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  • 1
    ISSN: 1432-0738
    Keywords: Isoenzymes ; Acetylcholinesterases ; Foetus ; Insecticidal carbamate ; Carbaryl ; Aldicarb ; Carbofuran ; Pirimicarb
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Pregnant rats (18th day) were orally given insecticidal carbamates with anticholinesterasic properties: 50 mg/kg carbaryl, 0.1 mg/kg aldicarb, 2.5. mg/kg carbofuran and 20 mg/kg pirimicarb. The acetylcholinesterase (AChE) isoenzymes from the brain of mothers and their foetuses were separated by electrophoresis on polyacrylamide gel. The four carbamate derivatives caused a significant lowering of the percentage of the least mobile isoenzyme (isoenzyme 1) in mother. Aldicarb, carbaryl and pirimicarb also caused a significant decrease in the percentage of the first foetal isoenzyme. The second foetal isoenzyme underwent a decrease after treatment with aldicarb or carbofuran. The distribution of the foetal isoenzymes was seen to be different to that of the dams in both control and treated animals. The difference in sensitivity of the cerebral AChE to the insecticides under investigation is thought to depend on differences of the fixation of carbamate derivatives on the foetal and maternal isoenzymes.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism 1167 (1993), S. 165-174 
    ISSN: 0005-2760
    Keywords: (Rat) ; Allergen challenge ; Icosanoid ; Membrane phospholipid ; Passive sensitization ; Peritoneal macrophage
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 105 (1996), S. 2813-2815 
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: For an electrochemical system with a nonvanishing relaxation time we obtain a generalized Warburg impedance from a hyperbolic diffusion equation. The generalized Warburg impedance determined in this way presents a slight positive curvature in the complex plane with smaller imaginary value at high frequencies. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Physics of Fluids 6 (1994), S. 2084-2100 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: This paper investigates some irreversible mechanisms occurring in homogeneous stably stratified turbulent flows. In terms of the eigenmodes of the linear regime, the velocity-temperature field is decomposed into a vortex and two wavy components. Using an eddy-damped quasinormal Markovian (EDQNM) closure with the axisymmetry hypothesis, an analysis of the anisotropic energy transfers between the vortex kinetic energy, the wave kinetic and potential energy is made. Within the light of triadic exchanges, and by analogy of the resonance condition for three linearly interacting gravity waves, the closure model allows one to compute the detailed transfers for eight types of interactions. Results of the calculations include time evolution plots, for the isotropic closure model as well as two different types of the anisotropic closure. The pure vortical interactions are shown to be responsible for the irreversible anisotropic structure created by stable stratification, and this structure prevents the inverse cascade of two-dimensional turbulence.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 5 (1993), S. 2539-2550 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Amplification of turbulent kinetic energy in an axial compression is examined in the frame of homogeneous rapid distortion theory (RDT) by using the Craya–Herring formalism. By separating the turbulent field into solenoidal and dilatational modes (Helmholtz decomposition), one can show the dilatational mode is mediated by the parameter Δm0=D0/a0k0, which corresponds to the initial ratio between the acoustic time scale (a0k0)−1 and the compression time scale D0−1, with D0 the compression rate. It is shown here that amplification of total kinetic energy is then limited by two analytical solutions obtained for Δm0=0 (purely solenoidal-acoustical regime) and for Δm0(very-much-greater-than)1 ("pressure released'' regime), respectively. The results of the theory are first compared to results of direct numerical simulations (DNS) on homogeneous axial compression. The applicability of this homogeneous approach to the shock wave turbulence interaction, is then discussed. Considering a shock-induced compression at given Mach number, it is shown that the corresponding amplification factors predicted by homogeneous RDT largely differs from that obtained from Ribner's linear interaction analysis and DNS on the shock problem.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    New York, NY : American Institute of Physics (AIP)
    Physics of Fluids 4 (1992), S. 812-824 
    ISSN: 1089-7666
    Source: AIP Digital Archive
    Topics: Physics
