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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 153 (1994), S. 702-703 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-198X
    Keywords: Key words Measured nitrogen losses ; Chronic peritoneal dialysis ; Models predicting nitrogen losses Urinary nitrogen losses ; Dialysate nitrogen losses ; Fecal nitrogen losses
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  To develop models to estimate nitrogen (N) losses of children on chronic peritoneal dialysis (CPD) from easily measurable indexes and laboratory tests, we measured the N content and all nitrogenous compounds in dialysate (D), urine (U), and feces over 3 days in 19 pediatric patients on CPD. Total measured N losses (TNm) were 5.56±2.26 g/day (69.9±11.1% in dialysate, 16.3±10.6% in urine, and 13.6±4.6% in feces). Correlation coefficients between measured dialysate and urinary N losses and the single nitrogenous compounds indicated values of over 0.9 only for urea in dialysate and urine; fecal N losses correlated well with body surface area (BSA). Taking into account these correlations, we developed a univariate additive model and three multivariate models to predict total estimated N losses (TNe). The best prediction of TNm was obtained with model 3, which considered not only urea output in dialysate and urine but also dialysate protein loss and BSA: TNe (g/day)=0.03+1.138 UN urea+0.99 DN urea+1.18 BSA+0.965 DN protein. A confirmatory analysis performed on a second group of 23 pediatric patients on CPD, using all four models, showed a higher percentage of studies with a relative difference between TNm and TNe less than 10% for model 3 than for the other models. Thus, N losses of pediatric patients on CPD can be estimated from measured urea and protein losses in dialysate and urea loss in urine, together with BSA.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
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