Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 58 (1980), S. 797-809 
    ISSN: 1432-1440
    Keywords: Gammaglobulines ; Gammaglobulin modifications ; Gammaglobulin efficacy ; Hyperimmunoglobulines ; Gammaglobuline ; Gammaglobulin-modifikationen ; Gammaglobulinwirksamkeit ; Hyperimmunglobuline
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die derzeit gebräuchlichen i.v. Gammaglobuline (GG) zerfallen im wesentlichen in zwei Gruppen: Gespaltene und ungespaltene Produkte. Gespaltene GG erhält man durch Pepsin- oder Plasmin-Behandlung, ungespaltene durchβ-Propiolacton-Stabilisierung, Säure-pH-4-Behandlung oder Polyäthylenglykol-Hydroxyäthylstärke-(PEG/HÄS)-Fällung. Die einzelnen Präparate unterscheiden sich in ihrer biologischen Aktivität (bestimmte Funktionen der Komplementaktivierung und Opsonisierung sind an die Fc-Struktur gebunden) sowie im Eliminationsverhalten (ungespaltene GG haben längere intra- und extravasale Halbwertszeiten). Während die Wirkung von GG in tierexperimentellen Studien gesichert erscheint, stehen für die meisten klinischen Indikationen kontrollierte Studien noch aus. Eine prospektive Studie an chirurgischen Risikopatienten ergab, daß die prophylaktische Gabe von hohen Dosen eines 7 S-GG die Häufigkeit septischer Komplikationen im post-operative Verlauf zu senken vermochte. Die Zukunft der GG-Therapie scheint in der Entwicklung eines größeren Spektrums von Hyperimmunglobulinen zu liegen.
    Notes: Summary The presently available i.v. gammaglobulines (GG) can be classified into two groups: Degraded and intact GG. Degraded GG are produced by pepsin or plasmin digestion. Intact GG are obtained byβ-propiolactone treatment, acidification at pH 4 or precipitation with polyethylenglycol-hydroxyethylstarch (PEG/HES). The various products have different characteristics with regard to their biological activity (certain functions of complement activation and opsonization are connected with the Fc structure) as well as their elimination (intact GG have longer intra-and extravasal half-life times). While their is no doubt about an effect of GG in animal experiments, little controlled studies have been done for most of the clinical indications. One controlled prospective study showed that in surgical high risk patients the frequency of septic complications can be reduced by prophylactic application of high doses of 7 S-GG. For the future, the development of a broad spectrum of hyperimmunoglobulines seems desirable.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 67 (1989), S. 203-206 
    ISSN: 1432-1440
    Keywords: Phospholipases ; Trauma ; Nonpenetrating wounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Phospholipase A serum activity was prospectively studied in 39 patients with multiple trauma. There was no correlation of phospholipase A activity with type or severity of injury. With increasing phospholipase A levels, a rise in mortality was found. A prediction of fatal outcome on an individual basis was not possible. The sensitivity for complications was 90%, whereas the predictive value of the positive test (64%) and specificity (47%) were low. When the behavior of phospholipase A and elastase release were compared, no correlation between these two parameters could be detected. Therefore, PMN leukocytes do not seem to be a major source of phospholipase A in serum.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Intensive care medicine 21 (1995), S. 784-789 
    ISSN: 1432-1238
    Keywords: Pulmonary function ; Mechanical ventilation ; Ventilators ; Transportation of patients ; Intra-hospital transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective To evaluate the impact of intra-hospital transport of artificially ventilated patients on respiratory function, and to define predictors that may allow estimation of the risk of post-transport pulmonary deterioration. Design Prospective observation study. Setting Surgical ICU, University Hospital. Patients 49 intra-hospital transports (median Apache-score before transport 21, of 28 consecutive patients (all intubated and mechanically ventilated) were studied. Interventions 32 transports were destined to the radiology department and 17 to the operating theatre. Patients were ventilated during transportation with a transport ventilator. Measurements and results The base-line condition of the patients and any changes of hemodynamic function were noted. Arterial blood gases were determined before transport as well as 0.25, 1, 6, 12, and 24 h after return of the patient to the ICU. Of the transports 41 (83.7%) resulted in a decrease of PO2/FIO2-ratio with a deterioration of more than 20% from baseline in 21 cases (42.8%). The impairment of respiratory function lasted longer than 24 h in 10 subjects (20.4%). Ventilation with positive end-expiratory pressure correlated significantly (r=−0.4) with post-transport change of PO2/FIO2-ratio, whereas initial FIO2, initial PO2/FIO2-ratio, Apache II-score, patients' age or transport time did not distinguish between patients with and without a consecutive decrease of pulmonary function. Conclusion Intra-hospital transport of ventilated critically ill patients may result in a considerable and long-standing deterioration of respiratory function. Patients ventilated with positive end-expiratory pressure are at an increased risk and the indication for procedures away from the ICU has to be weighed carefully in these subjects.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Research in experimental medicine 167 (1976), S. 255-266 
    ISSN: 1433-8580
    Keywords: Xenotransplantation ; tissue typing ; antilymphocyte globulin ; Xenotransplantation ; DL-A-Typisierung und MLC ; Antilymphozytenglobulin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das zoologisch als xenogen bezeichnete System Wolf-Hund ist nach immunologischen Kriterien näher verwandt als DL-A-kompatible und MLC-negative unverwandte Hunde. Unbehandelte Hauttransplantate wurden nach 12,5 Tagen (Allotransplantate verwandter Hunde nach 9,1 Tagen) abgestoßen. Immunsuppression mit ALG verlängert diese Überlebenszeit erheblich auf 85,6, im Einzelfall über 200 Tage. Es liegt hier eine Spender-Empfänger-Kombination vor, deren schwache Histoinkompatibilität durch MLC und DL-A nicht zum Ausdruck kommt. Vermutlich ist sie durch andere genetische Systeme bedingt, die heute noch nicht zu bestimmen sind. Es konnte jedenfalls gezeigt werden, daß Transplantationen zwischen unterschiedlichen Spezies sogar mit besserem Erfolg als bei nicht verwandten Allotransplantaten möglich sind. Ziel der weiteren Forschung muß es sein, ein solches System auch für die menschliche Transplantation zu finden. Damit wären klinische Xenotransplantationen in größerem Ausmaß als bisher möglich.
