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  • 1
    ISSN: 1432-1440
    Keywords: Waldenström's macroglobulinemia ; Paraproteinemia ; Cryoglobulinemia ; Skin ulcers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 71-year-old man presented with epistaxis and large ulcers on arms and legs. A monoclonal IgM-kappa gammopathy and high levels of cryoglobulins were found. Histology of the affected skin showed deposits of paraprotein in the small vessels, causing luminal obstruction. This in turn caused ischemic skin lesions, which were successfully treated with cortisone (fluocortolone 100 mg/day every second day) and cyclophosphamide (100 mg/day).
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Histopathology 21 (1992), S. 0 
    ISSN: 1365-2559
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Four mucinous sweat gland carcinomas were examined for the distribution of cytokeratin (CK) polypeptides using immunohistochemical techniques on paraffin-embedded sections. All the tumour specimens reacted with monoclonal antibodies to CK 7, CK 8, CK 18 and CK 19. Antibodies to CK 1, CK 1/2/10/14, CK 1/5/10/11, CK 13, CK 14 and CK 20 did not stain any of the carcinomas. The results add additional support to the notion that mucinous sweat gland carcinoma represents a tumour histogenetically related to the eccrine secretory coil. Furthermore, the absence of CK 20 might significantly contribute to the differentiation of this tumour from cutaneous metastases from gastrointestinal carcinomas.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 124 (1991), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The immunophenotype and genotype of atypical cells in skin and lymph node infiltrates were investigated in a patient with lymphomatoid papulosis (LyP) complicated by anaplastic large-cell lymphoma of the lymph nodes. The large atypical cells in both skin and lymph nodes displayed an almost identical immunophenotype, i.e. CD30+ and CD25+ .Southern blot analysis for T-cell receptor β-chain gene rearrangement revealed an identical gene configuration in DNA extracted from skin and lymph node. Our results strongly support the hypothesis that clonal populations of T cells arising in cutaneous LyP lesions may undergo malignant transformation, spread into regional lymph nodes, and give rise to secondary malignant lymphomas, such as anaplastic large-cell lymphoma.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 130 (1994), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Although myoepithelial cells are detectable in many benign sweat gland tumours, little is known about their role in sweat gland carcinomas. To specifically demonstrate myoepithelial cells, paraffin sections from 46 sweat gland carcinomas were stained, using a standard avidin-biotin-peroxidase complex method, with the monoclonal α-smooth muscle actin antibody 1A4. Myoepithelial cells were not found in adenoid cystic eccrine carcinoma (n=2), malignant nodular hidradenoma (n=2), porocarcinoma (n=4), extramammary Paget's disease (n= 12), sclerosing sweat duct carcinoma (n=4) or in adenosquamous mucoepidermoid carcinoma (n=l). In contrast, myoepithelial cells were demonstrated in two of eight apocrine adenocarcinomas, one of six mucinous eccrine carcinomas and two of seven eccrine adenocarcinomas. In all these tumours myoepithelial differentiation was found in peripheral cells of solid tumour islands, or in basal cells of tubular structures. However, in most areas of the tumours, myoepithelial layers were discontinuous. Cells in the centre of solid tumour nodules, and luminal cells of tubular structures, were negative for α-smooth muscle actin. In analogy to breast tumours, in which malignancy and invasiveness correlate with scattered or absent myoepithelial cells, we suggest that disrupted myoepithelial layers in sweat gland carcinomas may be interpreted as a loss of the invasion barrier.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    British journal of dermatology 126 (1992), S. 0 
    ISSN: 1365-2133
