ISSN:
1432-0738
Keywords:
Zinc
;
Mice
;
Intraperitoneal administration
;
Zinc antidotes
;
EDTA
;
DTPA
;
CDTA
;
d-penicilamine
;
DMPS
;
DMSA
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Sixteen chelating agents were examined to determine their relative efficacy as antidotes in acute zinc acetate intoxication in mice after i.p. administration. For a i. p. dose of 0.49 mmol/kg (LD50) of zinc acetate, the i. p. administration of chelating agents at a 2∶1 and 5∶1 mole ratio resulted in a significant antidotal action for EDTA, DTPA, CDTA, d-penicillamine (d-PA), DMPS and DMSA. EGTA, l-cysteine, triethylentetraamine (TTHA), N-acetylcysteine (NAC), 4,5-dihydroxi-1,3-benzenedisulfonic acid (Tiron), sodium salicylate, glutathione, sodium diethyldithiocarbamate (DDC), 6-mercaptopurine and N-acetyl-d, l-penicillamine (NAPA) were not effective for acute zinc acetate poisoning. The therapeutic indices and therapeutic effectiveness of the most effective chelators were, respectively: EDTA (5.0, 7.0), DTPA (7.3, 13.7), CDTA (8.6, 6.3), d-PA (4.6, 1.9), DMPS (1.3, 1.0), DMSA (3.2, 5.4). DTPA, CDTA, and EDTA appear to be the most effective agents of those tested in offsetting acute zinc intoxication in mice.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00364857
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