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  • 1
    Electronic Resource
    Electronic Resource
    Improvements in Isotopic Carbon Assay and Chemical Analysis of Organic Compounds by Dry Combustion (1955)
    s.l. : American Chemical Society
    Analytical chemistry 27 (1955), S. 1935-1939 
    Details
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ac60108a025
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  • 2
    Electronic Resource
    Electronic Resource
    Height and glucose tolerance in adult subjects (1991)
    Springer
    Diabetologia 34 (1991), S. 531-533 
    Details
    ISSN: 1432-0428
    Keywords: Type 2 (non-insulin-dependent) diabetes mellitus ; impaired glucose tolerance ; glucose tolerance ; oral glucose tolerance test ; epidemiology ; height ; body mass index ; waist/hip ratio
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a prospective study concerning the pathogenesis of impaired glucose tolerance and Type 2 (non-insulindependent) diabetes mellitus, 346 subjects with no clinical history of diabetes were given a standard 75 g oral glucose tolerance test. The expected positive associations between 120-min plasma glucose concentration and age and body mass index were observed in both sexes and between 120-min plasma glucose and waist/hip ratio in male subjects. An unexpected negative correlation was found between 120-min plasma glucose and height in both sexes (r = − 0.23, (95% confidence interval, − 0.38− − 0.07) p〈0.007 for male subjects and r = − 0.24, (− 0.37− − 0.11) p〈0.006 for female subjects). These negative associations with height remained significant after controlling for age and body mass index in male subjects but not in female subjects. In the latter a highly significant negative relationship of height with age was recorded (r = − 0.33, (− 0.45− − 0.20) p〈0.0001). Comparison between individuals with impaired glucose tolerance and control subjects matched for sex, age and body mass index showed that subjects with impaired glucose tolerance are significantly shorter. Mean (± SEM) height in the male subjects with impaired glucose tolerance (n = 29) was 173.4 ± 1.1 cm vs 176.9 ± 1.3 cm in control subjects, p = 0.02. In the female subjects(n = 39)mean(±SEM)height was 159.4±1.0 cm vs 162.4±1.0 cm in control subjects, p = 0.02. The negative relationship between height and glucose tolerance is a new epidemiological observation which has not been previously reported. One possible reason for this is that the most commonly used anthropometric index, body mass index, eliminates height as an independent analytical variable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403292
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  • 3
    Electronic Resource
    Electronic Resource
    Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids (1994)
    Springer
    Diabetologia 37 (1994), S. 889-896 
    Details
    ISSN: 1432-0428
    Keywords: Key words Non-insulin-dependent diabetes mellitus ; impaired glucose tolerance ; hypertriglyceridaemia ; hyperinsulinaemia ; non-esterified fatty acid.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although plasma insulin and triglyceride concentrations are positively correlated in many studies, the relationships between insulin resistance, insulin secretion and hypertriglyceridaemia remain unclear. To study these associations, subjects between the ages of 40 and 64 were randomly selected from a general practice register and invited to attend for a standard oral glucose tolerance test for measurement of insulin, triglyceride and non-esterified fatty acid concentrations. The study comprised 1122 subjects who were not previously known to have diabetes and who completed the test. Using the World Health Organisation criteria, 51 subjects were classified to have non-insulin-dependent diabetes mellitus, 188 had impaired glucose tolerance and 883 subjects had normal glucose tolerance. Triglyceride concentrations in subjects with glucose intolerance were elevated compared to those in control subjects, even after adjustment for age, obesity and gender (p 〈 0.001 for subjects with diabetes and p 〈 0.01 for those with impaired glucose tolerance compared to normal subjects). In separate multiple regression analyses for males and females, the most important determinants of the plasma triglyceride concentration were the area under the non-esterified fatty acid suppression curve (p 〈 0.001 in both genders) and the waist-hip ratio (p 〈 0.001 for men and 〈 0.01 for women). The fasting insulin concentration was independently associated with triglyceride concentration in women only (p 〈 0.01). The most important determinant of the area under the non-esterified fatty acid suppression curve in men was the 30-min insulin increment, a measure of insulin secretion, (p 〈 0.001) whereas for women age (p 〈 0.001) and the body mass index (p 〈 0.01) were the most important. [Diabetologia (1994) 37: 889–896]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400944
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  • 4
    Electronic Resource
    Electronic Resource
    Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids (1994)
    Springer
    Diabetologia 37 (1994), S. 889-896 
    Details
    ISSN: 1432-0428
    Keywords: Non-insulin-dependent diabetes mellitus ; impaired glucose tolerance ; hypertriglyceridaemia ; hyperinsulinaemia ; non-esterified fatty acid
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Although plasma insulin and triglyceride concentrations are positively correlated in many studies, the relationships between insulin resistance, insulin secretion and hypertriglyceridaemia remain unclear. To study these associations, subjects between the ages of 40 and 64 were randomly selected from a general practice register and invited to attend for a standard oral glucose tolerance test for measurement of insulin, triglyceride and non-esterified fatty acid concentrations. The study comprised 1122 subjects who were not previously known to have diabetes and who completed the test. Using the World Health Organisation criteria, 51 subjects were classified to have non-insulin-dependent diabetes mellitus, 188 had impaired glucose tolerance and 883 subjects had normal glucose tolerance. Triglyceride concentrations in subjects with glucose intolerance were elevated compared to those in control subjects, even after adjustment for age, obesity and gender (p〈0.001 for subjects with diabetes and p〈0.01 for those with impaired glucose tolerance compared to normal subjects). In separate multiple regression analyses for males and females, the most important determinants of the plasma triglyceride concentration were the area under the non-esterified fatty acid suppression curve (p〈0.001 in both genders) and the waist-hip ratio (p〈0.001 for men and 〈0.01 for women). The fasting insulin concentration was independently associated with triglyceride concentration in women only (p〈0.01). The most important determinant of the area under the non-esterified fatty acid suppression curve in men was the 30-min insulin increment, a measure of insulin secretion, (p〈0.001) whereas for women age (p〈0.001) and the body mass index (p〈0.01) were the most important.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400944
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  • 5
    Electronic Resource
    Electronic Resource
    Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance (1995)
    Springer
    Diabetologia 38 (1995), S. 1358-1366 
    Details
    ISSN: 1432-0428
    Keywords: Hypertriglyceridaemia ; non-esterified fatty acid ; ischaemic heart disease ; smoking
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate causes of increased triglyceride concentrations in subjects with normal glucose tolerance (determined by oral glucose tolerance testing using World Health Organization criteria) 883 healthy subjects (389 men and 494 women) between 40 and 65 years of age were studied. Subjects were divided by gender into four groups according to 120-min glucose concentrations. Individuals in the highest quartile of glucose concentration had the highest mean triglyceride concentrations (p〈0.0001) and highest mean non-esterified fatty acid (NEFA) concentrations (p〈0.0001). There was also a clustering of cardiovascular risk factors normally associated with the insulin resistance syndrome in subjects in this group. Regression analysis showed that the most important determinants of triglyceride levels were smoking (men p=0.001, women p=0.005), waist:hip ratio (men p=0.01, women p〈0.001) and NEFA suppression (men p=0.02, women p=0.005). NEFAs suppressed 16.7% in women compared to 2.4% in men during the first 30 min of the oral glucose tolerance test (p〈0.001). These results show that a clustering of cardiovascular risk factors associated with decreased NEFA suppression occurs in a sub-group of subjects with normal glucose tolerance and that the pattern of NEFA suppression differs between men and women.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00401770
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  • 6
    Electronic Resource
    Electronic Resource
    Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance (1995)
    Springer
    Diabetologia 38 (1995), S. 1358-1366 
    Details
    ISSN: 1432-0428
    Keywords: Key words Hypertriglyceridaemia ; non-esterified fatty acid ; ischaemic heart disease ; smoking.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To investigate causes of increased triglyceride concentrations in subjects with normal glucose tolerance (determined by oral glucose tolerance testing using World Health Organization criteria) 883 healthy subjects (389 men and 494 women) between 40 and 65 years of age were studied. Subjects were divided by gender into four groups according to 120-min glucose concentrations. Individuals in the highest quartile of glucose concentration had the highest mean triglyceride concentrations (p 〈 0.0001) and highest mean non-esterified fatty acid (NEFA) concentrations (p 〈 0.0001). There was also a clustering of cardiovascular risk factors normally associated with the insulin resistance syndrome in subjects in this group. Regression analysis showed that the most important determinants of triglyceride levels were smoking (men p = 0.001, women p = 0.005), waist:hip ratio (men p = 0.01, women p 〈 0.001) and NEFA suppression (men p = 0.02, women p = 0.005). NEFAs suppressed 16.7 % in women compared to 2.4 % in men during the first 30 min of the oral glucose tolerance test (p 〈 0.001). These results show that a clustering of cardiovascular risk factors associated with decreased NEFA suppression occurs in a sub-group of subjects with normal glucose tolerance and that the pattern of NEFA suppression differs between men and women. [Diabetologia (1995) 38: 1358–1366]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001250050435
