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  • 1
    Electronic Resource
    Electronic Resource
    P22 Arc Repressor: Transition State Properties Inferred from Mutational Effects on the Rates of Protein Unfolding and Refolding (1995)
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 13914-13919 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00042a024
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Domains of Mnt Repressor: Roles in Tetramer Formation, Protein Stability, and Operator DNA Binding (1995)
    s.l. : American Chemical Society
    Biochemistry 34 (1995), S. 13109-13116 
    Details
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/bi00040a023
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Vestibular nucleus projections to nucleus tractus solitarius and the dorsal motor nucleus of the vagus nerve: potential substrates for vestibulo-autonomic interactions (1994)
    Springer
    Experimental brain research 98 (1994), S. 200-212 
    Details
    ISSN: 1432-1106
    Keywords: Vestibular nuclei ; Autonomic nervous system ; Nucleus tractus solitarius ; Dorsal motor vagal nucleus ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Autonomic effects of vestibular stimulation are important components of phenomena as diverse as acute vestibular dysfunction and motion sickness. How ever, the organization of neural circuits mediating these responses is poorly understood. This study presents evidence for direct vestibular nucleus projections to brain stem regions that mediate autonomic function. One group of albino rabbits received injections of Phaseolus vulgaris leucoagglutinin into the vestibular nuclei. The tracer was visualized immunocytochemically with standard techniques. Anterogradely labeled axons from the caudal medial vestibular nucleus (cMVN) and inferior vestibular nucleus (IVN) could be traced bilaterally to nucleus tractus solitarius (NTS). Fewer axons ended near the somata of neurons in the dorsal motor nucleus of the vagus nerve (DMX). A second group of rabbits received pressure or iontophoretic injections of cholera toxin B-HRP or Fluoro-Gold into a region including NTS and DMX. Retrogradely labeled neurons were observed bilaterally in the caudal half of cMVN and ipsilaterally in IVN. The labeled somata were small and they tended to occupy the center of cMVN in transverse sections. These previously unreported vestibular nucleus projections to NTS and DMX are a potential substrate for vestibular influences on autonomic function. In particular, they may contribute to both cardiovascular control during head movements (e.g., orthostatic reflexes) and autonomic manifestions of vestibular dysfunction, motion sickness and exposure to altered gravitational environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00228409
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    A “beat-to-beat” interval generator for optokinetic nystagmus (1992)
    Springer
    Biological cybernetics 66 (1992), S. 203-216 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract An analysis of optokinetic responses was used to derive an iterative model that reproduces the duration of nystagmus slow phases and eye position control during optokinetic nystagmus. Optokinetic nystagmus was recorded with magnetic search coils from red-eared turtles (Pseudemys scripta elegans) during monocular, random dot pattern stimulation at constant velocities ranging from 0.25–63%. The beat-to-beat behavior of slow phase durations was consistent with the existence of an underlying neural clock, termed the basic interval generator, that is based on an integrate-to-fire neuron model. This hypothetical basic interval generator produces an interval that is the product of the duration of the previous interval and a mean 1 truncated normal variate with variance σ2. Data analyses indicated that the initial value of the interval generator during a period of nystamus, termed τ0, is proportional to the inverse square root of slow phase eye velocity. Further, if the eye was deviated in the slow phase direction (re mean eye position) when the slow phase began, the slow phase duration was consistent with a single cycle of the basic interval generator. However, if the eye was deviated in the fast phase direction, the distribution of the durations of the ensuing slow phases indicated that a proportion of the slow phases were produced by more than one cycle of the basic interval generator. This phenomenon is termed “skipping a beat” and occurs with probability p s . Finally, the amplitude of fast phases behaved as a linear function of eye position at the fast phase onset and the product of τ0 and slow phase eye velocity. A computer simulation reproduced the observed distribution of slow phase durations, the proportion of fast phases in the fast phase and slow phase directions and the distribution of eye positions at the onset and end of fast phases. This novel model suggests that both timing and eye position information contribute to the alternation of nystagmus fast and slow phases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00198474
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  • 5
    Electronic Resource
    Electronic Resource
    The perception and prehension of objects oriented in the depth plane (1996)
    Springer
    Experimental brain research 112 (1996), S. 442-451 
    Details
    ISSN: 1432-1106
    Keywords: Visual agnosia ; Visuomotor control ; Orientation ; Depth ; Binocular vision
