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  • 1
    Electronic Resource
    Electronic Resource
    Antioxidant Activity and Protective Effect on DNA Cleavage of Resveratrol (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 67 (2002), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : The major natural polyphenols of wine are flavonoids. Red wine also contains a natural phytoalexin called resveratrol which recently has been the subject of conflicting reports regarding its protective role against cardiovascular diseases. We have investigated the free radical scavenging capacity of resveratrol, its effects on xanthine oxidase (XO) activity, spontaneous membrane lipid oxidation, and DNA cleavage. Resveratrol showed a dose-dependent free radical scavenging activity, significant inhibition of XO activity, an anti-lipoperoxidative capacity, and a protective effect on DNA cleavage. The antioxidant capacity of resveratrol is ascribed to the concomitant activities of scavenging free radicals, metal chelating, and inhibition of some enzymes involved in free radical generation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2002.tb11373.x
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  • 2
    Electronic Resource
    Electronic Resource
    Red Orange Extract: Effect on DNA Cleavage (2002)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 67 (2002), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: : Red oranges are characterized by high levels of anthocyanins, with a high content of other antioxidant compounds such as flavones, hydroxycinnamic acids, and ascorbic acid. In this work, we investigated effects of standardized extract from red oranges on DNA cleavage and its free radical scavenging capacity. In addition, its effect on xanthine oxidase activity and lipid oxidation in rat-liver microsomes was evaluated. The extract showed a protective effect on DNA cleavage and a dose-dependent free radical scavenging capacity. These results were confirmed by significant inhibition of xanthine oxidase activity and an antilipoperoxidative capacity. The evidence suggests that, because of its antioxidant activity, the extract may offer excellent photoprotection for skin and may be useful in treatment of diseases where oxidative stress plays a role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.2002.tb08821.x
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  • 3
    Electronic Resource
    Electronic Resource
    Lipid peroxidation and antioxidant enzymatic systems in rat retina as a function of age
    Amsterdam : Elsevier
    Free Radical Biology and Medicine 9 (1990), S. 125 
    Details
    ISSN: 0891-5849
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0891-5849(90)90622-P
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  • 4
    Electronic Resource
    Electronic Resource
    HO-1 expression in primary cultured astroglial cells (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Heme oxygenase (HO)-1 catalyzes the rate-limiting step in heme degradation. The aim of the study was to determine HO-1 expression and distribution pattern in glial cells during differentiation and after exposure to glutamate (GLU) (100 μm). In untreated cells at 7 days in vitro (DIV) HO-1 expression was undetectable whereas increased at 14 and 21 DIV. Exposure to GLU for 24 h at 7, 14 and 21 DIV increased the expression of HO-1; this effect was prevented by preincubation with GYKI 52466. In untreated cells at 7 DIV, HO-1 fluorescence was weak; the protein appeared in the cytosol and the fluorescence intensity increased at 14 and 21 DIV. Compared with untreated cells, the addition of GLU increased the fluorescence and the enzyme translocated in the nucleus and nucleoli. These results demonstrate the presence of HO-1 in the glial cells and the translocation in the nuclear compartment of astrocytes during differentiation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.85.s2.22_8.x
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  • 5
    Electronic Resource
    Electronic Resource
    Transglutaminase increases during astrocyte differentiation by interplay of growth factors and steroids (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 85 (2003), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Development of primary cultured astrocytes can be influenced by interplay of steroids and growth factors (GFs). These mytogenic polypetides regulated the expression of cytoskeletal proteins depending on pretreatment with either dexamethasone (DEX) or estradiol (E2). We evaluated the contribution of each of these treatments to the expression of tissue transglutaminase (tTG), that is involved in cell differentiation. Treatment for 12 h with E2 and EGF as well as DEX and IGF-I significantly increased tTG expression in 15 DIV astrocyte cultures. A proliferative marker, such as cyclinD1 decreased as consequence of treatment increasing tTG expression. Taken together, these results indicate that steroid-GFs cross-talk plays a crucial role during astroglial cell maturation, and tTG may be indicated as mediator of the proliferative/differentiative response of primary cultured astrocytes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.85.s2.22_7.x
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  • 6
    Electronic Resource
    Electronic Resource
    Kinetics and equilibria of Ga(III)thiocyanate complex formation. Mechanism of ligand substitution reactions of Ga(III) in aqueous solution
    Amsterdam : Elsevier
    Inorganica Chimica Acta 100 (1985), S. 251-259 
    Details
    ISSN: 0020-1693
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0020-1693(00)85294-9
