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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 117 (1995), S. 3871-3872 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Langmuir 7 (1991), S. 2492-2497 
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Conclusion Cette étude a montré la communication possible des liquides entre les régions paravertébrales thoracique et lombaire à travers le fascia endothoracique. Les observations de Lönnqvist à propos de la limite caudale de l'anesthésie paravertébrale thoracique semble pouvoir être remises en cause bien que n'ayons pas examiné de cadavre d'enfant [11]. Il y a des malentendus en ce qui concerne la diffusion du liquide dans le fascia endothoracique. Leur correction est importante pour l'application clinique ultérieure de l'anesthésie paravertébrale.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1279-8517
    Keywords: Lumbar plexus ; Intercostal nerves ; Anesthesia regional ; Paravertebral block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Summary An injection of a local anesthetics in the paravertebral region produces an analgesic field on the same side of the body, a paravertebral block. One point in question about this block is whether the local anesthetic spreads from the thoracic to the lumbar level of the paravertebral region. The purpose of this study was to find how the anesthetic fluid traveled to the lumbar paravertebral region, if at all. Twelve cadavers were used in this study. 15 ml of crimson dye was injected into the paravertebral region at the 11th thoracic level. The viscerae were removed so that we could examine the dye spread. While the crimson dye spread in the endothoracic fascia posterior to the parietal pleura, it also spread downward in the fascia mostly along the splanchnic nerves. At the upper surface of the diaphragm the dye spread laterally in the fascia, and entered the abdominal cavity through the medial and lateral arcuate ligaments. In the abdominal cavity, the dye was found to have spread so widely in the transversalis fascia that the subcostal, iliohypogastric, ilioinguinal, genitofemoral, lateral femoral cutaneous and femoral nerves were involved. We concluded that the dye in the thoracic paravertebral region can enter the abdominal cavity through the medial and lateral arcuate ligaments. This study explained possible fluid communication between the thoracic and lumbar paravertebral regions and confirmed our former clinical observations. The result is important for the future clinical application of paravertebral anesthesia.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1279-8517
    Keywords: Lumbar plexus ; Intercostal nerves ; Anesthesia regional ; Paravertebral block
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'injection d'un anesthésique local dans la région paravertébrales entraîne une analgésie unilatérale localisée (bloc paravertébral). On pouvait se demander si l'anesthésique local diffusait du niveau thoracique au niveau lombaire de la région paravertébrale. Le but de cette étude était de définir comment le liquide anesthésique gagnait la région paravertébrale lombaire, s'il le faisait. 12 cadavres ont été utilisés dans cette étude. 15 mm de colorant rouge ont été injectés dans la région paravertébrale des cadavres au niveau de la 11ème vertèbre thoracique. Les viscères ont ensuite été enlevés pour permettre l'examen de la diffusion du colorant. Le colorant diffusait dans le fascia endothoracique en arrière de la plèvre pariétale, puis vers le bas à l'intérieur du fascia, principalement le long des nerfs splanchniques. A la face supérieure du diaphragme, il diffusait latéralement dans le fascia, et pénétrait dans la cavité abdominale au-dessous des ligaments arqués médial et latéral. Dans la cavité abdominale, le colorant diffusait largement dans le fascia transversalis de telle sorte qu'il atteignait les nerfs subcostal, ilio-hypogastrique, ilio-inguinal, génito-fémoral, cutané latéral de la cuisse, et fémoral. Nous en avons conclu que le colorant pouvait passer de la région paravertébrale thoracique dans la cavité abdominale au-dessous des ligaments arqués médial et latéral. Cette étude montre la communication possible des liquides entre les régions paravertébrales thoracique et lombaire, et corrobore nos observations cliniques préalables. Le résultat en est important pour l'utilisation clinique ultérieure des blocs paravertébraux.
