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  • 1
    Electronic Resource
    Electronic Resource
    Zur Morphologie der Kittsubstanz-Fibrillen-Beziehung nach Einwirkung von Fibrin bzw. Fibrinogen auf die Kollagenfaser (1966)
    Springer
    Journal of molecular medicine 44 (1966), S. 530-530 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary By collagenous fibres of rabbits' skin we could show, that after i. c. injection of fibrinogen, its molecules are incorporated into submicroscopical lacunas of peri- and inter-microfibrillar ground substance. The principle of formalgenesis of this reaction is exposed for discussion.
    Notes: Zusammenfassung An Kollagenfasern der Kaninchenhaut wurde nach Fibrinogeninjektion polarisations- und fluorescenzmikroskopisch der Nachweis erbracht, daß sich Fibrinogen gerichtet in das submikroskopische Lückenwerk der Faser eingelagert und zu einer Desintegration der Mikrofibrillen führt. Das zugrunde liegende pathogenetische Prinzip wird dargestellt.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727584
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  • 2
    Electronic Resource
    Electronic Resource
    Über den Einfluß von Actinomycin D auf die Acridinfluorescenz von L-Zellen in vitro (1969)
    Springer
    Journal of molecular medicine 47 (1969), S. 384-385 
    Details
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary L 5178-Y-cells were incubated with actinomycin D/C1 (AMD) up to 48 houres and stained with acridine orange (AO). It has been shown, that cells without AMD-treatment are characterized by red fluorescence in nuclei and cytoplasm, which is typical for dye-binding RNA-PO 4 − groups. With increasing duration of AMD incubation this fluorescence decreases, so that after 48 h nearly all cells are showing a green fluorescence, typical for DNA-PO 4 − groups. Extraction of RNA by RNase is followed by the same change in fluorescence emission. Inactivation of cells by ethanol stopes the change of AO-fluorescence emission. Since red AO-fluorescence seems to be typical for dye-binding to RNA whereas green AO-fluorescence characterized free DNA-PO 4 − groups, this phenomenon is assumed to be typical for a strong decrease of nuclear and cytoplasmic RNA in cells after incubation with actinomycin.
    Notes: Zusammenfassung L 5178-Y-Zellen wurden bis zu 48 Std mit Actinomycin D (C1) inkubiert und auf ihre Sekundärfluorescenz nach Acridinorange-Fluorochromierung untersucht. Dabei zeigte sich, daß vor Actinomycinzugabe nahezu alle Zellen eine kupferrote Fluorescenz in Kern und Cytoplasma aufweisen. Mit zunehmender Inkubationsdauer nimmt der Anteil der rot fluorescierenden Zellen stetig ab, während der der Zellen mit ausschließlich grüner Sekundärfluorescenz zunimmt. Herauslösen der Ribonucleinsäuren durch RNase-Behandlung ruft den gleichen Farbwechsel hervor. Nach 48 Std fluorescieren nahezu alle Zellen grün. Die Änderung des Farbwertes läßt sich durch Abtöten der Zellen mit Äthanol unterbrechen und fixieren. Die Befunde sprechen für eine Abnahme der nucleären und cytoplasmatischen Ribonucleinsäure nach Inkubation mit Actinomycin.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01734763
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  • 3
    Electronic Resource
    Electronic Resource
    Lead content of fetal tissues after maternal intoxication (1986)
    Springer
    Archives of toxicology 58 (1986), S. 203-204 
    Details
    ISSN: 1432-0738
    Keywords: Lead ; Teratogenity ; Blood level ; Acute intoxication ; Fetal tissue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A female employee was exposed to lead dust for 8 h daily from 4. 5. 1982 to 20. 5. 1982. During this time conception occurred (1st day of last menses 4. 5. 82). Acute symptoms of lead intoxication were not observed in this subject but were in other employees. Measurements of lead content were started after the end of exposure and continued for 6 months until normal values were obtained. Because of the half-life of nearly 20 days for lead elimination from blood the estimated body burden at the end of exposure was about 1200 ppb. The fetal tissue samples contained between 0.4 (brain) and 7.9 (liver) μg lead/g dry weight. The fetal lead was mainly stored in bone, blood and liver. From the results given a delayed elimination of fetal lead is suggested.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00340983
