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  • 1
    Electronic Resource
    Electronic Resource
    Viability of Stored Bone Marrow Colony Forming Units (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 1082-1082 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In spite of the wide use of these techniques in studies which involve a delay between collection of the marrow cells and reinjection, little attention has been given to the effect of temperature, storage and suspending media on the viability of CFUs. A series of determinations was therefore made to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/2191082a0
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  • 2
    Electronic Resource
    Electronic Resource
    Effects of low level radiation upon the hematopoietic stem cell: Implications for leukemogenesis (1987)
    Springer
    Radiation and environmental biophysics 26 (1987), S. 103-114 
    Details
    ISSN: 1432-2099
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Physics
    Notes: Summary These studies have addressed firstly the effect of single small doses of x-rays upon murine hematopoietic stem cells to obtain a better estimate of theD q . It is small, of the order of 20 rad. Secondly, a dose fractionation schedule that does not kill or perturb the kinetics of hemopoietic cell proliferation was sought in order to investigate the leukemogenic potential of low level radiation upon an unperturbed hemopoietic system. Doses used by others in past radiation leukemogenesis studies clearly perturb hemopoiesis and kill a detectable fraction of stem cells. The studies reported herein show that 1.25 rad every day decrease the CFU-S content of bone marrow by the time 80 rads are accumulated. Higher daily doses as used in published studies on radiation leukemogenesis produce greater effects. Studies on the effect of 0.5, 1.0, 2.0, and 3.0 rad 3 times per week are under way. Two rad 3 times per week produced a modest decrease in CFU-S content of bone marrow after an accumulation of 68 rad. With 3.0 rad 3 times per week an accumulation of 102 rad produced a significant decrease in CFU-S content of bone marrow. Dose fractionation at 0.5 and 1.0 rad 3 times per week has not produced a CFU-S depression after accumulation of 17 and 34 rad. Radiation leukemogenesis studies published to date have utilized single doses and chronic exposure schedules that probably have significantly perturbed the kinetics of hematopoietic stem cells. Whether radiation will produce leukemia in animal models with dose schedules that do not perturb kinetics of hematopoietic stem cells remains to be seen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01211405
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  • 3
    Electronic Resource
    Electronic Resource
    A system for simultaneous exposure of small animals to 50-Hz electric and magnetic fields (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Bioelectromagnetics 12 (1991), S. 85-99 
    Details
    ISSN: 0197-8462
    Keywords: 60-Hz electric magnetic ; exposure apparatus ; rodents ; Life and Medical Sciences ; Occupational Health and Environmental Toxicology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Physics
    Notes: Equipment designed for simultaneous exposure of rodents to 60-Hz electric and magnetic fields is described. Three identical systems were constructed, each capable of continuous exposure of 256 rats or 640 mice to a nominal electric field at 〈50 kV/m, and to horizontal and vertical magnetic fields at 〈 1 mT. Design features, construction details, and results of various tests of the systems are described. Tests were made: of phase relations between electric and magnetic fields; of uniformity of electric and magnetic fields; of changes across time in electric-field intensity as a result of animals' soiling of cages and various washing routines; of resistance of bedding material during humid and dry conditions; and of acoustic noise due to background, to field-generation equipment, and to air conditioning equipment. The results demonstrated that fields were effectively generated but that significant and troublesome changes in electric-field intensity occurred because of cage-soiling. However, when cages were frequently cleaned, field intensities were consistent from one exposure to another.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bem.2250120204
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    Paper (German National Licenses)
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