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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 59 (1981), S. 571-573 
    ISSN: 1432-1440
    Keywords: ECHO virus type 9, strain A. Barty ; viral infection ; Human granulocyte-function ; chemotaxis ; Host defense mechanismus ; ECHO Virus, Typ 9, Stamm A.Barty ; Virusinfektion ; Granulozytenfunktion ; Chemotaxis ; Resistenz
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch die Vorinkubation (37°C, 60 min) menschlicher Blutgranulozyten mit unterschiedlich hohen Dosen infektiösen ECHO-Virus, Typ 9, Stamm A. Barty kommt es in der Boyden-Kammer zu einer Virusdosis-abhängigen Hemmung der chemotaktischen Reaktionsfähigkeit der Granulozyten auf chemotaktisch aktive Substrate (F-Met-Leu-Phen; Zymosan aktiviertes Serum). Andere Zellfunktionen — Phagozytose, oxydativer Zellstoffwechsel, intrazelluläres Abtöten von lebenden Staphylokokken — werden nicht beeinflußt.
    Notes: Summary Preincubation (37°C, 60 min) of human neutrophilic granulocytes with various concentrations of infectious ECHO virus, type 9, strain A. Barty resulted in virus-dose dependent inhibition of neutrophil chemotactic reactivity (Boyden-chamber assay) to chemoattractants (F-Met-Leu-Phen: zymosan-activated human serum). Other cellular functions-phagocytosis, increase of oxidative cell metabolism, intracellular killing of live staphylococci — remained intact. This selective inhibition of human neutrophilic chemotaxis was not due to viral induced cytotoxicity or competitive inhibition of chemotactic cell surface receptors.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract As enteroviruses are mainly transmitted by the fecal-oral route, this study was initiated to investigate the nature of the binding of enteroviruses to human skin. Using poliovirus 1, Mahoney, we investigated the overall effectiveness of soap and water hand-washing of 1 and 5 min duration. The virus-skin interaction was studied by kinetic analysis of repeated serial washings. The following results were obtained: (1) Soap and water washing for 5 min reduced the number of infective particles on hands by 2–4 logs of ten. (2) Poliovirus binding to skin was essentially reversible. (3) Removal of virus followed a triexponential decline curve, suggesting loose, intermediate, and strong binding. (4) Washing agents more effective than soap were sand, aluminum hydroxide powder, and buffer alone, suggesting that friction was more important than emulsification. The results demonstrate the tenacity of poliovirus on skin, and offer a rationale for the epidemiology of enteroviruses on experimental grounds. From a practical point of view these results stress the need for an effective chemical hand disinfectant, particularly in hospitals.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The case of a 4-month-old girl is described who developed a paralytic polio-like syndrome 3 weeks after oral polio vaccination (OPV). All three poliovirus types could be isolated (9 days after onset of disease polio type 2, and 33 days after onset of disease types 1 and 3, respectively). In order to classify these isolates as Sabin (vaccine)-like (SL) or non-Sabin-like (non-SL), several markers were tested in three laboratories [intratypic serodifferentiation, reproductive capacity at supraoptimal temperature (RTC), A1(OH)3 gel elution assay, and oligonucleotide mapping]. The results of the marker determinations were not uniform, but — summarizing all data — it seems plausible to associate the disease with the OPV. The significance of marker determinations in proving a vaccine-induced poliomyelitis is discussed in the light of this clinical case. Some comments are made on poliovirus vaccination policy in developed countries.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Medical microbiology and immunology 172 (1983), S. 181-189 
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Four different tests for detection of rubella-specific IgM antibodies were compared: two Ig separation methods (centrifugation and chromatography) with subsequent haemagglutination inhibition test and two commercially available ELISA tests. The 114 sera tested had been sent to the diagnostic laboratory, mostly with insufficient clinical histories. Agreement between the centrifugation method and one of the ELISA tests was good (2 divergent results with 107 sera tested), while the other ELISA test yielded more positive (partly perhaps non-specific) results. The chromatographic method did not separate the Ig classes as reliably as the centrifugation method, but because of its simplicity it may be useful, if adequate test controls are performed. The divergent results are discussed. It is postulated that in cases with pending induced abortion, two independent tests should be performed.
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The performances of a vertical and a swinging bucket rotor in the diagnosis of rubella-specific IgM were compared using two sets of predominantly low titre rubella IgM positive sera. Applying a number of subtle criteria, the vertical rotor was shown to separate IgM and IgG less well than the swinging bucket rotor. If the vertical rotor was loaded with pretreated sera with IgG content decreased severalfold, its performance was similar to that of the swinging bucket rotor with native serum. The findings are discussed from the aspect of the main indication of rubella IgM testing, and it was concluded that for the majority of cases the vertical rotor would not present an alternative to the swinging bucket rotor.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1076
    Keywords: Coxsackie virus B2 ; Neonatal infection ; Family outbreak ; Diagnostic measures
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Two cases of neonatal coxsackie virus B2 infection are described. One infant presented with meningitis and enteritis, the other with rhinitis, meningoencephalitis, and enteritis. Both infants made good recoveries. The virus infection could also be demonstrated in all nonimmune family members, most of whom gave a history of recent mild febrile disease (pharyngitis, diarrhea). Enterovirus infections may be suspected in cases of neonatal meningitis or myocarditis associated with gastrointestinal signs, especially 1. when it is during the hot season July-October, 2. when there has been febrile illness in other family members recently. For an effective and rapid isolation of the agent, rectal swabs or stool specimens not only from the patient, but also from household contactss should be sent to the virus laboratory on several consecutive days. Meningitic infection may be proved by anearly c.s.f. sample. For serodiagnosis a first blood specimen should be drawn as soon as possible, a second one some days later. The importance of rapid virological diagnosis and of stringent hygienic measures to prevent spread of the infection is stressed.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 140 (1983), S. 293-294 
    ISSN: 1432-1076
    Keywords: Juvenile diabetes ; Coxsackie serology ; IgM antibodies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In a search for Coxsackie B virus-induced, insulin-dependent diabetes mellitus (IDDM) we examined sera from 166 selected patients (age 1–17 years) with recent onset of IDDM for specific neutralizing antibodies. All 166 patients investigated had a clinical history of recent infectious illness. Eighty per cent of the patients had antibodies against at least one Coxsackie B virus type. But even among the children studied with antibody titers higher than 256 only in about 44% could a recent Coxsackie B virus infection be serologically demonstrated by determining specific neutralizing IgM antibodies. This result again strengthens the notion that IDDM includes several different etiologic groups, among others possibly Coxsackie B virus infections.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 130 (1965), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Pharmacology 6 (1966), S. 231-250 
    ISSN: 0362-1642
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A survey of the antiviral activity of forty-one derivatives of 2-(α-hydroxybenzyl)-benzimidazole (HBB) pinpoints the structural features of the HBB molecule essential for selective inhibition of viral ...
    Type of Medium: Electronic Resource
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