ISSN:
1432-1041
Keywords:
Key words Yohimbine
;
Alzheimer's disease; 11-hydroxy-yohimbine pharmacokinetics
;
plasma
;
cerebrospinal fluid
;
healthy subjects
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Objective: The plasma and cerebrospinal fluid (CSF) disposition of yohimbine (YO) and 11-hydroxy-yohimbine (11-OH-YO), after oral administration of a single dose of YO (0.65 mg · kg−1) were studied in young and older healthy subjects and in patients with Alzheimer's disease (AD). Results: Plasma disposition of YO displayed large variability; no significant differences among subject groups were observed. In contrast, 11-OH-YO Cmax and AUC were significantly lower in the older normal subjects than in the young normal or AD subjects. A strong positive correlation between CSF and plasma YO concentrations was observed. A weak positive correlation between CSF and plasma concentrations of 11-OH-YO was also observed. CSF to plasma concentration ratios for yohimbine and 11-OH-YO were low (approximately 2%).
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s002280050262
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