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  • 4
    Electronic Resource
    Electronic Resource
    Lymphocyte subpopulations in solvent-exposed workers (1986)
    Springer
    International archives of occupational and environmental health 57 (1986), S. 109-115 
    Details
    ISSN: 1432-1246
    Keywords: Floorers ; Organic solvents ; Lymphocytosis ; Lymphocyte subpopulations ; Cellular immune response
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To estimate the cellular immune response of workers highly exposed to mixtures of organic solvents, subpopulations of peripheral blood lymphocytes (PBLs) were analyzed. For this, the PBLs of nine floorers (aged 25–58 years, exposure time 8–35 years) were subsequently labelled with monoclonal antibodies OKT 4, OKT 8, OKT 11, anti-Leu 7 and anti-Leu 12. Analysis was made by a FACS IV cell sorter (Becton-Dickinson, USA). The control group consisted of matched pairs of healthy donors. In the exposed group we found a decrease in the OKT 11 (all) T cell fraction, a decrease in the OKT 4 helper cells, an increase in the anti-Leu 7 positive cells, mostly natural killer cells, an important increase in anti-Leu 12 labelled T cells, i.e., human B-lymphocytes, and no differences in the OKT8 suppressor cells. Total fluorescence intensity profiles between the exposed and the unexposed group did not differ, i.e., the marker density on the cell surfaces remained unchanged. Similar changes in lymphocyte subpopulations are found in states of immunodeficiency and immunogenetic forms of aplastic anemia, a disease whose etiological relationship may be due to long-term exposure to organic solvents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00381378
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  • 5
    Electronic Resource
    Electronic Resource
    Zur Frage der Amyloidablagerung im menschlichen Hoden (1970)
    Springer
    Archives of dermatological research 239 (1970), S. 219-226 
    Details
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 26 Fällen mit generalisierter Amyloidose (primärer-, sekundärer- und Altersamyloidose) wurde anhand der fluorescenz- und polarisations-mikroskopischen Untersuchungsmethode der Frage nachgegangen, in welchem Ausmaß der Hoden Amyloidablagerungen aufweisen kann und welche Bindegewebselemente dabei als Leitstrukturen beteiligt sind. Als wesentlicher Befund ist hervorzuheben, daß bei massivem Amyloidbefall in anderen Organen der Hoden im allgemeinen nur diskrete Amyloidablagerungen aufweist und demnach dafür keinen Prädilektionsort darstellt. Bei den 6 Fällen mit primärer Amyloidose (2 Fälle Mycosis fungoides und 4 Fälle progressive Sklerodermie) fanden sich jeweils nur in einem Fall amyloide Ablagerungen. Die 7 Fälle mit sekundärer Amyloidose (4 Fälle Lymphogranulomatose und 3 Fälle Bronchialcarcinom) wiesen in 2 Fällen mit Lymphogranulomatose und in 1 Fall mit Bronchialcarcinom Amyloidablagerungen auf. Bei 13 Fällen mit Altersamyloidose wurde nur in 2 Fällen Amyloid nachgewiesen.
    Notes: Summary In 26 cases with generalized amyloidosis (primary-, secondary- and senile amyloidosis) we investigated by means of the fluorescent and polarising microscope, to what extent the testicle can show depositions of amyloid and what elements of connective tissue are involved as a precipitating system. The results clearly point ont that in cases of severe amyloidosis of other organs the testicles in general show only discreet depositions of amyloid. Therefore they cannot be regarded as a site of predilection for amyloidosis. Among 6 cases with primary amyloidosis (2 cases of mycosis fungoides and 4 cases of scleroderma) only in 1 case with mycosis fungoides and 1 case with scleroderma depositions of amyloid were found. Among 7 cases with secondary amyloidosis (4 cases of lymphogranulomatosis and 3 cases of bronchial carcinoma) 2 cases with lymphogranulomatosis and 1 case with bronchial carcinoma presented depositions of amyloid. In 13 cases with senile amyloidosis only in 2 cases amyloid was detected.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00520336
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