ISSN:
1420-9071
Keywords:
Ansamitocin P-3
;
maytansinoids
;
Claopodium crispifolium
;
Anomodon attenuatus
;
Thuidiaceae
;
mosses
;
cytotoxicity
;
antitumor activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Guided by cytotoxicity, ansamitocin P-3, a maytansinoid, was isolated in very low yield from two members of the moss family Thuidiaceae,Claopodium crispifolium (Hook.) Ren & Card. andAnomodon attenuatus (Hedw.) Hueb. Ansamitocin P-3 showed potent cytotoxicity against the human solid tumor cell lines A-549, HT-29. A possible basis for the occurrence of this compound in mosses is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01955435
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