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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 36 (1989), S. 575-578 
    ISSN: 1432-1041
    Keywords: bunazosin ; hypertension ; alpha1-adrenoceptor blocker ; blood pressure ; renal blood flow ; renal function ; renin ; aldosterone ; atrial natriuretic peptide
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The renal and hormonal effects of the α1-adrenoceptor blocker bunazosin were examined in 6 patients with essential hypertension. Oral bunazosin for 4 to 12 weeks significantly decreased mean blood pressure by 10%, increased effective renal blood flow and creatinine clearance by 34% and 37%, respectively, the plasma norepinephrine concentration was elevated by 60%, and the plasma atrial natriuretic peptide level was lowered by 22%. The plasma renin activity and aldosterone concentration were unchanged. Thus, a moderate reduction in blood pressure was produced by bunazosin treatment while maintaining renal perfusion.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 3
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    New York, N.Y. : Periodicals Archive Online (PAO)
    Sex Roles. 22:3/4 (1990:Feb.) 213 
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 358 (1998), S. 367-373 
    ISSN: 1432-1912
    Keywords: Key words Sodium azide ; Micropuncture ; Loop of Henle ; Thick ascending limb ; Tubuloglomerular feedback ; Furosemide ; Nitric oxide ; Metabolic inhibition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Sodium azide (NaN3, AZ) is a potent inhibitor and uncoupler of oxidative phosphorylation as well as a nitrovasodilator after being converted to nitric oxide (NO). We studied the effect of intratubular application of AZ on loop of Henle reabsorption and tubuloglomerular feedback (TGF) employing renal micropuncture experiments in nephrons with superficial glomeruli of anesthetized Munich-Wistar-Frömter rats. During perfusion of Henle’s loop downstream from an obstructing wax block, AZ (3×10–5 mol/l and 3×10–4 mol/l) concentration-dependently increased early distal tubular flow rate and sodium and potassium ion concentration (VED, [Na+]ED, [K+]ED). In comparison, application of furosemide (10–4 mol/l), the action of which is restricted to the water-impermeable thick ascending limb of Henle’s loop (TALH) and the macula densa, similarly increased [Na+]ED and [K+]ED, but did not affect VED. The effect of AZ on loop of Henle reabsorption appeared to be predominantly localized upstream to the TALH since (1) AZ significantly inhibited net fluid reabsorption (the latter being completely abolished at 3×10–4 mol/l), (2) the effect of AZ on [Na+]ED and [K+]ED could be mimicked by perfusing the Henle’s loop at a flow rate that caused a comparable increase in VED (reflecting a comparable load to TALH), and (3) the effects of AZ and furosemide were additive. In spite of the increase in [Na+]ED and [K+]ED, intratubular application of AZ caused a concentration-dependent inhibition of TGF response, the latter being assessed as the fall in early proximal tubular stop flow pressure during perfusion of Henle’s loop at increasing flow rate. Like AZ and furosemide, the NO donor sodium nitroprusside (10–4 mol/l) blunted the TGF response, but in contrast to furosemide or AZ, it caused a minor decrease in VED, without changing [Na+]ED or [K+]ED. The inhibitory effect of AZ on TGF was abolished by the NO scavenger carboxy PTIO. In summary, AZ inhibits both reabsorption in the water-permeable segment of Henle’s loop and the TGF response. The effect on reabsorption may be linked to metabolic inhibition rather than NO release, whereas the blunted TGF response appears to involve conversion to NO.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Sex roles 22 (1990), S. 213-236 
    ISSN: 1573-2762
    Source: Springer Online Journal Archives 1860-2000
    Topics: Sociology
    Notes: Abstract Gender differences in health status and illness behavior have been explained in terms of sex roles and gender-related personality traits. It may be hypothesized that in a community that is committed to gender-negating ideology, where men and women alike participate in public life, and housework and child care largely collectivized, gender health differences will disappear. The kibbutz movement is committed to the ideology of the emancipation of women: women fully participate in the labor force and decision making. Nonetheless, women on the kibbutz are responsible for the housework and are concentrated in feminine occupations. The kibbutz, then, allows us to test the relationship between gender ideology and participation in public life vs. gender roles and tasks, and health. The health behavior, health status, and illness behavior of 230 members of two kibbutzim, one religious and one secular, were studied. Men and women report similar health status and illness behavior; parental status is not related to health; and marital status is related to psychological distress only. Similar patterns were observed for the secular kibbutz and the religious one despite the more traditional division of labor in the latter.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1569-8041
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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