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  • 1
    ISSN: 1432-0428
    Keywords: Type 2 diabetes ; very low-density lipoproteins ; dietary treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To evaluate possible influences of dietary intervention on the composition of very low-density lipoproteins (VLDL), ten subjects with Type 2 (non-insulin dependent) diabetes mellitus received a hypocaloric regimen. Fifteen healthy subjects served as controls. Ultracentrifuged VLDL were analysed as cholesterol, triglycerides, apolipoprotein B (apo B), and the soluble apolipoproteins C and E (polyacrylamide gel electrophoresis in urea and densitometry) before the study, after 2 weeks and then after 3 months. Compared with the control subjects, the content of cholesterol and apo E in the VLDL was elevated in the diabetic subjects, while the area ratio of apo C-II to apo C-III1 was lowered. After diet the reduction in VLDL was accompanied by compositional changes: a decrease of the cholesterol/triglyceride ratio and of the apo E/apo C area ratio. The apo C-II/apo C-III1 area ratio remained unaffected. We conclude that one beneficial effect of therapeutic intervention in diabetes may lie in lowering the level of possibly atherogenic VLDL-components.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1173
    Keywords: Schlüsselwörter: Kongenitale Poikilodermie – Thomson-Syndrom – Hyperkeratosen – Malignität – Myopathie ; Key words: Poikiloderma congenitale – Thomson syndrome – Hyperkeratoses – Malignancy – Myopathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary. This report deals with a 15-year-old girl suffering from the verrucous type of Thomson's syndrome. Initial poikilodermatous skin changes developed on both cheeks at the age of 3 months. Subsequently, rapid generalization of typical skin findings was observed. The clinical heterogenity of this syndrome is discussed with reference to the existing literature and the present case. Up to now, very few comparable cases of associated neurological symptoms have been described.
    Notes: Zusammenfassung. Wir berichten über den Fall einer 15jährigen Patientin vom Typus verrucosus des Thomson-Syndroms. Initiale poikilodermatische Hautveränderungen an den Wangenpartien manifestierten sich im 3. Lebensmonat. Nachfolgend kam es zur schnellen Progression der typischen Hautveränderungen auf das gesamte Integument. Anhand dieses Falles wird unter gleichzeitiger Literaturberücksichtigung die klinische Heterogenität dieses Krankheitsbildes illustriert. Über assoziierte neurologische Symptome, wie in unserer Kasuistik, ist bislang nur außerordentlich selten berichtet worden.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 131 (1994), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We report a patient with Niemann-Pick disease who developed papular lesions on the face. These showed ultrastructural findings typical of this disorder. Specific skin lesions such as these are an extremely rare manifestation of Niemann-Pick disease.
    Type of Medium: Electronic Resource
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