly with several clinical items related to psychotic disorganization. Phenothiazine treatment produced significant increases in CSF HVA which could not be correlated with the dose of antipsychotic or antiparkinson drugs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00422751
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