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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 225 (1970), S. 817-820 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Monoamine oxidase exists in at least four molecular forms in different areas of the human brain. Variations in their enzymatic properties may have important clinical implications, perhaps reflecting their relative ability to degrade different monoamine substrates in ...
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 34 (1980), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The effect of tetanus toxin on the uptake and release of radiolabelled transmitters from slices prepared from substantia nigra (SN) and striatum of rats has been investigated. Tetanus toxin-500–750 mouse lethal doses (MLD)-injected into the SN 6 h before preparing the slices significantly reduced the calcium-dependent, potassium-evoked release of [3H]GABA. Endogenous GABA levels in the SN and [3H]GABA uptake by nigral slices were unaffected by pretreatment with the toxin. Injections of tetanus toxin (1000–2000 MLD) into the striatum significantly reduced the calcium-dependent, potassium-evoked release of [14C]GABA and also [3H]dopamine, but had no effect on the K+-evoked release of [3H]5-hydroxytryptamine or [14C]acetylcholine. It is concluded that tetanus toxin inhibits GABA release directly and not by interference with synthesis or inactivation processes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 28 (1977), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 223 (1969), S. 626-628 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It appears3-11 that multiple forms of MAO exist. Solubilized rat and human mitochondrial MAO preparations have been separated electrophoretically into several bands with distinct physico-chemical characteristics57. Although Tipton and Spires12 suggested that pig brain MAO is likely to be a single ...
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 233 (1971), S. 352-354 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 A, Dose-response curves of percentage inhibition of cell firing against coulombs of GABA applied at a constant current of 10 nA. The cell was 1.33 mm deep in the suprasylvian cortex of a cat and was driven by continuous application of 75 nA glutamate. o, Control response; x, response during ...
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Twenty-four 120?150 g female white Wistar rats were divided into four groups of six animals; one group was injected subcutaneously on three consecutive days with 3?3 mg/kg progesterone and another with 3?3 mg/kg oestradiol for a similar period of time. A third received 100, 150, 200 and 300 mg/kg ...
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fig. 1 Distribution of mitochondrial MAO activity (mean ± s.e.) in different anatomical areas of brain from ten untreated (control) subjects. Substrates: 1, kynuramine; 2, tyramine; 3, tryptamine; 4, dopamine. Anatomical areas: CC, cerebral cortex; CB, cerebellum; CO, centrum ovale; BG, ...
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1912
    Keywords: NMDA receptors ; Glycine site agonists and antagonists ; Polysynaptic transmission ; Olfactory cortex
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In this study, it is reported that bath application of D-serine and, to a lesser extent glycine, potentiated polysynaptic but not monosynaptic excitations evoked in slices of mouse olfactory cortex perfused with solution containing Mg2+ (1 mmol/l), picrotoxin and strychnine (both 25 µmol/l). Effects were largely confined to the longer latency components of the field potentials and occurred at amino acid concentrations of between 0.01 and 1 mmol/l. The effects of D-serine and glycine were antagonized by 7-chlorokynurenate and indole-2-carboxylate, antagonists of the glycine regulatory site of the N-methyl-D-aspartate (NMDA) receptor complex. D-Serine (glycine not tested) also potentiated, and 7-chlorokynurenate partially inhibited the longer latency components of the polysynaptic field potentials evoked in slices perfused in the absence of picrotoxin and strychnine. However, neither D-serine nor glycine potentiated responses evoked by the bath application of NMDA. It is concluded that under the present experimental conditions, the glycine regulatory sites of those NMDA receptor involved in the mediation of polysynaptic excitations in the mouse olfactory cortex are not saturated with endogenous glycine.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 341 (1990), S. 114-122 
    ISSN: 1432-1912
    Keywords: Protein kinase C ; Monosynaptic transmission ; Olfactory cortex ; NMDA receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The possible occurrence and role of protein kinase C at the lateral olfactory tract (LOT)-pyramidal cell synapse of the rat olfactory cortex slice has been investigated by determining the effects of both activators (4-β-phorbol-12,13,diacetate [PDAc] and 1,2-dioctanoyl-sn-glycerol) and inhibitors (5-isoquinolinylsulphonyl)-2-methylpiperazine [H-7], sangivamycin and polymyxin B of the enzyme on the surface field potential known as the N-wave. PDAc (0.3 to 20 μmol/l) and 1,2-dioctanoyl-sn-glycerol (25 to 250 μmol/l) increased the area and amplitude of the potential. In control slices in which a population spike was recorded, PDAc also triggered the appearance of multiple spikes. In a series of input-output experiments, PDAc (2.5 or 5 μmol/l) increased the area and amplitude of the N-wave relative to that of the action potential but did not significantly affect pyramidal cell excitability. The effects of PDAc on the N-wave were antagonised by all three protein kinase C inhibitors but not by the calmodulin antagonist calmidazolium and were greater in slices perfused with solution containing 10 rather than 1 mmol/l Mg2+ or 1.25 rather than 5 mmol/l Ca2+. The effect of PDAc on the amplitude but not area of the N-wave was blocked by the potassium channel blocker tetraethylammonium (10 mmol/l) but not by 4-aminopyridine (0.25 mmol/l). In a series of conditioning experiments, PDAc (1 to 5 μmol/l) reduced the amplitude of the N-wave evoked by a second stimulus compared to that evoked by the first conditioning pulse. PDAc also caused a selective, concentration-dependent reduction in the response evoked by Nmethyl-D-aspartate (NMDA), an action blocked by H-7. None of these effects of PDAc was reproduced by 4-\-bphorbol and 4-α-phorbol (10 μmol/l), two analogues of phorbol which do not affect protein kinase C activity. It is concluded that: (i) the effects of PDAc are mediated by activation of protein kinase C; (ii) activation of protein kinase C at the LOT-pyramidal cell synapse potentiates transmission by increasing transmitter release, although an effect of pyramidal cell excitability cannot be ruled out; (iii) protein kinase C may regulate the activity of NMDA receptors.
    Type of Medium: Electronic Resource
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