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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 45 (1996), S. 755-759 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Intrapulmonale Blutung ; Pulmonalarterienkatheter ; Perforation ; Tödliche Komplikationen ; Key words Intrapulmonary bleeding ; Pulmonary artery catheter ; Perforation ; Lethal complications
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Three cases are presented dealing with rare lethal complications during the insertion of pulmonary artery catheters (PAC). Complications resulting from catheter insertion have been reported on numerous occasions; we report further examples of inadequate insertion techniques. Case reports. Deviating from the recommended guidelines was presumably a significant factor in the development of fatal pulmonary bleeding. In the first case PAC-related perforation of the right ventricle resulting in cardiac tamponade was found at autopsy. Clinically, this perforation had not been noticed. A guidewire was allegedly employed during insertion. The diameter of the perforation (3 mm) suggests that either the balloon was deflated or the guidewire was used incautiously. In the second case during insertion the balloon was described as being inflated “after” reaching a wedge position. Considering this fact, catheter migration with perforation of a distal small artery was evident. Distal migration is more frequently associated with rupture of the pulmonary artery. In the third case we found a sequence of intimal lesions in the right main pulmonary artery and a segmental artery of the right lung. This high number of PAC-induced lesions is unusual and suggests inappropriate inflation technique. Conclusions. Based on our observations, we believe the low complication rate associated with PAC insertion has led to deviations from the normal guidelines by some physicians. Despite adequate precautions and insertion technique, iatrogenic lesions cannot be avoided in all cases because of pre-existing risk factors. For the evaluation of catheter-induced complications and the development of a risk profile, more autopsies as well as more detailed clinical documentation would be necessary.
    Notes: Zusammenfassung Anhand von 3 Falldarstellungen wird über tödlich verlaufene Komplikationen beim Legen eines Pulmonalarterienkatheters berichtet. Während die pulmonale Blutung bei 2 Patientinnen (79 und 72 Jahre alt) kurz nach Entfernung des Katheters zum Tode führte, trat der Tod einer 55jährigen Patientin etliche Stunden nach dem Eingriff durch Herzbeuteltamponade nach Perforation der rechten Ventrikels ein. Die möglichen Mechanismen der tödlichen Komplikationen werden erörtert. Neben individuellen Prädispositionen aufgrund vorbestehender Erkrankungen existierten bei allen Fällen Hinweise, daß bei der Katheterisierung von den Richtlinien – u.a. auch der Hersteller – abgewichen wurde. Auch bestanden erhebliche Dokumentationslücken über den Eingriff, die die Klärung der Komplikationsursachen und die Erstellung eines Risikoprofils entscheidend beeinträchtigen. Eine detaillierte klinische Dokumentation des Eingriffs und, im Falle einer tödlichen Komplikation, die obligatorische Klassifikation als „nicht natürlicher Tod“ sind erforderlich.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Mathematische Annalen 292 (1992), S. 329-335 
    ISSN: 1432-1807
    Keywords: 14H42
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular evolution 41 (1995), S. 10-14 
    ISSN: 1432-1432
    Keywords: Microsatellite ; DNA polymorphism ; Primate phylogeny ; DNA sequencing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract We amplified, via PCR, DNA segments from intron 1 of the tyrosine hydroxylase gene (TH01) and intron 40 of the von Willebrand factor gene (VWA) in ten nonhuman primate genera. In humans both introns contain polymorphic microsatellites with tetrameric repeats. Compared to the allelic ranges in human populations relatively short repeat arrays could be detected for the nonhuman primates typed, presumably reflecting an ancient precursor state at both microsatellite loci. Furthermore, our results provide evidence for an association of the average number of repeats present in different primate genera and their divergence time from man. DNA sequencing of VWA orthologues revealed a relatively high variability in the arrangement of repeats in the 5′-repeat arrays, the generation of which could probably be explained by polar mutational events.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 98 (1996), S. 60-64 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract We have studied length and sequence variability at the HumD21S11 locus in five different populations to obtain more detailed information about the structure of this short tandem repeat system. In all populations studied so far two types of alleles have been described. The consensus alleles (type I) consist of three regions with variable numbers of TCTR units and one constant region comprising 43 bp. Alleles of type II (so-called interalleles) show the same basic sequence structure except for the occurrence of a TA insertion at a fixed position in variable region 3. Additional sequence variability exists in the Ovambo and Papuan populations with gross changes in two of the three variable regions and in the constant region. Due to these extreme variations the Ovambos and Papuans showed a better fit to the infinite allele model than to the stepwise mutation model. In the German, Japanese and Chinese populations no significant bias towards one of the two models could be observed. Population genetic studies showed no significant deviation from Hardy-Weinberg equilibrium.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0888-7543
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 16 (2002), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Alosetron reduces symptoms of dyspepsia, but the physiological basis for the symptomatic benefit is unclear.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To assess 5-HT3 antagonism on postprandial gastric volume and symptoms after ingestion of maximum tolerable volume of a liquid meal.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:In 36 healthy volunteers, we assessed effects of placebo, 0.5 and 1 mg b.d. alosetron on fasting and postprandial gastric volumes (using single photon emission computed tomography) and symptoms based on 100 mm VAS, 30 min after maximum volume ingested.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The 5-HT3 antagonist reduced postprandial symptoms (aggregate score: P 〈 0.05), nausea (P 〈 0.001), and tended to reduce bloating (P=0.08). Both 0.5 and 1 mg alosetron reduced nausea (P 〈 0.025); 1 mg alosetron reduced aggregate symptoms (P 〈 0.05) and bloating (P 〈 0.05). Effects on pain (P=0.19) and fullness (P=0.14) were not statistically significant. There were no significant effects of the 5-HT3 antagonist on volume of meal tolerated or on SPECT-measured fasting or postprandial gastric volumes.〈section xml:id="abs1-5"〉〈title type="main"〉Conclusion:5-HT3 antagonism reduces aggregate symptoms, nausea and bloating after a liquid meal without increase in gastric volumes, suggesting a role for 5-HT3 in afferent functions in healthy humans during the postprandial period.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 0022-4731
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Human Evolution 6 (1977), S. 131-133 
    ISSN: 0047-2484
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Description / Table of Contents: Zusammenfassung Allgemeine und spezielle Techniken zur Bestimmung von Serum-(Haptoglobin) und Erythrocytenenzym-Polymorphismen (SEP, PGM, Ak, ADA) mit Hilfe der horizontalen Polyacrylamidgel-Elektrophorese werden beschrieben. Im Vergleich zu Stärkegel-Techniken ergeben sich bestimmte Vorteile bei Verwendung von Polyacrylamid (PAA): 1. Verbesserte Trennung und Reproduzierbarkeit der Protein- und Enzymmuster. 2. Geringere Empfindlichkeit der PAA-Gele gegen Erhitzung und Austrocknung während der Elektrophorese. 3. PAA-Gele können bis zum Gebrauch gelagert werden. 4. PAA-Gele sind transparent und ermöglichen dadurch densitometrische Untersuchungen in durchfallendem Licht.
    Notes: Summary General and special procedures for the determination of serum (haptoglobin) and red cell enzyme polymorphisms by horizontal polyacrylamide (PAA) gel electrophoresis are given. As compared to starch gel techniques certain advantages could be established: 1. Improved separation and reproducibility of the patterns using PAA. 2. PAA gels are less sensitive to heating and desiccation during electrophoresis. 3. PAA gels can be stored prior to use. 4. PAA is transparent and enables densitometric studies using translucent light.
    Type of Medium: Electronic Resource
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