Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    ISSN: 1432-1440
    Keywords: Renal osteodystrophy ; Child ; Metabolites of vitamin D ; Secondary hyperparathyroidism ; Renale Osteodystrophie ; Kind ; Vitamin-D-Metaboliten ; Sekundärer Hyperparathyreoidismus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung 1. Durch die Behandlung mit 1,25-DHCC gelingt es nach unseren Untersuchungsergebnissen einen Anstieg des Serumkalziumspiegels zu erhalten, die PTH-Synthese zu blockieren und die intestinale Kalziumresorption zu verbessern. 2. Die Fibroosteoclasie und die aktuellen Zeichen der Knochenresorption können unter der Therapie vollständig behoben bzw. verbessert werden. 3. Bei der Behandlung dialysierter Kinder mit 1,25-DHCC konnten wir eine Verbesserung der Osteoidose in Fällen mit erheblicher Mineralisationsstörung beobachten. 4. Die Zahl der Osteoblasten wird unter der Therapie erheblich reduziert, in den meisten Fällen beobachteten wir Werte im Bereich der unteren Norm oder niedriger. Dies bedeutet in Bezug auf eine Langzeittherapie die Reduktion der Knochenformation mit Gefahr der Osteopenie. 5. Die Entwicklung einer gefährlichen Hyperkalzämie bei gleichzeitiger Imbalance im Serumphosphathaushalt muß streng beachtet werden. Wir beobachteten aufgrund dieser Kalzium- und Phosphatstoffwechselstörungen erhebliche Kalzifikationen im Limbusbereich der Augen. 6. Aufgrund dieser Befunde sollte 1,25-DHCC individuell in niedriger Dosierung nur bei Kindern mit histologisch nachgewiesener schwerer renaler Osteodystrophie verwandt werden, sofern eine engmaschige kontinuierliche Überwachung sämtlicher Stoffwechselparameter möglich ist. 7. Eine Verbesserung des Körperwachstums konnte unter 1,25-DHCC-Behandlung nicht beobachtet werden.
    Notes: Summary Growth arrest and renal osteodystrophy are major problems in renal insufficiency of children. The present report describes our experiences in managing renal osteodystrophy in 14 dialyzed children using 1,25-DHCC for 12 months. Values in plasma of Ca, P, Mg, alkaline phosphatase, iPTH, 25-OH-D, and 1,25-DHCC were determined regulary. Skeletal X-rays and analysis of iliac crest biopsies were obtained in each child. In treatment with 1,25-DHCC episodes of severe but reversible hypercalcemia occurred. Alkaline phosphatase and iPTH normalized completely. Radiographic examinations revealed marked improvement. Histological signs of fibro-osteoclasia and resorptive defects disappeared but there was no recovery of osteomalacia. A reduction of osteoblast population and of bone transformation was obvious. 1,25-DHCC failed to normalize growth in uremic children. In short, neither vitamin D nor 1,25-DHCC can guarantee complete recovery of renal osteodystrophy and growth arrest in uremic children.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    ISSN: 1432-1440
    Keywords: Plasmapheresis ; Hemolytic-uremic syndrome ; Prostacyclin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Three children with hemolytic-uremic syndrome (HUS) were successfully treated with plasmapheresis (PP) combined with early hemodialysis and administration of Aspirin and dipyridamole. Stimulation of vascular prostacyclin release with patients' plasma was measured before and after PP. It was reduced before and increased after plasma exchange. The data indicate that PP might be a useful tool in treatment of (HUS) in children.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 237-247 
    ISSN: 1432-1440
    Keywords: Child ; Renal osteodystrophy ; Vitamin D ; Kind ; renale Osteodystrophie ; Vitamin D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Eine Therapiestudie mit Vitamin D3 in pharmakologischen Dosen bei 27 Kindern in der progredienten Niereninsuffizienz bzw. unter intermittierender Dauerdialysebehandlung über 24 Monate zeigte, daß weder die Vitamin-D3-Behandlung unterstützt durch orale Calciumsupplementation alleine noch in Kombination mit Dialysebehandlung eine renale Osteodystrophie heilen oder verhindern kann. Es gelang zwar in 34,0% der Fälle mit progredienter Niereninsuffizienz und 50% der Fälle unter Hämodialysebehandlung den sekundären Hyperparathyreoidismus für einige Zeit zu suppremieren, eine Suppression auf Dauer konnte allerdings nicht erreicht werden. Das Ausmaß der Mineralisationsstörung und der Wachstumsverzögerung blieb unverändert, die Osteoblastenzahl erlitt mit Suppression des sekundären Hyperparathyreoidismus eine Reduktion, die eine Verminderung des Knochenanbaues und der Knochenmasse unter Dauertherapie mit Vitamin-D3 in pharmakologischen Dosen befürchten läßt. Hypercalcämien und extraossäre Verkalkungen wurden nicht beobachtet.