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of acetyl-l-carnitine on lipid peroxidation and xanthine oxidase activity in rat skeletal muscle (1993)
    Springer
    Neurochemical research 18 (1993), S. 1157-1162 
    Details
    ISSN: 1573-6903
    Keywords: Lipoperoxidation ; acetyl-l-carnitine ; xanthine oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract It has been reported that acetyl-l-carnitine (AcCn) can reduce the degenerative processes in the central nervous system of rats, modify the fluidity of membranes and decrease the accumulation of lipofuscins in neurones. In light of these considerations we have assayed the in vitro effect of acetyl-l-carnitine on spontaneous and induced lipoperoxidation in rat skeletal muscle; in addition, the effect of AcCn on XD/XO ratio was evaluated. The presence of AcCn (10–40 mM) in incubation medium significantly reduced MDA and conjugated diene formation in rat skeletal muscle; moreover, a significant decrease in induced MDA levels was observed when microsomal preparation where incubated in the presence of 10–40 mM AcCn. Since a significant reduction of XO activity was detected in the presence of 10–80 mM AcCn, the reduced lipid peroxidation by AcCn seems to be due to an inhibition of XO activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00978367
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  • 8
    Electronic Resource
    Electronic Resource
    Free radical scavenger depletion in post-ischemic reperfusion brain damage (1993)
    Springer
    Neurochemical research 18 (1993), S. 1337-1340 
    Details
    ISSN: 1573-6903
    Keywords: Ischemia ; reperfusion ; scavenger ; GSH-depletors ; survival
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In the present study the influence of pretreatment with various GSH depletors such as buthionine sulfoximine (BSO) and diethylmaleate (DEM) was investigated in rats following cerebral postischemic reperfusion. Moreover, the effect of diethyldithiocarbamic acid (DDC), inhibitor of endogenous Cu,Zn-SOD, was evaluated. A significant depletion (40% of control value) of GSH levels was observed 24 h after DEM administration; after 48 h the value reached control levels. BSO showed maximal GSH depletion (59%) 24 h after administration and it was constant for almost 48 h. DDC administration caused a marked decrease (60%) of Cu,Zn-SOD activity 4 h after the injection and induced a marked decrease in percentage of survival with respect to control (untreated, ischemic) rats, when administered 4 h before ischemia. BSO and DEM prolonged the survival time of animals when administered 24 h before ischemia. This last paradoxical effect is unclear at present, but it might be due to an influence on glutamate cascade.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00975056
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  • 9
    Electronic Resource
    Electronic Resource
    Ornithine Decarboxylase Activity in Cerebral Post-Ischemic Reperfusion Damage: Effect of Methionine Sulfoximine (1997)
    Springer
    Neurochemical research 22 (1997), S. 1145-1150 
    Details
    ISSN: 1573-6903
    Keywords: Cerebral ischemia ; reperfusion ; survival ; polyamines ; ODC ; GS
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Excessive activation of glutamate receptors via the N-methyl-D-aspartate (NMDA) subtype appears to play a role in the sequence of cellular events which lead to irreversible ischemic damage to neurons. Furthermore, NMDA receptor activation induces a stimulation of ornithine decarboxylase (ODC), the rate-limiting enzyme for polyamine (PA) biosynthesis. In order to better understand the role of PA we have measured ODC activity and the effect of methionine sulfoximine (MSO), a molecule able to stimulate ODC, on a model of transient cerebral ischemia. There was a significant increase in ODC activity in the rat cerebral cortex during post-ischemic reperfusion. The treatment with MSO induced a significant decrease in cerebral glutamine synthetase activity accompained by a marked increase in ODC activity. In MSO-pretreated rats there was a significant decrease in the survival rate when compared to untreated ischemic rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1027321420075
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  • 10
    Electronic Resource
    Electronic Resource
    Transglutaminase activity in primary and subcultured rat astroglial cells (1992)
    Springer
    Neurochemical research 17 (1992), S. 1201-1205 
    Details
    ISSN: 1573-6903
    Keywords: TGase ; glial cells ; cell passages ; differentiation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Transglutaminases, calcium-dependent thiol enzymes, may be involved in cellular growth control and differentiation, having an intracellular regulatory role in some post-traslational modifications found in various classes of proteins. In order to elucidate the involvement of this class of enzymes in cellular differentiation processes, we have assayed transglutaminase activity in primary and subcultured rat glial cells. Reduced activity was found from 3rd to 5th passage. In the 5th passage the activity was some 50% of that found in the primary cultures and was not restored by addition of 10 μM retinoic acid. The decrease of TGase activity, observed during serial passages, could represent an early metabolic alteration related to cell dedifferentiation and loss of growth control. In fact, the subcultured cells may have undergone a “disarranged” state, as confirmed by a decrease in GFAP-stained cells and glutamine synthetase activity, respectively, immunocytochemical and biochemical markers of astroglial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00968400
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