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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of ticarcillin in man (1982)
    Springer
    European journal of clinical pharmacology 23 (1982), S. 167-172 
    Details
    ISSN: 1432-1041
    Keywords: ticarcillin ; probenecid ; excretion ; pharmacokinetics ; automated chemical assay method
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The excretion of radioactivity has been investigated in 3 healthy volunteers following rapid intravenous administration of 5 g of [35S]-ticarcillin. The radioactive dose was rapidly and completely excreted, since within 4 days 98.5% was recovered, 95% in the urine and 3.5% in faeces. All the urine radioactivity was accounted for as ticarcillin and its penicilloic acid. Plasma and urine samples collected from the volunteers at frequent intervals during the first 6 h of the experiment were assayed for penicillin by an automated chemical method and also for radioactivity. The results obtained by the chemical autoanalyser method were in excellent agreement with the plasma levels of radioactivity. From the data it was possible to calculate the renal clearance of the penicillin, a mean value of 104 ml/min was observed in the 3 volunteers. A further three volunteers were dosed intravenously with a 5 g bolus of non-radiolabelled ticarcillin in a cross-over study with and without predosing with probenecid. Serum samples were analysed by the chemical method for penicillin and the data subjected to pharmacokinetic analysis using a two compartment open model. The results indicate a shift of the distribution equilibrium of ticarcillin from the serum into the peripheral compartment after predosing with probenecid. Furthermore, the mean half-life of ticarcillin in the serum of the three volunteers was significantly increased from 1.3 h to 2.1 h by predosing with probenecid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00545973
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  • 2
    Electronic Resource
    Electronic Resource
    Use of limestone wastes from metal mining as agricultural lime: potential heavy metal limitations (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Soil use and management 9 (1993), S. 0 
    Details
    ISSN: 1475-2743
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract. Finely ground limestone waste from lead mining is discarded as useless but could be a valuable alternative to agricultural limestone. A glasshouse pot experiment established that it is an effective liming material. Two kinds were used: one from north Wales (HMT) represented metal-rich waste produced by the older water-gravity separation of ores; the other (NLB) was a modern flotation tailings. A commercial lime (CLS) was used for comparison. The materials were applied to an acid soil in quantities sufficient to raise the pH to 7 (single liming) and at much greater rates equivalent to annual limings for 369 years. All treatments were replicated five times and the soil/lime mixtures were analysed for EDTA-extractable lead, zinc and cadmium. Radish was grown as the test plant and hypocotyl and leaf tissue were analysed for the same metals. The larger additions of HMT and NLB caused chlorosis and decreased yields. The cadmium and lead concentrations of leaves and hypocotyls suggested that the HMT material could be safely applied to soil annually for 79 years and NLB for 277 years. It is concluded that NLB can be used as agricultural limestone.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1475-2743.1993.tb00928.x
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  • 3
    Electronic Resource
    Electronic Resource
    Greater contribution to blood lead from water than from air (1984)
    [s.l.] : Nature Publishing Group
    Nature 310 (1984), S. 138-140 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Our surveys were based on representative samples of women in five areas chosen to represent different exposures to traffic: Cardiff, a major city which has 30,000-40,000 vehicles per day on the major roads; dwellings within 100m of the elevated motorway in Port Talbot, with around 27,000 vehicles ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/310138a0
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  • 4
    Electronic Resource
    Electronic Resource
    The epidemiology of dental caries in relation to environmental trace elements (1987)
    Springer
    Cellular and molecular life sciences 43 (1987), S. 87-92 
    Details
    ISSN: 1420-9071
    Keywords: Apatite ; caries ; enamel ; fluorine ; lead ; molybdenum ; selenium ; trace metals ; vegetables ; water
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary This paper reviews the influence of the geochemical environment on the epidemiology of human dental caries. The best documented association is that between water borne fluoride and reduced caries prevalence. The influence of fluoride was first reported during the early decades of this century in Colorado, USA, and led to the fluoridation of some public water supplies in several countries. In all cases, fluoridation has been followed by significant improvements in dental health and no adverse effects in general health. Other trace elements in food and water have now been linked with dental caries. Molybdenum has been associated with reduced caries prevalence whereas selenium and lead appear to have adverse effects. Cavity formation in teeth probably involves a localised dissolution of the enamel surface by the products of bacterial activity. It is possible that the incorporation of trace metals into the apatite microcrystals of enamel may alter their physical properties, especially solubility, and hence their susceptibility to degradation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01940359
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  • 5
    Electronic Resource
    Electronic Resource
    Book reviews (1991)
    Springer
    Environmental geochemistry and health 13 (1991), S. 39-40 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01783495
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  • 6
    Electronic Resource
    Electronic Resource
    Editorial (1988)
    Springer
    Environmental geochemistry and health 10 (1988), S. 70-70 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01758670
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  • 7
    Electronic Resource
    Electronic Resource
    Radioactivity in the environment (1991)
    Springer
    Environmental geochemistry and health 13 (1991), S. 138-138 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01758543
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  • 8
    Electronic Resource
    Electronic Resource
    Editorial (1992)
    Springer
    Environmental geochemistry and health 14 (1992), S. 34-34 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01783624
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  • 9
    Electronic Resource
    Electronic Resource
    Book reviews (1993)
    Springer
    Environmental geochemistry and health 15 (1993), S. 55-56 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00146293
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  • 10
    Electronic Resource
    Electronic Resource
    Book reviews (1990)
    Springer
    Environmental geochemistry and health 12 (1990), S. 259-264 
    Details
    ISSN: 1573-2983
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01782989
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