ISSN:
1744-313X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Biology
,
Medicine
Notes:
It is well known that the major histocompatibility system (MHS) has unique properties pertaining to antigenic strength (Démant, 1973). In the 1973 and 1975 Workshops we investigated alloimmune interactions to try to find out which MHS genes are involved and how they confer antigenic strength. We found that in several models there are special antigenic strength conferring and/or controlling genes, that there are probably several such genes unique for each model, situated throughout the mouse MHS (H-2 complex). For example, the cell mediated lympholysis (CML) controlling genes, the Effector Cell Stimulating (ECS) genes, conferring strength against K and D region antigens are in the I region but separate from the I-A Lad genes (Festenstein et al., 1974) while the allograft controlling genes, for various rejection models, are in the D region as well as the I region (Festenstein et al., 1975). This is an attempt to bring together the data from these various models to formulate a functional concept of antigenic strength, in relation to its genetic basis.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1744-313X.1975.tb00535.x
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