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  • 1
    Electronic Resource
    Electronic Resource
    An Investigation of the Diagnostic Value of Bilateral Femoral Neck Bone Mineral Density Measurements (2000)
    Springer
    Osteoporosis international 11 (2000), S. 675-679 
    Details
    ISSN: 1433-2965
    Keywords: Key words: Bone densitometry – Bone mineral density – Dual-energy X-ray absorptiometry (DXA) – Osteoporosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: This paper describes a study to assess the clinical value of bilateral femoral neck bone mineral density (BMD) measurements. Although a range of factors will determine clinical decisions, the classification of the site with the lowest T-score is likely to have significant bearing on the management of a patient. While it is common practice to measure BMD at the lumbar spine and a single neck of femur, knowledge of the BMD of the second femur may also be of diagnostic value. Using dual-energy X-ray absorptiometry, BMD of the lumbar spine and right and left femoral neck was measured in a group of 2372 white, Caucasian women (mean age ± SD, 56.6 ±13.9 years) routinely referred for bone densitometry. Analysis of the measurements showed a significant (p= 0.02) but small difference between the mean BMD of the right (0.840 ± 0.152 g/cm2) and left (0.837 ± 0.150 g/cm2) femoral neck. Further investigation of femur scans revealed 79 (3.3%) patients in whom one side was osteoporotic while the other side and spine were normal or osteopenic using the World Health Organization diagnostic criteria in combination with manufacturer”s reference data. Patients in whom the femoral neck BMD measurements differed by less than the precision error of the system were then excluded. This left only 51 (2.2%) patients, that is 29 (1.2%) for right femur and spine scan and 22 (0.9%) for left femur and spine scan, in whom knowledge of both femoral neck BMD measurements could have altered the classification of the lowest site assessed to osteoporotic. These data suggest that there is only a small benefit from performing bilateral femoral neck BMD measurements. Since BMD measurements are only one of a range of factors considered as part of a patient”s management, it is suggested that the extra time, cost and radiation dose associated with measurement of the second femur may not be justified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980070065
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Determinants of Bone Loss in Elderly Men and Women: A Prospective Population-Based Study (1999)
    Springer
    Osteoporosis international 10 (1999), S. 384-391 
    Details
    ISSN: 1433-2965
    Keywords: Key words:Anthropometry – Bone loss – Epidemiology – Lifestyle – Osteoporosis – Prospective
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: While several studies have described the rate and pattern of involutional bone loss in women, far less information is available for men. Furthermore, the roles of lifestyle and body build in determining bone loss rate in both sexes have been largely extrapolated from cross-sectional studies. We addressed this issue in a population-based longitudinal study which sought to ascertain rates of bone loss at the femoral neck and lumbar spine in a cohort of men and women aged 60–75 years at baseline, and to relate this loss to anthropometric and lifestyle variables. We additionally investigated the capacity of biochemical markers of bone turnover to predict bone loss rates in these subjects. Women lost bone at all sites; this ranged from 0.20%/year at the lumbar spine to 1.43%/year at the femoral trochanteric region. By contrast, men lost only 0.20%/year at the trochanteric region, and gained at the lumbar spine (0.33%/year) and at Ward’s triangle (0.27%/year) over the 4-year period. Anthropometric measurements were associated with bone loss in both sexes; lower baseline body mass index (BMI) and a greater rate of loss of adiposity over the follow-up period were both associated with greater bone loss at all proximal femoral sites. These attained statistical significance after Bonferroni correction at the total proximal femur among both men (r= 0.29), p〈0.01) and women (r= 0.31, p〈0.05). Lifestyle factors associated with lower rates of bone loss (after adjustment for BMI) included alcohol consumption at the femoral neck among women (p= 0.007) and physical activity at the lumbar spine among men (p = 0.05). Serum parathyroid hormone, 25-hydroxyvitamin D and biochemical markers of bone turnover did not predict bone loss after adjustment for adiposity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001980050244
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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