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  • 7
    Electronic Resource
    Electronic Resource
    Storage of organochlorine insecticides in adipose tissue of ugandans (1974)
    Springer
    Bulletin of environmental contamination and toxicology 12 (1974), S. 501-508 
    Details
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Notes: Summary In the framework of a WHO — International Agency Program for Research on Cancer, people from five African, three Asian, and two South American countries were studied for the storage level of organochlorine insecticide storage in the adipose tissue of Ugandans. Specimens of adipose tissue (75) collected during autopsy from Ugandans living in the Kampala area, who had no occupational exposure to organochlorine insecticides were analyzed by the gas chromatographic method for organochlorine insecticides (DDT-derived material, the beta isomer of BHC, dieldrin and heptachlor epoxide). In the 0–4 year age group, DDT-derived material averaged 2.3 ppm; DDT constituted 59.6% of total DDT. In the 5–24 year age group, total DDT averaged 3.84 ppm. DDE constituted 50.2% of total DDT. In the 25–44 year age group, total DDT averaged 2.9 ppm DDE constituted 63.2% of total DDT. In the 45 and over age group, total DDT averaged 2.4 ppm and DDE constituted 53.6% of total DDT. Dieldrin and the beta isomer of BHC were stored at levels below 0.1 ppm and heptachlor epoxide below levels of 0.2 ppm. Males generally stored more OCI than females. Lower storage levels of total DDT were observed in the group aged 45 years and over, when compared to the 5–24 and 25–44 year age groups. In comparison to other populations in Africa, Asia, and South America, people from Uganda stored the lowest amount of OCI. It is proposed that the 25–44 year age group may characterise the OCI storage level of a community since in this age group DDT-derived material tends to be stored at higher concentrations in the adipose tissue of people in several countries, when compared to lower age groups. (In the over 45 year age groups the level of DDT-derived material varies from country to country being higher or lower than in the 25–44 year age group.)
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01684989
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  • 8
    Electronic Resource
    Electronic Resource
    The impact of screening on the incidence of cervical cancer in England and Wales (1985)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 92 (1985), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Summary. Age-specific incidence curves for clinical cancer of the cervix in England and Wales show progressive changes over the period 1963–1978; in particular, a large reduction in incidence is seen in the age group 35–54. Since screening on any scale began in the early 1960s, we have investigated how much of this reduction in incidence in the middle age range can be attributed to detection of pre-invasive disease. Data on registrations of in-situ cancer have been used to estimate the patterns that might have been observed in the absence of screening. The results indicate clear cohort effects on incidence, with rising rates in the generations born 1906–1921 and since 1931, with a fall in the decade between. In addition to this, screening has probably led to a substantial reduction in the number of cases of clinical cancer in women aged 35–54, but has had little effect over the age of 60 where virtually no screening has been performed. Below age 35 the observed increase in incidence may be considerably less than it would have been in the absence of screening.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1985.tb01067.x
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  • 9
    Electronic Resource
    Electronic Resource
    Cervical Cancer and Cytology Screening in NewZealand. (1979)
    Oxford, UK : Blackwell Publishing Ltd
    BJOG 86 (1979), S. 0 
    Details
    ISSN: 1471-0528
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-0528.1979.tb10836.x
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    Paper (German National Licenses)
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  • 10
    Electronic Resource
    Electronic Resource
    Diffusion Approximation to Countercurrent Distribution Theory (1966)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 5 (1966), S. 499-500 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i160020a011
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