    Notes: Summary Growth arrest and renal osteodystrophy is a major problem in renal insufficiency of children. The present report describes our experiences in managing renal osteodystrophy by using vitamin D3 for 24 months. Values in plasma of Ca, Mg, alkaline phosphatase, iPTH, 25-OH-D were determined regularly. Skeletal X-rays and analysis of iliac crest bone biopsies were obtained in each child. In treatment with vitamin D3 no hypercalcemia was seen despite high serum levels of 25-OH-D. Plasma-Ca, alkaline phosphatase, and iPTH normalized nearly. Radiographic abnormalities improved. Bone biopsies showed improvement in signs of secondary hyperparathyroidism and ostitis fibrosa, whereas osteomalacia remained unchanged. Osteoblast population showed a small reduction. No real increment in body growth was seen.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 142 (1984), S. 16-20 
    ISSN: 1432-1076
    Keywords: Hemolytic-uremic syndrome ; Antithrombin III ; Hemodialysis ; Plasmapheresis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In nine patients with hemolytic-uremic syndrome, the plasma activity and plasma concentrations of antithrombin III were determined on admission to the hospital and during the clinical course of the disease. Hemodialysis was necessary in six of the patients. In seven children the plasma AT III activity was moderately to markedly below the lower limit of normal at 75%, and did not rise after plasmapheresis with fresh frozen plasma. Replacement therapy with AT III concentrate was started in these patients. During the first 2 days an average dose of AT III concentrate of 2.1 U/kg in 24 h was necessary to raise plasma AT III activity by 1%. No side effects were observed. An already pre-existing procoagulant status and the administration of heparin may lead to AT III deficiency in hemolyticuremic syndrome.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1432-1076
    Keywords: Key words Osteochondrodysplasia ; Cerebral ischaemia ; Immunologic deficiency syndrome ; Kidney failure ; Hypothyroidism ; Focal glomerulosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Schimke immuno-osseous dysplasia (SIOD) is a rare autosomal recessive spondylo-epiphyseal dysplasia. The characteristic features of SIOD include 1) short stature with hyperpigmented macules and an unusual facies, 2) proteinuria with progressive renal failure, 3) lymphopenia with recurrent infections, and 4) cerebral ischaemia. Although 25 patients have been reported with this disorder, the clinical course and phenotype of SIOD are not well characterized. This report summarizes the clinical findings, course and treatment of reported patients and includes 14 additional patients with SIOD. We emphasize the high incidence of cerebral ischaemia and ocular abnormalities, define the high incidence of thyroid dysfunction and blood cytopenia, and confirm the absence of effective and durable medical therapies. Conclusion Schimke immuno-osseous dysplasia is a multi-system autosomal recessive disorder with variable expression that affects the skeletal, renal, immune, vascular, and haematopoietic systems. Medical therapy is limited especially for more severely affected individuals.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Journal of Pharmaceutical and Biomedical Analysis 8 (1990), S. 411-414 
    ISSN: 0731-7085
    Keywords: chronic uraemia ; haemodialysis ; l-Carnitine ; paediatrics ; pharmacokinetics.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    ISSN: 1432-1440
    Keywords: Hyperoxaluria Type I ; Chronic renal failure ; Kidney and liver transplantation ; Childhood
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The difficulties of biochemical diagnosis in children and in chronic renal failure are discussed in detail, as well as the development of diagnostic and therapeutic possibilities in recent years, exemplified by 4 cases. Excretion of oxalate (and glycolate) may be incorrectly assumed to be normal with: a) uncritical application of the method of measurement, b) disregard of the clearly lower oxalate excretion in children (values should be referred to m2 of body surface), c) disregard of a decreased glomerular filtration rate (values should be referred to the creatinine clearance). With compromised renal function the excretion of oxalate and glycolate in primary oxalosis drops to “normal” whereas plasma values increase considerably. In this case the biochemical diagnosis is possible only by measurement of plasma values of glycolate and oxalate. Consequently, extensive extrarenal deposition of calcium oxalate crystals will, as a rule, become clinically manifest only after chronic renal failure has turned irreversible. In recent years, several therapeutic procedures, have been developed. They are of therapeutic significance for the early stages of the disease as well. Observing especially conditions renal transplantation or combined hepatorenal transplantation can be managed with a successful outcome. As the perioxisomal enzyme is activated only in the liver cells, an early liver transplantation as a definitive treatment by enzyme replacement may be the successful therapy in the future.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1432-198X
