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  • 1
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 206 (1965), S. 841-842 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Wilson and Wiseman2 described a technique which permitted the direct examination of the movement of substances across the intestinal membrane by in vitro methods. This technique has been adapted to provide information concerning the influence of alginic acid on the absorption of calcium and ...
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1432-2072
    Keywords: Key words Naloxone ; Alcohol ; Selectively bred rat lines ; P rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Objective: This study examined whether repeated daily treatment with naloxone prevents expression of a genetic predisposition toward high alcohol drinking in rats selectively bred for alcohol preference (P line). Methods: In phase 1, alcohol-naive male rats were given food and water ad libitum and were pretreated with naloxone (2.5, 5.0, or 10.0 mg/kg, IP) or saline prior to scheduled access to alcohol (2 h/day) for 30 days. In phase 2, naloxone treatment was suspended for 30 days while rats continued to receive food and water ad libitum and scheduled access to alcohol. In phase 3, alcohol access was suspended for 14 days while rats continued to receive food and water ad libitum. In phase 4, daily pretreatment with naloxone or saline, followed by scheduled access to alcohol, was reinstated for an additional 30 days. Results: Naloxone dose-dependently retarded acquisition of alcohol drinking. Following discontinuation of naloxone treatment, alcohol intake increased to levels comparable to those seen in the saline-treated group. Naloxone dose-dependently suppressed reinstatement of alcohol drinking (relapse) after a period of imposed abstinence. Conclusions: The results suggest that naloxone retards the acquisition of alcohol drinking and suppresses reinstatement of alcohol drinking in rats genetically predisposed toward high alcohol intake.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    International Journal for Numerical Methods in Fluids 28 (1998), S. 1139-1158 
    ISSN: 0271-2091
    Keywords: non-linear Reynolds stresses ; k-ε turbulence model ; higher-order convective scheme ; pressure correction ; direct sparse matrix solver ; incompressible duct flows ; Engineering ; Numerical Methods and Modeling
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A non-linear modelling of the Reynolds stresses has been incorporated into a Navier-Stokes solver for complex three-dimensional geometries. A k-ε model, adopting a modelling of the turbulent transport which is not based on the eddy viscosity, has been written in generalised co-ordinates and solved with a finite volume approach, using both a GMRES solver and a direct solver for the solution of the linear systems of equations. An additional term, quadratic in the main strain rate, has been introduced into the modelling of the Reynolds stresses to the basic Boussinesq's form; the corresponding constant has been evaluated through comparison with the experimental data. The computational procedure is implemented for the flow analysis in a 90° square section bend and the obtained results show that with the non-linear modelling a much better agreement with the measured data is obtained, both for the velocity and the pressure. The importance of the convection scheme is also discussed, showing how the effect of the non-linear correction added to the Reynolds stresses is effectively hidden by the additional numerical diffusion introduced by a low-order convection scheme as the first-order upwind scheme, thus making the use of higher order schemes necessary. © 1998 John Wiley & Sons, Ltd.
    Additional Material: 14 Ill.
    Type of Medium: Electronic Resource
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