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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 167 (1969), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 18 (1973), S. 384-390 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Three patients with giardiasis have been shown to have vitamin B12 malabsorption which returned to normal after eradication of the parasite. Radioactive vitamin B12 with sufficient amounts of biologically active intrinsic factor to exclude host intrinsic factor deficiency was administered. The subjects did not suffer from immunodeficiency states, and bacterial overgrowth did not appear to be a causative factor. The implications of this finding in relation to mechanisms of malabsorption in giardiasis are discussed. It is concluded that competition between parasite and host enterocyte is the most likely explanation for vitamin B12 malabsorption.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Digestive diseases and sciences 22 (1977), S. 255-262 
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A ten-year-old boy presented with a prolonged cholestatic liver disease 5 weeks after starting diphenylhydantoin therapy. The initial phase of his illness was characterized by hepatocellular damage with swollen liver cells and centrilobular cholestasis. Severe hyperlipoproteinemia with eruptive xanthomata developed within 3 weeks of his initial jaundice. The second phase of his illness was characterized by portal tract inflammation with bile ductular proliferation and chronic cholestasis gradually resolving over a period of 15 months. It is postulated that diphenylhydantoin sensitivity produced swollen hepatocytes with hypertrophy of the smooth endoplasmic reticulum, reducing hepatic sinusoidal blood flow and the clearance of secondary bile salts. A fall in clearance of lipoproteins, including the cholesterol precursor of primary bile acid synthesis, may have been responsible for a reduction in serum bile acid concentration. High levels of serum lithocholic acid, largely unsulfated presumably due to decreased hepatic uptake, may have produced the prolonged second phase of this illness when histological changes resembled that seen in experimental animals following lithocholic acid administration.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1573-2568
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A sensitive gas-liquid chromatographic assay has been used to analyze serum concentrations of the four major bile acids in both sulfated and nonsulfated forms. Twelve control subjects have been compared with 40 patients with acute viral hepatitis whose symptoms had been present from 6 to 34 days. In all subjects blood samples were collected fasting and 2 hr after a standard meal. In addition half-hourly samples were assayed for 3 hr after the meal in 6 controls and 5 patients with acute viral hepatitis. In both the control and hepatitis groups, serum concentrations of nonsulfated bile acids, especially cholic and chenodeoxycholic acids, increased after the meal. The peak levls usually occurred between 60 and 120 min in the half-hourly studies. In contrast, sulfated bile acids fell in both groups with minimum levels 60–120 min after the meal. Serum total bilirubin, aspartate aminotransferase, and alkaline phosphatase concentrations in hepatitis patients correlated significantly with postprandialitotal bile acid concentrations but were more frequently abnormal than serum total or individual bile acids. Unconjugated bile acids were not detected in control subjects but were found in 17 of the 40 hepatitis patients. Significantly higher levels of sulfated bile acids and chenodeoxycholic acid were present in hepatitis patients compared to controls. In this group of patients with acute viral hepatitis, studied soon after presentation to hospital but in some cases, some time after the onset of their disease, measurement of serum bile salts was not helpful as an index of hepatocellular function. Postprandial variation in the time of peak concentrations of the individual bile acids resulted in the postprandial bile acid studies being no more useful than fasting assays in distinguishing patients with acute viral hepatitis from control subjects.
    Type of Medium: Electronic Resource
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