    Notes: A new approach for modeling turbulent rotating flows is presented. The main objective of this model is to take into account the complex effects of background rotation, which have been elucidated by homogeneous spectral analysis. The model is based on the following elements. First, it is shown, or recalled, that the use of the deviatoric part aij=Rij/Rll−δij/3 of the Reynolds stress tensor Rij as the unique tensorial argument for closing unknown terms (a basic principle in actual models) is no longer valid in the presence of solid body rotation. A decomposition of this tensor into two parts (aij=aeij+aZij), namely aeij (directional dependence) and aZij (polarization), is suggested from pure inviscid and homogeneous rapid distortion theory.It is shown that the first part aeij is preserved while the second aZij is damped by the pressure-velocity correlations through the action of the Coriolis force. This decomposition appears to provide the minimum amount of information in physical space needed to deal with the complexity of the problem. A system of equations for aeij and aZij is then given for predicting in an "ad hoc'' way some phenomena consistent with those identified by spectral models, recent direct numerical simulations (DNS), and experimental results. These phenomena are: (1) damping of any term attached to nonlinear interactions at very low Rossby numbers, in accordance with a convenient modification (for rotation) in the ε (dissipation rate) equation, (2) linear "rapid'' reorganization of an initial anisotropy, as shown by pure inviscid rapid distortion theory, and (3) nonlinear "Taylor–Proudman structuring'' at intermediate Rossby numbers. Although the present model is restricted to the case of pure solid body rotation, developments that could lead to a more general version that takes into account any kind of mean velocity gradient are discussed at the end of the paper. For this purpose, a consistent closure is provided for the "rapid'' pressure rate of the strain correlation tensor Φ2ij=eΦ2ij+ZΦ2ij (involved in the Rij equation), and for the related contribution involved in the equation for Reij=Rllaeij, without introducing any adjustable constant. Finally, we present a general two-tensor model (Rij,Reij;ε) of which we hope will encourage new efforts in second-order modeling.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Fluid Dynamics Research 13 (1994), S. 281-298 
    ISSN: 0169-5983
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 359 (1999), S. 428-431 
    ISSN: 1432-1912
    Keywords: Key words Monoamine oxidases ; Hydrogen peroxide ; Chemiluminescence ; Hep-G2 cells ; Renal proximal ; tubule cells ; Mesangial cells ; Tyramine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Monoamine oxidase (MAO) A and B are mitochondrial enzymes involved in the oxidative deamination of endogenous and exogenous amines. At present, the production of H2O2 by MAO in intact cells and its functional consequences in cell function have not been extensively investigated. The aim of this study was to define whether, in intact cells, the metabolism of small amounts of MAO substrates was able to induce a detectable H2O2 production. Hydrogen peroxide production was measured using a luminol-amplified chemiluminescence assay in three cell types, rat mesangial cells, rabbit proximal tubule cells and Hep-G2 cells, containing different MAO A/MAO B ratios. Our results showed that cell incubation with tyramine (50 μmol/l) led to a time-dependent H2O2 generation which was fully inhibited by MAO A (clorgyline and RO 41–1049) and MAO B (selegiline and RO 19–6327) inhibitors. The extent of inhibition of H2O2 production by selective inhibitors was in agreement with the amount of MAO isoforms expressed in each cell type, as determined by Western blot analysis and enzyme assay. Altogether, these findings show that, in a normal cell environment, MAO can be a source of reactive oxygen species which could have a functional impact on cell functions. In addition, we propose the luminol-amplified chemiluminescence assay as a rapid and sensitive procedure to characterize the monoamine oxidase isoforms and their regulation in intact cells.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Flow, turbulence and combustion 51 (1993), S. 197-202 
    ISSN: 1573-1987
    Keywords: homogeneous turbulence ; elliptical flow ; spectral approach ; linear analysis ; two-point closure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract A new configuration of distorted homogeneous turbulence is investigated in the domain of rotation-dominated elliptical flows. The experimental results are compared with “exact” numerical solutions obtained in Fourier space for the linear part of the problem. The inherently periodic character of the flow results in typical oscillatory variations of the anisotropy and the pressure-strain correlations. A new two-point closure approach of the EDQNM type is proposed for the nonlinear problem; it is based on a representation of the spectral tensor by scalar functions expanded in terms of spherical harmonics.
    Type of Medium: Electronic Resource
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