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  • 1
    Electronic Resource
    Electronic Resource
    Antioxidant Toxicity, Toxicological Studies on Sesamol (1958)
    s.l. : American Chemical Society
    Journal of agricultural and food chemistry 6 (1958), S. 600-604 
    Details
    ISSN: 1520-5118
    Source: ACS Legacy Archives
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jf60090a008
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  • 2
    Electronic Resource
    Electronic Resource
    Angiotensin converting enzyme inhibition reduces retinal overexpression of vascular endothelial growth factor and hyperpermeability in experimental diabetes (2000)
    Springer
    Diabetologia 43 (2000), S. 1360-1367 
    Details
    ISSN: 1432-0428
    Keywords: Keywords Retina, vascular endothelial growth factor, permeability, angiotensin converting enzyme.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Aims/hypothesis. Angiotensin converting enzyme (ACE) inhibition has been recently suggested to have retinoprotective actions in diabetic patients but the mechanism of this effect is not known. In vitro, angiotensin II stimulates expression of vascular endothelial growth factor (VEGF), a permeability-inducing and endothelial cell specific angiogenic factor which has been implicated in the pathogenesis of diabetic retinopathy in humans and in experimental animals. We sought to determine the effects of ACE inhibition on retinal VEGF expression and permeability in experimental diabetic retinopathy.¶Methods. Streptozotocin-induced diabetic rats and control animals were assigned at random to receive ACE inhibitor treatment or vehicle. At 24 weeks the retinal VEGF protein gene expression was assessed by northern blot analysis and in situ hybridisation. Retinal permeability to albumin was measured using a double isotope technique.¶Results. Experimental diabetes was associated with cell specific two to fourfold increase in retinal VEGF protein gene expression (p 〈 0.01) and a 2-fold increase in retinal vascular permeability to albumin (p 〈 0.01). The localization of VEGF expression in the retina was not altered in animals with experimental diabetes. Angiotensin converting enzyme inhibitor treatment of diabetic rats reduced diabetes-associated changes in VEGF gene expression and vascular permeability.¶Conclusion/interpretation. These findings implicate the renin-angiotensin system in the VEGF overexpression and hyperpermeability which accompany diabetic retinopathy and provide a potential mechanism for the beneficial effects of ACE inhibition in diabetic retinal disease. [Diabetologia (2000) 43: 1360–1367]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250051539
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  • 3
    Electronic Resource
    Electronic Resource
    Metabotropic Glutamate Receptors Regulate APP Processing in Hippocampal Neurons and Cortical Astrocytes Derived from Fetal Rats (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 777 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: It has previously been shown that stimulation of muscarinic m1 or m3 receptors can, by generating diacylglycerol (DAG) and activating protein kinase C (PKC), accelerate the breakdown of the amyloid precursor protein (APP) to form soluble, non-amyloidogenic peptides (APPs). This relationship has been demonstrated in human glioma and neuroblastoma cells as well as in transfected human embryonic kidney (HEK) cells and PC12 cells.1,2We now provide evidence that stimulation of metabotropic glutamate receptors (mGluRs), which also are coupled to DAG and PKC, similarly accelerates processing of APP into non-amyloidogenic APPs in hippocampal neurons and cortical astrocytes derived from normal fetal rats. The mGluR antagonist, L(+)-2-amino-3-phosphonopropionic acid (L-AP3), and GF 109203X, an inhibitor of PKC, both blocked the release of APPs from hippocampal neurons and astrocytes evoked by glutamate receptor stimulation. Inasmuch as glutamatergic neurons in cortex and hippocampus are known to be damaged in Alzheimer's disease, our findings suggest that amyloid formation may be enhanced by the resulting glutamate deficiency and that selective mGluR agonists may be useful in facilitating synaptic efficacy and treating the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb34443.x
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  • 4
    Electronic Resource
    Electronic Resource
    Electrometer preamplifier for scanning tunneling microscopy (1996)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 67 (1996), S. 2652-2653 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: An optimized current preamplifier, consisting of a shunt resistor followed by a high speed field-effect transistor input instrumentation amplifier, appears suitable for use in scanning tunneling microscopy. The preamplifier has a transimpedance of 100 MΩ, a measured 3 dB bandwidth of 200 kHz, low phase distortion, and excellent noise performance. © 1996 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1147185
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  • 5
    Electronic Resource
    Electronic Resource
    The mitotic index in psoriatic plaques and their response to PUVA therapy (1980)
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 102 (1980), S. 0 
    Details
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The mitotic index of pretreatment plaques of chronic psoriasis was determined before treatment with PUVA. There was a wide variation in mitotic indices in different patients.Treatment was given with UV-A 2 h after oral ingestion of 8-methoxypsoralen (8-MOP) two or three times per week, with increasing doses of UV-A. Patients were considered cleared if there was 95% clearing of all psoriatic plaques.There was no correlation between the mitotic index and the response to treatment, as measured by either the number of joules administered or the number of treatments until the lesions cleared. This suggests that the action of PUVA in psoriasis is not dependent on the amount of increase in epidermal proliferation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2133.1980.tb06552.x
