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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 156 (1997), S. 389-391 
    ISSN: 1432-1076
    Keywords: Key words HELLP syndrome  ;  Prematurity  ;   Respiratory distress syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To compare the impact of maternal haemolysis, elevated liver enzymes and low platelets (HELLP) syndrome, uncomplicated hypertension in pregnancy (HIP), and no hypertension (controls) on neonatal morbidity and mortality, 108 infants were matched with respect to gestational age, date of birth, and gender. The HELLP group infants had more grade 3 and 4 respiratory distress syndromes (36%) than the HIP group (19%) or controls (11%). Cardiovascular instability (arterial hypotension, volume resuscitation) was significantly more common in HELLP neonates (20% and 31%) than in HIP infants (9% and 6%) or controls (3% and 9%). Both, HELLP and HIP infants showed a higher incidence of growth retardation than the controls. After 32 weeks of gestation the incidence of severe neonatal morbidity was not different. Conclusion Before 32 weeks of gestation both respir-atory and cardiovascular morbidity and intra-uterine growth retardation associated with HIP is further aggravated by a maternal HELLP syndrome.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 157 (1998), S. 440-440 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 157 (1998), S. 712-714 
    ISSN: 1432-1076
    Keywords: Key words Insulin-like growth factor ; Insulin-like growth factor binding protein 3 ; Growth hormone deficiency ; mesenteric cyst
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 12.5-year-old girl presented with short stature. Insulin-like growth factor 1(IGF-I) and insulin- like growth factor binding protein (IGFBP-3) were below the 0.1 percentile. Growth hormone provocation tests disclosed normal responses to l-arginine and insulin-induced hypoglycaemia. A huge benign mesenteric cyst was discovered by abdominal ultrasound and completely removed. Subsequently, the girl showed a marked catch-up growth; however, IGF-I and IGFBP-3 remained below the 0.1 percentile. Conclusion These observations imply that growth may take place even with very low levels of insulin-like growth factors. The interpretation of low IGF-I and IGFBP-3 levels in short children still requires good clinical judgement and basic knowledge of their biological action.
    Type of Medium: Electronic Resource
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  • 4
    ISSN: 1432-1238
    Keywords: Key words Nitric oxide ; Methemoglobin ; Methemoglobinemia ; Adverse effects ; Ascorbic acid ; Glutathione
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The objective of the present study was to investigate the treatment of nitric oxide (NO)-induced methemoglobinemia by ascorbate and its consequences on red blood cell (RBC) glutathione in vitro. RBC were obtained from five healthy volunteers. The following experiments were carried out: (1) After methemoglobin generation by NO, ascorbate was added (2) RBC were simultaneously exposed to NO and ascorbate (3) Methemoglobin was generated by NO, ascorbate was added and incubation with NO continued. (1) After discontinuation of NO, the mean half life for methemoglobin was reduced from 195 min (controls) to 60 min (10 mM ascorbate) in a dose-dependent manner. (2) Methemoglobin formation after 3 h of NO exposure was 2.7 ± 0.3 % in controls and 1.8 ± 0.1 % with 10 mM ascorbate (p 〈 0.01). (3) Further methemoglobin formation was inhibited only by 10 mM ascorbate (p 〈 0.001). NO incubation did not affect RBC glutathione (86.5 ± 19.6 and 86.5 ± 19.6 mg/l, respectively). Treatment with 10 mM ascorbate significantly decreased glutathione (p 〈 0.002). In vitro, NO-induced methemoglobin formation is significantly decreased only by a high (10 mM) ascorbate concentration. Glutathione, critical for ascorbate activity, is not influenced by NO.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-2013
    Keywords: Gonadotropins hCG/LH receptor Pregnancy Utero-placental perfusion Vascular endothelium Vascular smooth muscle
