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  • 1
    ISSN: 1432-1084
    Keywords: Key words: Psoas haematoma ; Lumbar artery ; Spiral CT ; Embolization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. We report two cases of large spontaneous psoas haematoma in patients on anticoagulant therapy. Active bleeding was well demonstrated on spiral CT. Transcatheter arterial embolization was used successfully to stop bleeding. The diagnostic strategy, the relevance of spiral computed tomography and our therapeutic approach to this complication are discussed.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European biophysics journal 16 (1988), S. 207-218 
    ISSN: 1432-1017
    Keywords: Retinal rods ; phototransduction ; rhodopsin ; transducin ; light scattering
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Abstract The physical origin and functional significance of the near infra-red light scattering changes observable upon flash illumination of diluted suspensions of magnetically oriented, permeabilised frog retinal rods has been reinvestigated with particular attention paid to the degree with which transducin remains attached to the membrane. In the absence of GTP, the so called “binding” signal is shown to include two components of distinctive origins, widely different kinetics, and whose relative amplitudes depend on the dilution of the suspension and resulting detachment of transducin from the disc membrane. The fast component is a consequence of the fast interaction between photoexcited rhodopsin (R*) and the transducin remaining on the membrane. Its kinetics monitors a structural modification of the discs caused by a change in electrostatic interaction between closely packed membranes upon the formation of R*-T complexes. The slow component monitors the slow rebinding to the membrane and possible subsequent interaction with excess R* of T-GDP which, in spite of its low solubility, had eluted into solution given the high dilution of the permeated rods. In the presence of GTP, the so called “dissociation” signal includes a fast, anisotropic “release” component that specifically monitors the release into the interdiscal space of T α-GTP formed from the membrane-bound pool, and a slower isotropic “loss” component monitoring the leakage from the permeated rod of the excess T α-GTP which did not interact with the cGMP phosphodiesterase. The amplitudes of both components depend exclusively on the membrane bound T-GDP pool. The kinetics of the “loss” component is limited by the size and degree of permeation of the rod fragments, rather than by the dissociation rate of T α-GTP from the membrane.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 0898-6568
    Keywords: G-proteins ; Phototransduction ; phosphodiesterase ; transducin
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1615-6102
    Keywords: Rab7 protein ; Endocytosis ; Phagocytosis ; Lysosomal enzymes ; Cation-independent mannose 6-phosphate receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Small GTPases of the Rab subfamily localise to the cytoplasmic face of distinct membrane compartments and act as regulators of intracellular membrane traffic and transport vesicle formation. Among them, Rab7 controls the delivery of internalised material into degradative compartments and the acquisition of lysosomal hydrolases. This activity shapes the endocytic pathway of every cell type. In addition, this general role may adjust to serve specific needs in multicellular organisms.
    Type of Medium: Electronic Resource
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