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  • 6
    Electronic Resource
    Electronic Resource
    Absolute Experimental and Theoretical Determination of the Copper-63( n ,2 n )Copper-62 Reaction Cross-section (1967)
    [s.l.] : Nature Publishing Group
    Nature 216 (1967), S. 996-997 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] After Vandenbosch and Huizenga4, the cross-section cr(Jc) for forming any angular momentum state Jc in the compound nucleus is given by p(l£), Ti(E) (1) where I is the spin of the target nucleus, s is the spin and I the angular momentum of the incident particle, and Ti(E) is the barrier ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/216996a0
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  • 7
    Electronic Resource
    Electronic Resource
    Infection of catheterised patients: bacterial colonisation of encrusted Foley catheters shown by scanning electron microscopy (1989)
    Springer
    Urological research 17 (1989), S. 349-352 
    Details
    ISSN: 1434-0879
    Keywords: Urinary infection ; Urinary catheters ; Encrustation ; Bacterial colonisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The surfaces of 32 encrusted urinary catheters were examined by scanning electron microscopy to investigate the association of bacteria with the encrusting deposits. Deposits consisted of struvite crystals surrounded by aggregates of very small crystallites of hydroxyapatite. Underneath these minerals there was a layer of closely packed bacteria. Impressions of bacteria were also observed in hydroxyapatite. Crystals were often engulfed by the bacterial layer, which thus appeared to bind the crystals to each other and to the catheter surface. This thick layer of bacteria associated with crystals may protect both the bacteria from antibiotics and the crystals from acidic bladder washout solutions intended to dissolve them. Furthermore, the existence of this sessile population explains why urease-producing bacteria are not invariably detected in the urine of patients with encrusted catheters. The observation of this bacterial layer (or “biofilm”) by scanning electron microscopy provided direct evidence for infection being implicated in catheter encrustation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510523
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  • 8
    Electronic Resource
    Electronic Resource
    Resistance of catheters coated with a modified hydrogel to encrustation during an in vitro test (1989)
    Springer
    Urological research 17 (1989), S. 353-356 
    Details
    ISSN: 1434-0879
    Keywords: Catheters ; Encrustation ; Hydrogels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Mid-shaft specimens were cut from latex catheters coated with a modified hydrogel, latex catheters coated with silicone elastomer, and 100% silicone catheters. These specimens were subjected to controlled in vitro encrustation conditions. During a test period of 11 weeks, there was no significant difference in the quantities of encrusting deposits formed on the three materials.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510524
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  • 9
    Electronic Resource
    Electronic Resource
    Mammalian Exocrine Secretions XI. Constituents of the Preorbital Secretion of Klipspringer, Oreotragus oreotragus (1997)
    Springer
    Journal of chemical ecology 23 (1997), S. 2383-2400 
    Details
    ISSN: 1573-1561
    Keywords: Oreotragus oreotragus ; klipspringer ; mammalian semiochemicals ; mammalian pheromones ; exocrine secretion ; preorbital secretion ; controlled release ; proteins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The ketones 3-pentanone, 4-methyl-2-pentanone, 5-methyl-3-hexanone, 4-methyl-3-hexanone, and the esters ethyl propanoate, 2-methylpropyl acetate, ethyl 3-methylbutanoate, and 2-methylpropyl propanoate were identified as the only volatile organic constituents of the preorbital secretion of the klipspringer, Oreotragus oreotragus. These compounds are considerably more volatile than those found in the preorbital secretions of other antelopes belonging to the tribe Antelopini. More than 50% of the preorbital secretion consists of proteinaceous material, which probably acts as a controlled-release substance in retarding the evaporation of the volatile constituents of the secretion from territorial marks.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/B:JOEC.0000006681.33646.f4
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  • 10
    Electronic Resource
    Electronic Resource
    Photoelectron spectroscopy of sodium chloride anions with two excess electrons (1993)
    Springer
    The European physical journal 26 (1993), S. 184-186 
    Details
    ISSN: 1434-6079
    Keywords: 36.40
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract Photoelectron spectroscopy measurements of (NaCl)nNa− (n=1–13, except n=10) are reported. The observed electron energy spectra fall into three distinct types, reflecting different correlations between the two excess electrons and ions. Depending on the host clusters' structures, the experimental evidence indicates that the two excess electrons in these sodium chloride clusters could be spin paired, forming a bipolaron or a Na− anion. The two excess electrons could also be spin parallel, forming a double F-center state.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01429138
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