    Keywords: Key words Rickets ; De Toni-Debré-Fanconi syndrome ; Lactaturia ; Mitochondriopathy ; Cytochrome c oxidase deficiency
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  A 2-year-old boy who developed hypophosphatemic rickets without signs of muscular weakness or neurological disturbances is presented. Biochemical findings included hypophosphatemia, metabolic acidosis, hypouricemia, hyperphosphaturia, severe glucosuria, generalized hyperaminoaciduria, hypercalciuria, proteinuria with elevated excretion of IgG, transferrin, albumin and high levels of α-1-microglobulin. Urine concentration capacity and creatinine clearance were normal. Lactaturia without elevated levels of plasma lactate and a high urinary excretion of β-hydroxybutyrate were suggestive for mitochondriopathy. Partial deficiency of cytochrome c oxidase (complex IV of the respiratory chain) was found in skeletal muscle. A renal biopsy specimen demonstrated enlarged mitochondria with abnormal arborization and disorientation of the cristae in the proximal tubular cells. Reduced activity of mitochondrial cytochrome c oxidase in tubular cells could be demonstrated by ultracytochemistry. In conclusion, rickets due to the renal Fanconi syndrome can be the first clinical sign of mitochondrial cytopathies without extrarenal symptoms. Elevated excretion of lactate and ketone bodies in urine may serve as a diagnostic marker.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    ISSN: 1433-0474
    Keywords: Schlüsselwörter Hämolytisch-urämisches Syndrom (HUS) ; Enterohämorrhagische E. coli (EHEC) ; Verotoxinproduzierende E. coli (VTEC) ; Pankreatitis ; Key words Hemolytic-uremic syndrome (HUS) ; Enterohemorrhagic E. coli (EHEC) ; Verotoxin-producing E. coli (VTEC) ; Pancreatitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Between 1985 and 1993 only 5 children per year were treated for HUS in the Pediatric Nephrology Unit in Münster, whereas 15 (9 girls and 6 boys) were admitted between March to September 1994. 12 of 15 children were 1 to 3 years old. Few days before HUS developed all of them suffered from haemorrhagic diarrhea, two showed CNS-affections, five hypertension, and six suffered from severe pancreatitis. In four families EHEC-food infection was suspected. 2–5 days before diarrhea two children had drank raw milk, one child had consumed undercooked ground beef and another one chicken. We suspect a counection between the increase in verotoxine-producing E. coli especially in cattle (therefore involving the contamination of meat and dairy products) and the increase of HUS. Evidence relating to the patients' histories, their environment, and the incidence of infections in their families supports this hypothesis. In conclusion, to avoid EHEC-transmission, precise records of HUS-infected children must be kept including details of diet, family history and surroundings. Parents should be informed of preventive measures such as boiling unpasteurised milk and thoroughly cooking meat.
    Notes: Zusammenfassung Von März bis September 1994 kam es bei Kleinkindern im Münsterland/Emsland zu einer signifikanten Häufung von HUS-Erkrankungen, bedingt durch enterohämorrhagische E. coli (EHEC). Während wir in der pädiatrischen Nephrologie, Münster, in den Jahren von 1985–1993 durchschnittlich 5 Kinder pro Jahr wegen eines dialysepflichtigen HUS behandelten, waren es 1994 15 Kinder (9 Mädchen, 6 Jungen). 12 der 15 Kinder waren 1–3 Jahre alt. Wenige Tage vor Eintritt des HUS trat bei allen Kindern eine blutige Gastroenteritis als Prodromalerkrankung auf. Neben dem Nierenversagen zeigten 2 Kinder eine ZNS-Manifestation, 5 Kinder entwickelten eine behandlungspflichtige Hypertonie. Bei 6 Kindern fand sich eine schwere Pankreatitis. In 4 Familien bestand der Verdacht auf eine EHEC-Lebensmittelinfektion. 2–5 Tage vor Beginn der Gastroenteritis hatten 2 Kinder Rohmilch getrunken, 1 Kind hatte unzureichend gegartes Rindfleisch verzehrt, 1 weiteres Geflügelfleisch. Wir vermuten, daß eine Ausbreitung der verotoxinbildenden E. coli bei Rindern und eine Kontamination der entsprechenden Nahrungsmittel (unpasteurisierte Milch, rohes Rindfleisch) in direktem Zusammenhang mit der HUS-Häufung steht. Die anamnestischen Hinweise, die Erkrankungen im Familienkreis und die ländliche Umgebung, aus der die Kinder stammen, sprechen für diese These. Wir folgern, daß bei jedem HUS-erkrankten Kind eine genaue Nahrungsmittel-, Familien- und Umgebungsanamnese erhoben werden muß, um Rückschlüsse auf den Infektionsweg zu ziehen und damit weitere Infektionen zu vermeiden. Eltern müssen darüber aufgeklärt werden, daß das Abkochen von Rohmilch und das Durchgaren von Fleischwaren eine Infektion verhindert.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Monatsschrift Kinderheilkunde 148 (2000), S. 142-148 
