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  • 1
    Electronic Resource
    Electronic Resource
    Die “bio-logische” Stabilisierung der subtrochantären Femurfraktur mit einer Kondylenplatte (1999)
    Springer
    Operative Orthopädie und Traumatologie 11 (1999), S. 296-306 
    Details
    ISSN: 1439-0981
    Keywords: Schlüsselwörter Subtrochantäre Femurfraktur ; Biologische Osteosynthese ; Kondylenplatte ; Key words Subtrochanteric femur fracture ; Biological osteosynthesis ; Condylar blade plate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Objectives Stabilization of subtrochanteric fractures through indirect reduction to avoid significant devascularisation of the fragments. Balanced proximal and distal fixation with condylar blade plate. Indications Comminuted closed or open subtrochanteric femur fractures, especially with extension to the base of the femoral neck. Contraindications None; in multiple injured patients with life-threatening injuries. Surgical Technique Stabilization with condylar blade plate. Capsulotomy to control the correct positioning of the blade insertion before reduction. Reduction with the help of the side-plate, aiming for length and rotation, but not for antomic reduction of fragments. Tension of the side-plate with tensioning device, if applicable. Postoperative Care Early mobilization with partial weight bearing, if possible starting on the second postoperative day. Results From 1992 to 1995, 25 patients with subtrochanteric fractures (Type A: n = 10; Type B: n = 8; Type C: n = 7 [according to AO classification]; 4 open fractures) were treated with condylar blade plate within 48 hours after injury. Mean operation time 1.9 hours (range, 0.75 to 3.54 hours), intraoperative blood loss 1300 ml (range, 500 to 3700 ml). Normal fracture healing: 24/25. Delayed union: 1/25 due to infection of an open fracture (Gustilo IIIB); after 3 debridements and after re-osteosynthesis with a waved condylar blade plate consolidation of the fracture. Malunion: 3/25, but intertrochanteric correction of varus and rotational malalignment was only needed in 1 patient. Removal of condylar blade plate in 2 patients because of chronic irritation of the greater trochanter.
    Notes: Zusammenfassung Operationsziel Indirekte Reposition von subtrochantären Frakturen über die Ligamentotaxis ohne chirurgische Traumatisierung der Frakturzone (keine devaskularisierten Fragmente!) und übungsstabile Osteosynthese mit einer Kondylenplatte. Indikationen Geschlossene und offene subtrochantäre Trümmerfrakturen des Femurs, insbesondere bei Beteiligung der Schenkelhalsbasis. Kontraindikationen Keine, außer bei polytraumatisierten Patienten mit lebensbedrohlichen Verletzungen. Operationstechnik Osteosynthese mit einer Kondylenplatte. Kapsulotomie, um die korrekte Position der Klinge zu prüfen. Reposition der Fraktur an den Schaft der Kondylenplatte unter Kontrolle von Länge, Rotation und Achse, aber ohne anatomische Reposition der einzelnen Fragmente. Kompression der Fraktur, falls möglich, mit dem Spanngerät. Weiterbehandlung Frühe funktionelle Nachbehandlung mit 15 kg Teilbelastung ab zweitem postoperativen Tag. Ergebnisse: Von 1992 bis 1995 wurden 25 Patienten mit subtrochantärer Femurfraktur (Typ A: n = 10; Typ B. n = 8; Typ C: n = 7 [nach AO-Klassifikation]; vier offene Frakturen) mit Kondylenplatte behandelt. Operationszeit: im Mittel 1,9 Stunden; intraoperativer Blutverlust: durchschnittlich 1300 ml. Normale Frakturheilung: 24/25 Patienten. Komplikationen: Infektpseudarthrose: n = 1. Konsolidation der Fraktur nach mehrfachen Débridements und Reosteosynthese mit Wellenplatte. Achsenfehlstellungen: n = 3 (Varus: n = 2; Verkürzung. n = 1; intertrochantäre Korrekturosteotomie: n = 1). Entfernung der Platte wegen chronischer Trochanterirritation: n = 2.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s000640050013
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Therapeutical Strategies and Outcome of Polytraumatized Patients with Pelvic Injuries A Six-Year Experience (2000)
    Springer
    European journal of trauma 26 (2000), S. 278-286 
    Details
    ISSN: 1615-3146
    Keywords: Key Words Multiple injury ; Pelvic injury ; Hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The combination of multiple injuries and pelvic ring disruption often represents a devastating injury pattern. This study evaluates therapeutical strategies and the outcome of 174 severely traumatized patients with pelvic ring injury (ISS: 32.1±11.1 patients) over a 6-year period. Patients were divided into 3 groups according to their hemodynamic status at admission. Forty-one patients in extremis (group A; ISS: 40.1±11.1 patients) which required the highest resuscitation efforts revealed a mortality rate of 90%. Many of these patients underwent crash laparotomy (44%)/thoracotomy (22%), aortic clamping (22%), and pelvic packing (44%). Patients with persistent hemodynamic instability (group B; n = 39; ISS: 34.2±9.6 patients) had a mortality rate of 26% (p〈0.05 versus group A) with 14 patients (36%) undergoing emergency laparotomy. Mortality rate (5%) markedly (p〈0.05) decreased in patients with stable hemodynamics despite a relatively high ISS (group C; n = 94; ISS: 27.6±9.4 patients). Hemorrhage could be controlled in all patients of group B and C, while 23 out of 41 patients (56%) in extremis died due to exsanguination during the first 24 hours after injury. Thus, treatment of patients in extremis must be focused on aggressive resuscitation and surgical intervention without extensive diagnostic procedures to effectively control lethal hemorrhage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00002452
