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  • 1
    Electronic Resource
    Electronic Resource
    Insulin resistance and abnormal albumin excretion in non-diabetic first-degree relatives of patients with NIDDM (1995)
    Springer
    Diabetologia 38 (1995), S. 363-369 
    Details
    ISSN: 1432-0428
    Keywords: Key words Microalbuminuria ; insulin resistance syndrome ; insulin sensitivity ; euglycaemic hyperinsulinaemic clamp.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microalbuminuria has recently been associated with insulin resistance in both insulin-dependent and non-insulin-dependent (NIDDM) diabetes mellitus. To establish whether microalbuminuria in non-diabetic subjects as well is associated with insulin resistance and associated abnormalities in glucose and lipid metabolism, oral glucose tolerance tests were performed with measurement of urinary albumin excretion rate, lipids and lipoproteins in 582 male non-diabetic first-degree relatives of patients with NIDDM. In addition, insulin sensitivity was assessed in 20 of these subjects with the euglycaemic hyperinsulinaemic clamp technique. Abnormal albumin excretion rate (AER), defined as AER 15–200 μg/min, was associated with higher systolic blood pressure (p 〈 0.05), higher fasting glucose values (p 〈 0.05), lower HDL-cholesterol (p 〈 0.05) and lower apolipoprotein A-I (p 〈 0.05) concentrations than observed in subjects with normal AER. The rate of glucose metabolism was lower in subjects with abnormal compared to subjects with normal albumin excretion rate (38.0 ± 2.8 vs 47.3 ± 2.4 μmol · kg lean body mass–1· min–1; p = 0.028). This difference was almost completely accounted for by a reduction in non-oxidative glucose metabolism (17.7 ± 1.9 vs 27.4 ± 2.7 μmol · kg lean body mass–1· min–1; p = 0.010), which correlated inversely with the AER (r = –0.543; p = 0.013). These results suggest that in non-diabetic individuals genetically predisposed to NIDDM, abnormal AER is associated with insulin resistance and abnormalities in glucose and lipid metabolism. [Diabetologia (1995) 38: 363 –369]
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400643
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Insulin resistance and abnormal albumin excretion in non-diabetic first-degree relatives of patients with NIDDM (1995)
    Springer
    Diabetologia 38 (1995), S. 363-369 
    Details
    ISSN: 1432-0428
    Keywords: Microalbuminuria ; insulin resistance syndrome ; insulin sensitivity ; euglycaemic hyperinsulinaemic clamp
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Microalbuminuria has recently been associated with insulin resistance in both insulin-dependent and non-insulin-dependent (NIDDM) diabetes mellitus. To establish whether microalbuminuria in non-diabetic subjects as well is associated with insulin resistance and associated abnormalities in glucose and lipid metabolism, oral glucose tolerance tests were performed with measurement of urinary albumin excretion rate, lipids and lipoproteins in 582 male non-diabetic first-degree relatives of patients with NIDDM. In addition, insulin sensitivity was assessed in 20 of these subjects with the euglycaemic hyperinsulinaemic clamp technique. Abnormal albumin excretion rate (AER), defined as AER 15–200 Μg/min, was associated with higher systolic blood pressure (p〈0.05), higher fasting glucose values (p〈0.05), lower HDL-cholesterol (p〈0.05) and lower apolipoprotein A-I (p〈0.05) concentrations than observed in subjects with normal AER. The rate of glucose metabolism was lower in subjects with abnormal compared to subjects with normal albumin excretion rate (38.0±2.8 vs 47.3±2.4 Μmol·kg lean body mass−1. min−1; p=0.028). This difference was almost completely accounted for by a reduction in non-oxidative glucose metabolism (17.7±1.9 vs 27.4±2.7 Μmol·kg lean body mass−1. min−1; p = 0.010), which correlated inversely with the AER (r=−0.543; p=0.013). These results suggest that in non-diabetic individuals genetically predisposed to NIDDM, abnormal AER is associated with insulin resistance and abnormalities in glucose and lipid metabolism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00400643
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    An experimental study of a two-dimensional plane turbulent wall jet (1998)
    Springer
    Experiments in fluids 25 (1998), S. 50-60 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract  Laser-Doppler measurements were conducted in a plane turbulent wall jet at a Reynolds number based on inlet velocity, Re 0, of 9600. The initial development as well as the fully developed flow was studied. Special attention was given to the near-wall region, including the use of small measuring volumes and the application of specific near-wall data corrections, so that wall shear stresses were determined directly from the mean velocity gradient at the wall using only data below y +=4. It was possible to resolve the inner peak in the streamwise turbulence intensity as well as the inner (negative) peak in the shear stress. Limiting values of (u′)+ and uv + were determined. Turbulence data from the outer region of the flow were compared to earlier hot wire measurements and large differences in the normal turbulence intensity and the shear stress were found. These differences can be attributed to high turbulence intensity effects on the hot-wires.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003480050207
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    An investigation of the spatial resolution requirements for two-point correlation measurements using LDV (1995)
    Springer
    Experiments in fluids 18 (1995), S. 393-396 
    Details
    ISSN: 1432-1114
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract The spatial resolution requirements for accurate two-point correlation measurements at small separations are investigated. Practical guidelines in terms of characteristic measuring volume sizes and estimated Kolmogorov length scales are given. Sample measurements of two-point one-component longitudinal correlations on the centerline of a turbulent jet are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00211398
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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