    ISSN: 1433-0474
    Keywords: Schlüsselwörter ; Harnwegsinfektion ; Asymptomatische Bakteriurie ; Asymptomatische Harnwegsinfektion ; Key words ; Urinary tract infection ; Asymptomatic bacteriuria ; Asymptomatic urinary tract infection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Background: Asymptomatic urinary tract infection is defined as significant bacteriuria and leukocyturia without clinical symptoms of urinary tract infection, without functional disturbance of the urinary bladder and inflammatory signs in blood. Many studies demonstrated that antibiotic treatment is not recommended for children with asymptomatic bacteriuria. Treatment of children with asymptomatic urinary tract infection is discussed controversely. Patients: We report on 2 girls (8 and 10 years old) who had pyelonephritis and vesico- ureteral reflux in early childhood. Primary reflux in one patient was surgically repaired. In the other spontaneous resolution of reflux was observed. At schoolage recurrent asymptomatic bacteriuria and leukocyturia was seen. In patient 1 Proteus mirabilis and E. coli, and in patient 2 Pseudomonas aeruginosa were found in urine. Both children were treated with antibiotics several times. Many recurrences of bacteriuria and leukocyturia were seen. At that time, another voiding cystourethrogram showed no reflux in both children. We stopped antibiotic therapy and 2 years later, urine cultures were negative. Symptomatic urinary tract infections were not observed in the following two years and urine cultures became negative. Ultrasonic examinations of the bladder and kidneys were normal. Conclusions: Antibiotic treatment of children with asymptomatic urinary tract infection (bacteriuria and leukocyturia) is not necessary provided that there are no signs of renal damage, reflux, bladder dysfunction or inflammatory signs in blood. Ultrasonic controls of bladder and kidneys are recommended.
    Notes: Zusammenfassung Hintergrund: Eine asymptomatische Harnwegsinfektion ist charakterisiert durch den Nachweis einer Bakteriurie und Leukozyturie ohne Allgemeinsymptome, ohne Hinweise für funktionelle Blasenkontrollstörungen oder erhöhte Entzündungsparameter im Blut. Zahlreiche Studien haben gezeigt, daß eine asymptomatische Bakteriurie bei morphologisch unauffälligem Harntrakt nicht antibiotisch behandelt werden sollte. Beim Nachweis einer asymptomatischen Harnwegsinfektion wird die Notwendigkeit einer antibiotischen Therapie kontrovers diskutiert. Patienten: Wir berichten über 2 Mädchen (8 und 10 Jahre alt), die im Kleinkindesalter an fieberhaften Harnwegsinfektionen erkrankten und bei denen ein vesikoureteraler Reflux nachgewiesen wurde. Eine Patientin wurde nach Lich-Greogoir operiert, bei dem anderen Mädchen kam es zu einer spontanen Maturation des Refluxes. Bei beiden Kindern wurden im Schulalter rezidivierende Harnwegsinfektionen mit Bakteriurie und ausgeprägter Leukozyturie diagnostiziert, die jedoch symptomlos waren. Während bei Patientin 1 Proteus mirabilis und E. coli im Urin nachgewiesen wurden, war der Harntrakt von Patientin 2 mit Pseudomonas aeruginosa besiedelt. Trotz zahlreicher antibiotischer Behandlungen kam es immer wieder zu Rezidiven. Nach erneutem Ausschluß eines vesikoureteralen Refluxes und unauffälligen Entzündungsparametern im Blut wurde die antibiotische Therapie beendet. Nach 2 Jahren war die Bakteriurie nicht mehr nachweisbar. In diesem Zeitraum waren keine symptomatischen Harnwegsinfektionen beobachtet worden. Ultrasonographische Kontrolluntersuchungen von Blase und Nieren waren unauffällig. Schlußfolgerungen: Die antibiotische Therapie einer asymptomatischen Harnwegsinfektion (Bakteriurie und Leukozyturie) im Schulalter ist nicht erforderlich, wenn Harntransportstörungen, ein vesikoureteraler Reflux, funktionelle Blasenkontrollstörungen und erhöhte Entzündungsparameter im Blut ausgeschlossen sind. Sonographische Kontrollen von Blase und Nieren sind erforderlich.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...