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract. Membrane receptors for human chorionic gonadotropin (hCG) are expressed in a variety of steroidogenic cells, and also in extragonadal tissues such as vessels of the female genital tract. We examined the possible contribution of hCG to the endocrine control of prearteriolar mesenteric and uterine vessels before and during pregnancy. Lumen diameters of isolated pressurized resistance arteries from Sprague-Dawley rats were measured using a video-electronic system. hCG produced marked and dose-dependent vasodilation. Uterine radial arteries were found to be highly sensitive to hCG (EC50≅60 mU/ml) before and throughout gestation. Second-order mesenteric arteries from nonpregnant animals were even more sensitive (EC50=38 mU/ml), but, in these vessels, responsiveness to hCG was significantly attenuated by the pregnant state. Mechanical removal of the vascular endothelium did not reduce the degree of vasodilation mediated by hCG. The expression of hCG receptor mRNA in intact vessels could be demonstrated using reverse transcriptase polymerase chain reaction (RT-PCR). hCG appears to be an important embryonic signal, which could trigger adaptive cardiovascular changes in early pregnancy, simultaneously preserving a sufficient utero-placental perfusion during the entire gestation period by an endothelium-independent mechanism.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1238
    Keywords: Key words Intensive care ; Critical care ; Acute respiratory distress syndrome ; Persistent pulmonary hypertension of the newborn ; Feedback inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: To examine the kinetics of successful nitric oxide (NO) withdrawal in vivo and in vitro.¶Design and setting: Prospective study in a university pediatric intensive care ward and research laboratory.¶Patients and materials: Nineteen patients with acute respiratory distress syndrome (ARDS) or persistent pulmonary hypertension of the newborn (PPHN). Primary porcine pulmonary artery cells in vitro.¶Interventions: NO inhalation and withdrawal in patients; exposure to NO donor sodium nitroprusside (SNP) and gaseous NO in vitro.¶Measurements and results: In patients: a slight, but significant, increase of oxygenation index (OI) from 4.57 ± 0.24 cmH2O/torr (mean ± SEM) to 4.90 ± 0.26 cmH2O/torr after withdrawal of NO (p 〈 0.001). Recovery of OI (4.43 ± 0.23 cmH2O/torr) 30 min after weaning, a significant drop after 4 h (3.72 ± 0.17 cmH2O/torr; p 〈 0.001), values restored after 12 h.¶In vitro: NO synthase (NOS) activity was significantly lower in SNP-incubated cells (20.0 ± 4.0 μm/min) than in control cells (37.6 ± 7.0 μm/min; p 〈 0.05). Thirty minutes after SNP withdrawal there was NOS activity of 35.8 ± 10.0 μm/min with a significant increase by 4 h (p 〈 0.05). No alteration of endothelial NOS (ENOS) mRNA expression by NO (Northern Blot).¶Conclusion: In patients there is a slight, but significant, reversible increase of OI after successful weaning from NO. In vitro, NO leads to a reversible decrease of ENOS activity on a post mRNA level, resembling clinical observations.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1433-0474
    Keywords: Schlüsselwörter ; Akutes Nierenversagen ; Borsäurevergiftung ; Eosinophilie ; Erythem ; Hämodialyse ; Key words ; Acute renal failure ; Borate ; Eosinophilia ; Erythema ; Hemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Today borate is a rarely used agent. Only few reports about borate intoxication have been published within the last few years. Acute renal failure and skin-lesions are well-known symptoms of an acute borate intoxication. We report on a 14 year old girl with a suicidal ingestion of about 4 g borate. Twelve hours later the girl developed an acute renal failure, which was compensated by hemodialysis. Twenty five days later an allergic-toxic erythema appeared (”boiled lobster syndrome”) in parallel with an eosinophilia of 50% (5184 eosinophiles/µl) in the peripheral blood smear. Under symptomatic therapy eosinophilia and other symptoms resolved completely. Discussion: The very late development of the typical erythema is as remarkable as the unusual, enormous eosinophilia, which has not been reported before in this context. Mostly, mild courses are seen. Our patient recovered completely.
    Notes: Zusammenfassung Borsäure wird heute sehr selten benutzt. Entsprechend sind die Erfahrungen mit Borsäureintoxikationen in den letzten Jahren gering. Akutes Nierenversagen und desquamative Hauterosionen sind bekannte Intoxikationserscheinungen. Ein 14jähriges Mädchen entwickelte 12 h nach der Ingestion von etwa 4 g Borsäure in suizidaler Absicht ein akutes Hämodialyse-pflichtiges Nierenversagen mit Anurie über 14 Tage. 25 Tage nach der Ingestion kam es zu einem desquamativen Exanthem (Boiled-lobster-Syndrom) sowie zu einer ausgeprägten Eosinophilie von 5184/µl bei einer Gesamtleukozytenzahl von 10800/µl. Unter symptomatischer Therapie kam es zu einer schnellen und vollständigen Remission der klinischen Symptomatik sowie der Eosinophilie. Diskussion: Das späte Auftreten des typischen Exanthems sowie die ausgeprägte Eosinophilie sind bemerkenswert und in diesem Ausmaß bisher noch nicht beschrieben.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 220 (1934), S. 199-200 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 222 (1935), S. 107-112 
    ISSN: 0863-1786
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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