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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 61 (1983), S. 95-98 
    ISSN: 1432-1440
    Keywords: Thalassemia intermedia ; HbF ; Globin chain synthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Two cases of homozygous β*-thalassemia intermedia have been detected in a Brazilian family of Portuguese and German extraction. The patients are 39 and 43 years old, showed a normal somatic and sexual development and had been transfused only occasionally. Red blood cell morphology was similar to that of thalassemia major, but they had unusually low levels of HbF (5.0% and 6.8%). Globin chain synthesis measured in reticulocytes was in the same range as other β-thalassemia homozygotes. One or both genes in this family must be a particularly mild β-thalassemia allele, despite the fact that the heterozygote members of the family presented clinical, hematological, and biochemical features indistinguishable from the typical heterozygotes for the β-thalassemia trait with high HbA2.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Human genetics 〈Berlin〉 86 (1991), S. 319-320 
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary A family with one homozygote and three heterozygotes for hemoglobin Stanleyville II (α78 Asn→Lys) has been analyzed by α-globin gene mapping. The pattern of restriction fragments with the enzymes BamHI and BglII demonstrated that the α globin variant is associated with a 3.7-kb α-globin gene deletion.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-0789
    Keywords: Composting ; Isoelectric point ; Low molecular weight organic matter ; Sewage sludge ; Fractionating organic matter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary Isoelectric focusing was used to characterize the organic matter of composted and uncomposted sewage sludge. The technique was applied to organic matter extracts and to three fractions, obtained by ultrafiltration, with different molecular weights (〈103, 103–104, 〉104). The elution curves of the extracts through Sephadex G-50 revealed a loss in the proportion of organic matter of low molecular weight as composting progressed, together with an enrichment of the high-molecular-weight proportion. Separation into fractions by controlled ultrafiltration proved to be valid, as deduced from the chromatograms obtained by Sephadex G-50 filtration. The extracts of uncomposted sludge showed a greater number of bands with a low isoelectric point than the composted extract, because there were more acidic molecules in the samples that had not undergone humification. The spectrum corresponding to the extract of the 210-day compost showed greater homogeneity with a lower number of bands. A great part of the organic matter extracted with 0.1 M Na4P2O7 at pH 7.1 corresponded to an intermediate molecular weight. The ampholytes at pH 4–6 gave better resolution than those at pH 3.5–10, in the focusing of fractions with the lowest and the greatest molecular weight. A more homogeneous spectrum was observed for the high-molecular-weight fractions from extracts of the 210-day composted sample; in addition, the bands were displaced towards higher isoelectric points, which indicated that the molecules were more condensed, with a minor content of negatively charged groups and a spectrum similar to that of relative fractions of true humic acids.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1041
    Keywords: cadralazine ; chlorthalidone ; atenolol ; hypertension ; exercise ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The long-term efficacy of a new vasodilator, cadralazine (ISF 2469), and chlorthalidone have been compared in 20 hypertensive patients not adequately controlled by atenolol. After 4 weeks of treatment with atenolol 100 mg once daily, patients whose diastolic blood pressure was 〉95 mmHg were randomly divided into two groups to receive in addition to atenolol, either cadralazine 15 mg once daily or chlorthalidone 25 mg once daily. Both treatments were administered for 6 months. At the end of treatment with atenolol and after 3 and 6 months of combination therapy, blood pressure and heart rate were measured at rest and during bicycle exercise 24 h after the last dose. Compared to atenolol alone, both cadralazine and chlorthalidone caused a significant and similar reduction in resting blood pressure. Both groups showed an increase in diastolic blood pressure during exercise while receiving atenolol alone. The addition of chlorthalidone did not modify the pressor response to exercise, whereas patients taking cadralazine had a decrease in exercise diastolic blood pressure, which was fully evident after 6 months of therapy. The reduction in exercise diastolic blood pressure induced by cadralazine was proportional to the increase in exercise heart rate, suggesting a fall in peripheral vascular resistance. Chlorthalidone caused a significant increase in serum glucose and uric acid and a decrease in K+, whereas no change was observed during cadralazine It is concluded that cadralazine given once a day with atenolol has the same efficacy in controlling blood pressure at rest as the combination of atenolol and chlorthalidone, and in addition it improves the pressor response to dynamic exercise and does not cause unwanted metabolic effects.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 0304-4165
    Keywords: Folate metabolism ; Folate polyglutamate synthesis ; Polyglutamate synthesis ; Vitamin B-12-deficiency
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Medicine , Physics
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Physica C: Superconductivity and its applications 159 (1989), S. 273-276 
    ISSN: 0921-4534
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Xylella fastidiosa is a fastidious, xylem-limited bacterium that causes a range of economically important plant diseases. Here we report the complete genome sequence of X. fastidiosa clone 9a5c, which causes citrus variegated chlorosis—a serious disease of orange trees. The genome ...
