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  • 1
    ISSN: 1432-0533
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Ce cas est celui d'une enfant qui présentait à la naissance une large masse rétroauriculaire que le diagnostique clinique identifiait comme étant un hémangiome. La radio thérapie eut de très bons résultats. A onze ans on pratiqua l'ablation d'un sarcome cérébelleux qui ne semblait pas avoir été causé par la tumeur rétroauriculaire. Après traitement à moutarde nitrogénée et après trois appliquations de rayon X s'échelonnants pendant neuf mois et demi-soit une dose de radiation d'environ 7,953 r — son état s'aggrava. Pendant quatre traitements de «neutron capture», dirigés principalement sur la région sous-occipitale, on remarqua une amélioration spectaculaire, la malade pouvant s'asseoir et étant même capable de converser pendant quelque temps. Après ce traitement, la tumeur qui s'étendait dans la région sous-occipitale et dans la cou disparut, ainsi que presque toute la tumeur qui se trouvait dans le tiers dorsal du cervelet particulièrement dans la région la plus proche de l'aire sous-occipitale. Dans le tiers moyen cérébelleux on trouva également des agrégats de tumeurs plus ou moins grands, dont quelques-uns calcifiés, qui étaient isolés par un tissu conjonctif hyperplasique. Dans le tiers ventral du cervelet la tumeur ne cessa de croître dans la région non-irradiée par les neutrons. La tumeur était un sarcome d'origine périvasculaire située principalement dans la couche réticulaire cérébelleuse. La vie de la malade fut prolongée d'environ huit mois par le traitement de «neutron capture».
    Notes: Summary This paper deals with a girl who at birth had a large retroauricular mass diagnosed clinically as hemangioma. It responded well to X-ray therapy. When she was 11 years old, a sarcoma was removed from the cerebellum. No evidence could be found that the sarcoma had originated from the retroauricular tumor. After the use of nitrogen mustard locally and after three courses of X-ray therapy to the tumor over a period of 9 1/2 months — a total radiation dose of approximately 7,953 r — the patient was growing moribund. During 4 neutron-capture treatments, which were directed chiefly toward the suboccipital region, striking improvement occurred — to such an extent that the patient was able for a time to sit up in a wheelchair and converse. As a result of the therapy, all tumor which had spread suboccipitally and into the neck vanished, as did also virtually all tumor in the dorsal third of the cerebellum, i.e., in the region receiving the largest concentration of thermal neutrons. In the middle third of the cerebellum large and small tumor aggregates, some of them calcified, were necrotic and were walled off by hyperplastic connective tissue. In the ventral third of the cerebellum, in a region presumably out of the range of an effective concentration of thermal neutrons, the tumor grew unimpeded. Evidence indicated that the sarcoma in our case originated in the vascular sheath, chiefly about vessels in the granular layer of the cerebellum. Life was prolonged approximately 8 months by the neutron-capture therapy.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 20 (1972), S. 78-83 
    ISSN: 1432-0533
    Keywords: Peripheral Nerves ; Bone Marrow ; Glycogen ; Radiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Whole body X-irradiation of rats with 400 rad produced accumulation of glycogen in the nerves of the bone marrow. The glycogen was demonstrated as dense granules 200 to 400 Å in diameter. These granules were present in myelinated, nonmyelinated axons and Schwann cells of the marrow nerves from the first to the thirtieth day after irradiation. About one third of the axons were affected. In normal animals only 5.9% of the nonmyelinated axons showed glycogen, while this substance was not demonstrable in myelinated fibers.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary A procedure is presented for the collection of a large number of hemopoietic stem cells from the peripheral blood of dogs by means of a single leukapheresis using the NCI-IBM Blood Cell Separator. In the course of a leukapheresis of about 285 min duration a mean of 23×109 leukocytes is collected from the blood. The hemopoietic stem cells among such separated leukocytes initiate repopulation of bone marrow within 10 days after whole body X-irradiation with 1200 R. The cell numbers in a defined histological section of femoral bone marrow are evaluated 9 to 10 days after irradiation and subsequent autologous transfusion of 6.72×109 separated mononuclear leukocytes. The results indicate that the bone marrow cell numbers of transfused dogs are significantly greater than in dogs given only 1200 R and reach a level of approximately 49% of the normal value. Possible ways of increasing the yield of hemopoietic stem cells from the peripheral blood will be considered.