    Notes: Summary In contrast to the zoological definition that wolf and dog belong to different species, it is shown by this study that in terms of immunology both species appear to be even closer related than DL-A compatible and MLC negative unrelated dogs. However, this close relationship is not expressed in DL-A or MLC tissue typing. Wolf skin-graft survival time in untreated dogs was 12,5, in AlG-treated dogs 85,6 days. The survival time in this system may be less dependent on DL-A or MLC histocompatibility than on other genetic systems, which are hitherto not sufficiently defined. An accidental, speciesspecific accordance in these systems may explain the obviously weak histocompatibility barrier between wolf and dog. It is concluded that in certain species-combinations xenotransplantation could be more successful than random allotransplantation. The availability of a xenogeneic species related to man similar as wolf to dog would markedly facilitate clinical xenotransplantation.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    ISSN: 1433-044X
    Keywords: Key words Polytrauma • ARDS • Prone positioning • Outcome ; Schlüsselwörter Polytrauma • Thoraxtrauma • ARDS • ; Lungenversagen • Bauchlagerung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die intermittierende Bauchlagerung (BL) gilt für Patienten mit schwerem respiratorischen Versagen als ein erfolgsversprechender Therapieansatz. Ergebnisse bzgl. des Behandlungsoutcomes liegen nicht vor. Ziel dieser Studie war es Auswirkungen der intermittierenden BL bei Patienten mit posttraumatischem Lungenversagen (PaO2/FiO2 〈 280 mmHg) nach Thoraxtrauma im Vergleich zur konventionellen Therapie zu untersuchen. Im Rahmen unserer prospektiven Polytraumastudie wurden die Daten von 136 polytraumatisierten Patienten mit einem mittleren ISS von 23,4 erfaßt und ausgewertet; 77 Patienten hatten ein schweres Thoraxtrauma (AIS L 3) von denen 47 im weiteren Verlauf ein respiratorisches Versagen entwickelten. 19 dieser Patienten wurden konventionell in Rückenlage therapiert, 28 wurden intermittierend auf dem Bauch gelagert. Bei gleichem AIS-Thorax (3,6 vs. 3,3) waren die Patienten mit BL signifikant schwerer verletzt (ISS 35,8 vs. 24,5). Trotz erhöhter Verletzungsschwere der BL-Patienten war die Beatmungsdauer (32 vs. 31 Tage) und die Behandlungsdauer (ICU: 39 vs. 36 Tage) bei den konventionell therapierten Patienten gleich hoch. Die Letalität betrug bei den BL-Patienten 0 %, bei den konventionell therapierten Patienten 26 % (5 Patienten). Während des ersten Zyklus in BL verbesserte sich der Oxygenierungsquotient (PaO2/FiO2) im Durchschnitt um 82 mmHg (26–151 mmHg). Bei Beendigung der Wechsellagerung war der Oxygenierungsquotient um 111 mmHg (22–257 mmHg) angestiegen. Der FiO2 konnte von 0,45 (0,35–1,0) auf 0,26 (0,21–0,35) reduziert werden. Neben dem positiven Effekt auf den Gasaustausch ergeben sich erstmals deutliche Hinweise, daß die intermittierende BL sich günstig auf den Behandlungsverlauf sowie das Behandlungsergebnis bei Patienten mit posttraumatischem Lungenversagen auswirkt (gleicher Outcome bei höherer Verletzungsschwere der Patienten in BL).