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    A new formula for speedup and its characterization (1997)
    Springer
    Acta informatica 34 (1997), S. 637-652 
    Details
    ISSN: 1432-0525
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Notes: Abstract. We address the task of measuring the relative speed (speedup) of two systems $A$ and $B$ for solving the same problem. For example, $B$ may be a parallel algorithm, parametrized by the number of processors used, whose running time has to be related to a serial standard algorithm $A$ . If $A$ and/or $B$ are randomized or if we are interested in their performance on a (discrete) probability distribution of problem instances, the running times are described by random variables $T^A$ and $T^B$ . The speedup of $B$ over $A$ is usually defined as $E(T^A)/E(T^B)$ where $E$ denotes the expected value. In many cases this definition is not appropriate for the user of $A$ or $B$ , because the summation in $E(T^A)$ and $E(T^B)$ hides information about the speedup of individual runs. We propose an alternative speedup definition of the form $M(T^A/ T^B)$ and present a set of intuitive functional equations, which any such function $M(T^A/T^B)$ should fulfill. Finally, we prove that the weighted geometric mean is the only solution of these equations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002360050100
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    Paper (German National Licenses)
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  • 4
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    SLCV – A Supervised Learning - Computer Vision combined strategy for automated muscle fibre detection in cross sectional images (2019)
    Details
    Publication Date: 2020-11-24
    Description: Muscle fibre cross sectional area (CSA) is an important biomedical measure used to determine the structural composition of skeletal muscle, and it is relevant for tackling research questions in many different fields of research. To date, time consuming and tedious manual delineation of muscle fibres is often used to determine the CSA. Few methods are able to automatically detect muscle fibres in muscle fibre cross sections to quantify CSA due to challenges posed by variation of bright- ness and noise in the staining images. In this paper, we introduce SLCV, a robust semi-automatic pipeline for muscle fibre detection, which combines supervised learning (SL) with computer vision (CV). SLCV is adaptable to different staining methods and is quickly and intuitively tunable by the user. We are the first to perform an error analysis with respect to cell count and area, based on which we compare SLCV to the best purely CV-based pipeline in order to identify the contribution of SL and CV steps to muscle fibre detection. Our results obtained on 27 fluorescence-stained cross sectional images of varying staining quality suggest that combining SL and CV performs signifi- cantly better than both SL based and CV based methods with regards to both the cell separation- and the area reconstruction error. Furthermore, applying SLCV to our test set images yielded fibre detection results of very high quality, with average sensitivity values of 0.93 or higher on different cluster sizes and an average Dice Similarity Coefficient (DSC) of 0.9778.
    Language: English
    Type: article , doc-type:article
    Format: application/pdf
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  • 5
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    Discerning the spatio-temporal disease patterns of surgically induced OA mouse models (2019)
    Details
    Publication Date: 2020-11-24
    Description: Osteoarthritis (OA) is the most common cause of disability in ageing societies, with no effective therapies available to date. Two preclinical models are widely used to validate novel OA interventions (MCL-MM and DMM). Our aim is to discern disease dynamics in these models to provide a clear timeline in which various pathological changes occur. OA was surgically induced in mice by destabilisation of the medial meniscus. Analysis of OA progression revealed that the intensity and duration of chondrocyte loss and cartilage lesion formation were significantly different in MCL-MM vs DMM. Firstly, apoptosis was seen prior to week two and was narrowly restricted to the weight bearing area. Four weeks post injury the magnitude of apoptosis led to a 40–60% reduction of chondrocytes in the non-calcified zone. Secondly, the progression of cell loss preceded the structural changes of the cartilage spatio-temporally. Lastly, while proteoglycan loss was similar in both models, collagen type II degradation only occurred more prominently in MCL-MM. Dynamics of chondrocyte loss and lesion formation in preclinical models has important implications for validating new therapeutic strategies. Our work could be helpful in assessing the feasibility and expected response of the DMM- and the MCL-MM models to chondrocyte mediated therapies.
    Language: English
    Type: article , doc-type:article
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    OPUS
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