    Notes: Summary An injection of a local anesthetics in the paravertebral region produces an analgesic field on the same side of the body, a paravertebral block. One point in question about this block is whether the local anesthetic spreads from the thoracic to the lumbar level of the paravertebral region. The purpose of this study was to find how the anesthetic fluid traveled to the lumbar paravertebral region, if at all. Twelve cadavers were used in this study. 15 ml of crimson dye was injected into the paravertebral region at the 11th thoracic level. The viscerae were removed so that we could examine the dye spread. While the crimson dye spread in the endothoracic fascia posterior to the parietal pleura, it also spread downward in the fascia mostly along the splanchnic nerves. At the upper surface of the diaphragm the dye spread laterally in the fascia, and entered the abdominal cavity through the medial and lateral arcuate ligaments. In the abdominal cavity, the dye was found to have spread so widely in the transversalis fascia that the subcostal, iliohypogastric, ilioinguinal, genitofemoral, lateral femoral cutaneous and femoral nerves were involved. We concluded that the dye in the thoracic paravertebral region can enter the abdominal cavity through the medial and lateral arcuate ligaments. This study explained possible fluid communication between the thoracic and lumbar paravertebral regions and confirmed our former clinical observations. The result is important for the future clinical application of paravertebral anesthesia.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 24 (1973), S. 187-196 
    ISSN: 1432-0533
    Keywords: S-100 and 14.3.2 Proteins ; Human Brain Tumors ; Immunofluorescence ; Immunoprecipitation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of the brain specific proteins, S-100 and 14.3.2, was studied in 80 human brain tumors by means of immunofluorescence and immunoprecipitation techniques. The following observations were made: 1. Both the S-100 and 14.3.2 proteins were shown to be present within nerve cells of human frontal lobes. 2. Both the S-100 and the 14.3.2 proteins were shown to be present in the cells of such gliomas as glioblastomas, astrocytomas, spongioblastomas and acoustic neurinomas and some oligodendrogliomas. 3. The 14.3.2 protein, but not the S-100 protein, could be demonstrated in ependymomas, plexus papillomas and chromophobe adenomas of the pituitary and in three polymorphous oligodendrogliomas. 4. None of the proteins were found to be present in necrotic areas of brain tumors or in meningiomas and brain metastases.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-0533
    Keywords: Brain tumors ; Cell separation ; Biochemistry ; Brain specific protein ; GABA ; S-100 protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The heterogeneity of brain tumours, especially in the glioblastoma group, makes biochemical characterization of pieces of the tumours hazardous even with extensive histological controls. This study employs a technique by which separate cell populations are subsequently isolated from the tumours by means of density gradient centrifugation. Cells isolated from glial brain tumours with low density sedimentation rates show the highest levels of glial cell characteristics, i.e. S-100 content and active uptake of the neurotransmitter GABA.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1041
    Keywords: Psychoactive drugs (or psychopharmaca) ; long-term treatment ; haemodynamics ; plasma-noradrenaline ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Haemodynamic effects in patients treated with imipramine and haloperidol were studied at rest and during exercise and were related to the arterial plasma levels of noradrenaline. The results were compared with earlier observations on untreated and chlorpromazine-treated patients studied by the same techniques. After imipramine in a daily dose of 150–350 mg, there was a tendency for the heart rate to increase but no other particular haemodynamic effects were observed. During imipramine treatment noradrenaline levels were not increased compared to the controls, at a work load of less than 900 kpm/min, after which there appeared to be some increase. After haloperidol in a dose of 12–22 mg per day no changes were observed in the circulation or plasma noradrenaline levels. More marked effects on the circulation and plasma noradrenaline levels were found in patients treated with very large doses of chlorpromazine (1800–3600 mg daily). They showed a lower cardiac output, stroke volume and systolic and mean arterial blood pressure during exercise than the other groups. In the chlorpromazine-treated group the heart rate was higher both at rest and during mild exercise. The plasma noradrenaline levels were higher at rest and at all work loads than in the other patients. It may be concluded that the haemodynamic effects of chlorpromazine and its effects on the plasma noradrenaline levels are primarily due to its peripheral α-adrenergic receptor blocking effect, which induces a compensatory increase in sympathetic nerve impulse flow. However, an increased overflow of noradrenaline from the nerve terminals per nerve impulse due to drug effects at the nerve terminal-effector cell level might also contribute to the high plasma levels of noradrenaline found after chlorpromazine treatment.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 84 (1987), S. 48-53 
    ISSN: 0942-0940
    Keywords: Cervical spondylosis ; myelopathy ; radiculopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One hundred and fourteen patients were admitted to our department for evaluation of their cervical spondylogenetic symptoms, including local cervical pain, radiculopathy and myelopathy. This retrospective study gives the results, expressed as improved, unchanged or worse, of anterior surgery, posterior surgery and conservative treatment. Local cervical pain improved in about half of the patients, without any difference between the groups. The effect of surgery on radiculopathy was superior to that of conservative treatment, 71 percent and 74 percent respectively, being improved after anterior and posterior surgery, compared to 19 percent in the conservatively treated group. The majority of patients with myelopathy were treated with posterior surgery and 69 percent had improved. The results were not influenced by the patients age or the duration of symtoms. It is argued that the positive effects of surgery on the radiculopathy are due to a segmental stabilisation rather then to decompression. The immediate post-operative improvement of the myelopathy is undoubtedly caused by the decompression while the long-termed improvement cannot with certainty be attributed to the operation.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Acta neurochirurgica 71 (1984), S. 91-98 
    ISSN: 0942-0940
    Keywords: Cerebral aneurysms ; cerebral arteries ; cerebral haemorrhage ; head injury
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Five cases of traumatic aneurysms of cerebral arteries are presented, two located at the internal carotid artery, and three at peripheral arterial branches. The manifestation of the aneurysm was a delayed neurological deterioration due to bleeding from the aneurysm, 4–35 days (mean 21 days) after the head trauma; four patients had an intracerebral haematoma and one patient had a subarachnoid haemorrhage. One patient died from extensive cerebral injuries with the aneurysm untreated. In four cases the aneurysm was treated surgically. Three patients returned to their former occupation and one patient died from late septic complications. It is concluded that signs of delayed intracranial bleeding after a head trauma should raise the suspicion of an underlying traumatic aneurysm, and in addition to a CT-scan an angiography should be performed.
    Type of Medium: Electronic Resource
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