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Previous studies have reported that the visual form agnosic D.F. is able to use information about visual targets for the control of motor acts, but has great difficulty in using the same visual information for perceptual report. This intact visuomotor performance may be mediated by relatively intact parieto-frontal cortical mechanisms. The present study investigated the ability of D.F. to use binocular and monocular information about the orientation of an object in the depth plane for perceptual and visuomotor purposes. A square plaque was presented at seven different orientations in depth to D.F. and to three age- and sex-matched control subjects. Subjects were required to reach out and grasp the plaque using a precision grip (index finger and thumb) under binocular and monocular viewing conditions, and in separate trials to match the orientation of a hand-held plaque to the perceived orientation of the target object, also under both binocular and monocular conditions. D.F.'s performance in grasping trials was found to be normal under binocular conditions, but was substantially worsened by removal of binocular vision. She was severely impaired at matching the orientation of the test square, although under binocular conditions her performance rose clearly above chance. The data suggest that the separation of cortical processing for visuomotor and visual perceptual purposes also applies, at least in part, to information about the orientation in depth of an object. The impaired performance under monocular viewing conditions on the visuomotor task is in agreement with recent physiological data and suggests that posterior parietal systems depend critically on binocular input for the processing of orientation in depth when ventral-stream information is unavailable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227950
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  • 6
    Electronic Resource
    Electronic Resource
    Vestibular nucleus projections to the parabrachial nucleus in rabbits: implications for vestibular influences on the autonomic nervous system (1996)
    Springer
    Experimental brain research 108 (1996), S. 367-381 
    Details
    ISSN: 1432-1106
    Keywords: Vestibular nuclei ; Autonomic nervous system ; Parabrachial nucleus ; Rabbit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Acute vestibular dysfunction and motion sickness are characterized by autonomic effects such as pallor, nausea, and vomiting. Previous anatomic and physiologic studies suggest that one potential mediator of these effects may be light, direct vestibular nuclear projections to the nucleus tractus solitarius and the dorsal motor nucleus of the vagus nerve. This study presents evidence for relatively dense, direct projections from the vestibular nuclei to the parabrachial nucleus. Male albino rabbits received injections of Phaseolus vulgaris leucoagglutinin into the vestibular nuclei. The tracer was visualized immunocytochemically with standard techniques. Anterogradely labeled axons were traced bilaterally from the vestibular nuclei to the parabrachial nuclear complex, where they terminated around somata in the Kölliker-Fuse nucleus, external medial parabrachial nucleus, medial parabrachial nucleus, and lateral parabrachial nucleus. Less dense terminations were observed in the ventrolateral aspect of the medullary reticular formation, the subtrigeminal nucleus, lateral tegmental field, and nucleus ambiguus. These findings have several important implications. First, they suggest that vestibular input converges directly at brain stem levels with visceral sensory input in both nucleus of the solitary tract and the parabrachial complex. Second, they suggest that vestibular input influences brain stem autonomic outflow via two parallel pathways: (1) direct, light projections to the nucleus of the solitary tract, dorsal motor nucleus of the vagus nerve, and ventrolateral medullary reticular formation; and (2) denser projection to regions of the parabrachial nucleus that project to these brain stem regions. Finally, since the parabrachial nucleus regions that receive vestibular input also project to the hypothalamus and the insular and infralimbic prefrontal cortex, the parabrachial nucleus may serve as an important relay and integrative structure for the cognitive impairment and vegetative symptoms associated with motion sickness, vestibular dysfunction, and responses to altered gravitational environments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00227260
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  • 7
    Electronic Resource
    Electronic Resource
    THE STABILITY OF ASCORBIC ACID IN FROZEN AND BOTTLED ACEROLA JUICE ALONE AND COMBINED WITH OTHER FRUIT JUICES (1960)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 25 (1960), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1960.tb00324.x
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  • 8
    Electronic Resource
    Electronic Resource
    The Sodium Content of Hawaii-Grown Fruits and Vegetables in Relation to Environment (1961)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 26 (1961), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Notes: From four of the major islands in the Hawaiian chain, 19 foods of plant origin, the soil in which they were grown and the water used for irrigation were assayed for sodium. Data on the influence of environment upon the sodium content of fruits and vegetables are given. Most fruits and vegetables were low in sodium. A few, such as papaya, beets, celery, daikon, and sweetpotato, were high and probably should be omitted from very restricted sodium diets. The sodium concentration of some of the foods varied with the soil sodium concentration, which points out the necessity of considering the source of these particular foods before using them in a sodium-restricted diet. The results indicate that variations in sodium should be expected in plant foods, although the differences may not always be nutritionally significant.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1961.tb00036.x
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  • 9
    Electronic Resource
    Electronic Resource
    Cytotoxic Effects of Somatostatin in the Cerebellum (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 656 (1992), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1992.tb25259.x
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  • 10
    Electronic Resource
    Electronic Resource
    PEANUT BUTTER AS A SOURCE OP THIAMIN, CALCIUM, PHOSPHORUS, AND IRON (1943)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 8 (1943), S. 0 
    Details
    ISSN: 1750-3841
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2621.1943.tb16540.x
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