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: The Egyptian fruit bat Rousettus aegyptiacus develops severe vitamin B12 deficiency when fed a diet of fresh peeled fruit and water. In a group of bats fed this diet, B12 concentrations in the serum and brain were low, and neurological impairment, evidenced by deficient or absent hindlimb groping or grasping ability and climbing difficulties, was manifest. Control bats fed the identical diet supplemented with B12 showed no such changes. Fatty acid analysis of whole brain homogenates showed a higher level of 20:4 in the deficient group. Phosphatidylcholine showed a marginally higher percentage of 18:3. The total percentage of branched chain fatty acids of phos-phatidylethanolamine was four times higher in deficient brains, comprising 2% of the total. Sphingomyelin showed a slightly higher percentage of 15:0, and a significantly lower percentage of long chain fatty acids C-24 and longer (p 〈 0.01). The compositions of nonhydroxy fatty acids in cerebroside were unchanged. Examination of phospholipids showed that 8.9 ± 0.4% of total phosphorus was present as sphingomyelin in deficient bats, compared with 11.9 ± 1.2% in control animals (p 〈 0.05). There were no statistically significant differences in the concentrations of total brain lipid, protein, phospholipid, glycosphingolipid, cholesterol and plasmalogen between B12-deficient and control bats.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 14 (1987), S. 0 
    ISSN: 1440-1681
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: 1. The reproducibility of pressor response to handgrip performed at different time intervals and with different combinations of the product duration × strength of the exercise was evaluated in 14 normotensive subjects recording blood pressure with a non-invasive automatic device.2. Subjects underwent five consecutive tests (30% of maximal voluntary contraction × 90 s) at 30 min, and 24 h intervals and repeated the test after 12 months. Furthermore, they underwent at 24 h intervals a randomized sequence of handgrip tests whose product strength × duration was combined in order to achieve either a constant or an increasing level of exercise.3. Blood pressure response to exercise performed at 30 min intervals was much less reproducible than that induced by handgrip performed at time intervals ≥ 24 h.4. Increasing gradually the product strength × duration of the handgrip test there was a proportional blood pressure increase, whereas when the product was maintained constant diastolic blood pressure increase was also constant and reproducible within each subject.5. This study shows that it is possible to obtain reproducible diastolic blood pressure responses to handgrip test measuring blood pressure with a non-invasive automatic device when the tests are performed at a time interval of at least 24 h. The choice of the strength and of the duration of the exercise is very important for the reproducibility of the test.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 15 (2001), S. 0 
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Helicobacter pylori has attracted increasing attention among gastroenterologists because of its pathogenic potential, stimulating the search for non-invasive diagnostic tests.〈section xml:id="abs1-2"〉〈title type="main"〉Aims:In this study the efficacy of a new enzyme immunoassay designed to detect H. pylori antigens in stools (HpSA) was evaluated before and after eradication therapy.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:HpSA was performed on stool samples collected from 268 patients whose H. pylori status was defined on the basis of concordant results for the 13C-urea breath test, rapid urease test and histology. The H. pylori-positive patients were treated with a 1-week triple therapy to eradicate the infection. One (T30) and 3 months (T90) after the end of therapy, 13C-urea breath test and HpSA were repeated in the treated patients.〈section xml:id="abs1-4"〉〈title type="main"〉Results:The overall diagnostic accuracy of HpSA at T30 (83%, 95% confidence interval (CI) 77–89%) was significantly lower in comparison to the values obtained at baseline (94%, 95% CI: 91–97%) and at T90 (97%, 95% CI: 94–99%). No significant difference was found between the diagnostic accuracy of HpSA at baseline and at T90 (P=0.253).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:The present data suggest that HpSA provides a low diagnostic accuracy when used shortly after treatment. It needs a longer period of follow-up (8–12 weeks) to reach a reliability comparable to the 13C-urea breath test.
    Type of Medium: Electronic Resource
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