    Notes: Summary Intermittent prone positioning (PP) is a promising therapy of patients with severe respiratory failure. Evaluations of patient outcomes can not, to dare, be found in the literature. This study was conducted to investigate the effects of intermittent PP on patients with posttraumatic respiratory failure (PaO2/FiO2 〈 280 mmHg) in comparison with conventional therapy in suspine position. The collected data is part of our prospective polytrauma study. 136 polytraumized patients (mean ISS 23.4) were included and evaluated. 77 patients had a severe chest trauma with an AIS L 3. Of these, 47 patients developed a respiratory failure. 19 of these patients were treated conventionally in suspine position, 28 patients were intermittingly turned prone. Having similar AIS (3.6 vs. 33), the PP-patients had a significantly severer trauma (ISS 35.8 vs. 24.5). Though the injury severity of the PP-patients was much higher, the time of ventilation (32 vs. 31 d) and the ICU stay (39 vs. 36 d) was similar to the patients treated in suspine position. The mortility of PP-patients was 0 %, of suspine positioned patients 26 %. After the first PP the PaO2/FiO2 ratio increased with an average of 82 mmHg (26–151 mmHg). The FiO2 was reduced from 0.45 (0.35–1.0) to 0.26 (0.21–0.35). Beside the beneficial effect of PP on the oxygenation we have, for the first time evidence that PP improves the outcome of patients with posttraumatic respiratory failure.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 366 (1985), S. 631-631 
    ISSN: 1435-2451
    Keywords: Generalized peritonitis ; Open peritoneal cavity ; Incidence of sepsis ; Diffuse Peritonitis ; Offene Peritonitisbehandlung ; Sepsishäufigkeit
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Seit 1982 wurden bei 25 Patienten insgesamt 104 Revisionen wegen diffuser Peritonitis durchgeführt, ehe das Abdomen verschlossen wurde. Im Gegensatz zu der früher geübten Dauerlavage waren dabei die Zeichen des septischen Schocks weniger häufig zu messen, der periphere O2-Verbrauch lag nicht unterhalb der Norm, der PaO2/FiO2-Index war nur unwesentlich verringert. Der Volumenbedarf war geringer, die Gewichtszunahme weniger ausgeprägt. Wir führen die Senkung der Letalität von 40% auf 20% auf die bei offener Behandlung eher beherrschbare Sepsis zurück.
    Notes: Summary During the past 2 years, 25 patients have been treated for generalized peritonitis by leaving the peritoneal cavity open. Comparing the earlier method performed using continuous lavage with closed abdominal wall, patients with open peritoneal cavity showed a decrease in the incidence of septic shock. The O2 consumption and PaO2/FiO2 index were only slightly diminished. The quantity of volume replacement and the increase in body weight were less than in patients with postoperative lavage. We conclude that leaving the peritoneal cavity open can reduce the incidence of sepsis and therefore mortality from generalized peritonitis.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Archives of dermatological research 260 (1977), S. 201-206 
    ISSN: 1432-069X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die chemische Modifikation von Standardgammaglobulin durch enzymatische Spaltung (Pepsin) oder Stabilisierung (β-Propiolacton) beeinflußt Elimination, Fragmentierung und Organverteilung des intravenös applizierten Gammaglobulins. Untersuchungen mit radioaktiv markierten allogenen und xenogenen Gammaglobulin-Präparaten an 36 Hunden zeigten, daß das pepsingespaltene Gammaglobulin am schnellsten fragmentiert und eliminiert wurde. Dabei fand sich für die Konzentration aller Gammaglobuline in der Haut ein wesentlich langsamerer Abfall als im Blut. Die höchsten Hautkonzentrationen nach 10 Tagen fanden sich fürβ-Propiolacton-Gammaglobulin mit 6,2 ± 1,6 µg/g Haut bei einer Blutkonzentration von 7,9 ± 0,9 µg/ml.
    Notes: Summary Chemical modification of standard gammaglobulin with enzyme treatment (pepsin) or stabilization (ß-propiolactone) is able to influence elimination, fragmentation and organ distribution of intravenously administered gammaglobulins as shown in 36 dogs after i.v. application of allogenic and xenogenic gammaglobulin preparations. Pepsin-gammaglobulin was eliminated and fragmented most rapidly. Gammaglobulin concentrations of all preparations in the skin showed as slower decrease than comparable blood concentrations. The highest skin concentrations 10 days after i.v. application were found for β-propiolactone gammaglobulin with 6.2 ± 1.6 µg/g compared to a blood level of 7.9 ±0.9 µg/ml.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    ISSN: 1433-8580
    Keywords: Gammaglobulin elimination ; i.v. Gammaglobulin ; β-Propiolactone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Dog IgG was produced by fractionation procedures used for the production of clinically used i.v. gammaglobulins. Chemical modification of dog IgG was done by pepsin orβ-propiolactone treatment. The intravascular half-life ofβ-propiolactone IgG was 8.5 ± 2.1 days compared to 4.5 ± 1.6 days of pepsin treated IgG. Tissue concentrations of radioactive labelledβ-propiolactone IgG were generally higher than of pepsin digested IgG. Pepsin treated IgG was degraded to a significantly higher extent (26% of the administered radioactivity was bound to fragments smaller than 6000 MW after three days) thanβ-propiolactone IgG (9% fragments after the same interval,P 〈 0.001). It is concluded that the short intravascular half-life of pepsin IgG cannot be explained by increased extravascular filling, but is due to rapid degradation and excretion via the kidneys. There was no obvious difference in elimination and organ distribution between standard andβ-propiolactone IgG.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...