    Notes: Zusammenfassung Es wird über ein Verfahren zur Gewinnung großer Zahlen hämopoetischer Stammzellen aus dem peripheren Blut von Hunden durch eine einmalige Leukapherese mit dem NCI-IBM-Blutzellseparator berichtet. Während einer Leukapheresedauer von rund 285 min werden durchschnittlich 23×109 Leukozyten aus dem strömenden Blut abgetrennt. Die unter den abgetrennten Leukozyten befindlichen hämopoetischen Stammzellen sind in der Lage, nach autologer Transfusion in den mit 1200 R ganzkörperbestrahlten Tieren bis zum 10. Tag eine Knochenmarkrepopulation einzuleiten. Die Zelldichte in einem definierten Knochenmarkabschnitt aus dem Femur liegt am 9. bis 10. Tag nach 1200 R und Transfusion einer mittleren Anzahl von 6,72×109 mononukleären Leukozyten signifikant über Vergleichswerten von nur mit 1200 R behandelten Tieren. Die Zelldichte im regenerierenden Knochenmark beträgt an diesen Tagen durchschnittlich 49% der Norm. Möglichkeiten zur Erhöhung der Ausbeute an hämopoetischen Stammzellen des peripheren Blutes werden besprochen.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York, NY [u.a.] : Wiley-Blackwell
    The @Anatomical Record 209 (1984), S. 547-552 
    ISSN: 0003-276X
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The lengths of 491 long bones of the extremities derived from 193 freshly delivered human fetuses of 7 to 22 weeks fertilization age were measured. Fetuses delivered after spontaneous abortion, twin pregnancy, or known maternal disease were excluded. The correlation between fetal age (measured by crown-rump length) and bone length was linear. The term “developmental age” was used for bone length-derived age values. Developmental age can be determined from the length of even a single bone, i.e., when mechanical injury of the delivered fetus inhibits crown-rump length measurement. The results could aid researchers dealing with human embryology, clinicians performing fetal tissue transplantation, and could be applied in forensic medicine as well.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The nerve pattern of the bone marrow of the monkey, rabbit, rat and mouse was studied in serial sections specially stained to demonstrate myelinated and nonmyelinated nerve fibers. Features that are common to the different species studied were found in the bone marrow of the femur of the rat in a simple arrangement.A scheme is proposed based on thirteen photomicrographs demonstrating the nerve pattern of the bone marrow and the relation of the nerve fibers with the arterial tree, the sinusoids and the blood forming cells. This scheme shows that the necessary anatomical conditions exist permitting a direct influence of the nervous system on the function of the bone marrow. These conditions are the presence of myelinated nerve fibers traversing the parenchyma of the marrow, and the existence of nonmyelinated fibers ending in sphincterlike structures at the origin of the arterioles.Single myelinated nerve fibers and small bundles of both myelinated and nonmyelinated fibers lie in close contact with the endothelial wall of the sinuses during long trajects. Only the very thin endothelium of the sinuses separates the newly formed blood and the nerve fibers. An interaction between both elements is possible along these areas of contact.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 0002-9106
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: This study of innervation of the bone marrow in new-born rats demonstrates that major signs of differentiation occur in the nerves at the end of the second week after birth. Myelinated nerve fibers begin to acquire their myelin sheath at this time. The Schwann cells show abundant ergastoplasmic reticulum. Some of these cells separate individual axons and wrap them up with the double membranes that form the myelin sheath. From then on, the nerves of the marrow contain both myelinated and nonmyelinated fibers. Fibroblasts also differentiate during this time, producing collagen fibers around the nerves. Some fibroblasts are interconnected by desmosome-like structures. Fibroblasts and collagen fibers form the connective tissue sheaths of the nerve (perineurium and endoneurium). Upon completion of the myelin sheath by the Schwann cells and the connective tissue sheath by the fibroblasts, nerves of the marrow acquire the morphological characteristics of the peripheral nerves of the adult animal. The fine structure of the axons in contact with the muscle fibers of the arterial wall correspond to Type 2-a of Watari. These nerve fibers are considered to be of sympathetic type. The time of maturation of nerves in the bone marrow coincides with the beginning of responsiveness to stimulatory and inhibitory conditions demonstrated in this organ by other authors.
    Type of Medium: Electronic Resource
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