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: A 56-year-old man presented with a 30-year history of a slowly enlarging lesion on the sole of his right foot. A biopsy showed an anastomosing network of small cuboidal cells with the formation of occasional sweat ductal lumina and a marked fibrovascular stroma. The histological findings were interpreted as consistent with the diagnosis of an eccrine syringofibroadenoma. Using immunohistochemistry all the tumour cells were positively stained by the pan-cytokeratin antibody Lu-5 and an antibody to the cytokeratins 1/5/10/11. In addition the luminal ductal cells expressed cytokeratin 19 and CEA. Tumour cells were negative for cytokeratins 1, 7, 8, 13 and 18 and did not express vimentin and GCDFP-15. The results indicate that the eccrine syringofibroadenoma is differentiated towards the dermal eccrine duct.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2307
    Keywords: Anaplastic carcinoma of the thyroid ; Haemangioendothelioma ; Immunohistology ; Coexpression of epithelial and vascular antigens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sixteen cases of anaplastic carcinoma (ACA) and 4 cases of malignant haemangioendothelioma (HAE) of the thyroid were studied by light microscopy and immunohistochemistry. Seven cases of ACA and 3 cases of HAE were characterized by coexpression of immunohistological features of epithelial and vascular endothelial cells. Expression of vimentin was common to all tumours investigated. The present study provides evidence that ACA and HAE are partially closely related tumours showing alternating differentiation. This speaks in favour of a common neoplastic cell with the potential for epithelial and vascular endothelial differentiation.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of comparative physiology 14 (1931), S. 93-120 
    ISSN: 1432-1351
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Zusammenfassung 1. Die Verdünnungsreihe von MgSO4 zeigte — zwischen kh 5 und 20 geprüft — keinerlei spezifische Einflüsse auf die Teilungsrate von Paramaecium. 2. AgNO3 ließ in den ersten Versuchstagen unmittelbar jenseits der tödlichen und der hemmenden Konzentrationen vorübergehend stimulierende Eigenschaften erkennen, mit einer Wirkungsgrenze bei ungefähr kh 12. 3. In drei Versuchsserien mit Chininum hydrochl. fanden wir bestätigt, daß in der Verdünnungsreihe jenseits der hemmenden Konzentrationen solche folgen, welche die Teilungsrate von Paramaecium erhöhen (mit einem Maximum in kh 8,5), daß anschließend eine langsame Abnahme der Wirkungsintensität bis ungefähr zur Indifferenz zu beobachten ist, und hierauf wieder eine Zunahme bis zu einem zweiten Gipfel in kh 18, jenseits dessen sich unweit (bei kh 20) die äußerste Empfindlichkeitsgrenze befindet. Die Stimulation erreichte in ihren beiden Gipfeln ungefähr dasselbe Ausmaß; die Teilungsrate war in den betreffenden Konzentrationen jeweils um etwa 50% gegen die Kontrollwerte erhöht, doch wurde in einer Versuchsperiode mit besonders gutem allgemeinen Kulturerfolg beobachtet, daß die stimulative Überhöhung der Teilungsrate relativ und absolut abnahm, je mehr sich die Kontrollwerte einem (fiktiven) Maximalwert näherten (Übereinstimmung mit dem „Mitscherlichschen Ertragsgesetz“). In einer fast 6 Wochen hindurch fortgesetzten Züchtungsserie, bei welcher ein Verderben der Chininlösung ausgeschlossen wurde, haben sich die spezifischen Wirkungen der Verdünnungsreihe während der gesamten Versuchsdauer als konstant erwiesen.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Annals of hematology 53 (1986), S. 11-19 
    ISSN: 1432-0584
    Keywords: Bone marrow plasmocytosis ; Monoclonal plasma cells ; Polyclonal plasma cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Bone-marrow biopsies and smears from 59 patients with reactive plas-mocytosis (22), multiple myeloma (24), solitary plasmocytoma (3) and monoclonal gammopathy of undetermined significance (MGUS) (10) were eamined. To demonstrate cytoplasmic immunoglobulin the immunoperoxidase method was applied and evaluated quantitatively. Immunohistology yielded different ranges in κ/λ ratio for reactive plasmocytosis (0.4–3.5), multiple myeloma (≤ 0.1 and ≥ 11.2) and MGUS (0.2–3.0). As a result this method seems to be helpful in characterizing a plasmocytosis and distinguishing overt myeloma from monoclonal gammopathy of undetermined significance and reactive plasmocytosis. A differentiation of monoclonal gammopathy of undetermined significance from reactive plasmocytosis is not possible histologically and immunohistologically.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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