ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Byproducts of peptide synthesis, formed in the course of accidental attack by Pd-activated oxygen on ethanol and triethylamine in reaction media, have been identified as products of condensation between peptides and acetaldehyde, and demonstrated to represent N,N′-alkylidenepeptides, i.e. derivatives of 4-imidazolidinones. The same products are obtained by direct action of acetaldehyde on the respective peptides, and analogs resulted in some cases when acetaldehyde was replaced by formaldehyde or acetone. The condensation is reversible, imidazolidinone stability depending on structural features of both the involved peptide and carbonyl compound. There are evidently implications of these findings with respect to the chemistry and biochemistry of peptides and proteins.
Additional Material:
1 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19730560125
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