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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 148 (1989), S. 589-589 
    ISSN: 1432-1076
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 151 (1992), S. 775-778 
    ISSN: 1432-1076
    Keywords: Nephrotic syndrome ; Steroid-dependent idiopathic nephrotic syndrome ; Cyclosporin A ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Therapy of steroid-dependent idiopathic nephrotic syndrome is often unsatisfactory. Since 1986 we have treated nine children (six male and three female), aged 3–16 years, with cyclosporin A (CsA) during 2.0–5.2 (median 3.1) years. All had minimal change disease on renal biopsy and had previously received cyclophosphamide. Mean daily dosage of CsA was 4.1 mg/kg (range 2.7–5.8) and mean whole blood trough level was 220ng/ml (range 141–271). The relapse rate decreased from 3.4/patient year before CsA to 0.55 on CsA. Discontinuation of CsA or reduction below 2 mg/kg daily was always followed by a relapse. The overall relapse rate, including the period with very low-dose CsA, was 0.95/patient year. Four patients required additional low-dose alternate-day prednisone. Repeat renal biopsy showed minimal change disease in eight patients and focal segmental glomerulosclerosis in one; CsA-toxicity was mild in two and moderate in one. The latter was the only patient with slightly reduced glomerular filtration rate. Two boys with delayed puberty spontaneously matured and reached expected final height. We conclude that long-term low-dose CsA is very effective and steroid-sparing. Its use is justified in selected patients, particularly in those with numerous relapses and in male patients before and during puberty, as long as renal function and CsA-toxicity are carefully monitored.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1432-1076
    Keywords: Neonate ; Ceftriaxone ; Bilirubin binding interaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The in vivo bilirubin-albumin binding interaction of ceftriaxone (CRO) was investigated in 14 nonjaundiced newborns, aged 33–42 weeks of gestation, during the first few days of life after they had reached stable clinical condition. CRO (50 mg/kg) was infused intravenously over 30 min. The competitive binding effect of CRO on the bilirubin-albumin complex was estimated by determining the reserve albumin concentration (RAC) at baseline, at the end of CRO infusion, and at 15 and 60 min thereafter. Immediately after the end of drug administration, RAC decreased from 91.9 (±25.1) μmol/l to 38.6 (±10.1) μmol/l (P=0.0001). At the same time the plasma bilirubin toxicity index (PBTI) increased from 0.64 (±0.40) before drug infusion to 0.96 (±0.44) thereafter (P=0.0001). The highest displacement factor (DF) was calculated to be 2.8 (±0.6) at the end of drug infusion. Average total serum bilirubin concentrations decreased from a baseline value of 59.6 (±27.0) μmol/l to 55.2 (±27.1) μmol/l (P=0.026). Sixty minutes after the end of CRO infusion, RAC was 58.3 (±21.7) μmol/l, PBTI regained baseline, but DF was still 1.9 (±0.2). No adverse events were recorded. Our results demonstrate significant competitive interaction of CRO with bilirubin-albumin binding in vivo. Thus, cefriaxone should not be given to the neonate at risk of developing bilirubin encephalopathy.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    European journal of pediatrics 149 (1990), S. 560-564 
    ISSN: 1432-1076
    Keywords: Acute mastoiditis ; Subperiosteal abscess ; Central nervous system ; Microbiology ; Treatment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The charts of 73 children (31 girls, 42 boys) aged 4 months to 14 years (mean 4.5 years) with acute mastoiditis managed during a 16-year period were reviewed. Of the patients 36% were less than 24 months old. Retro-auricular swelling was described in 63 of the 73 children, tenderness in 59, erythema in 58, and protrusion of the auricle in 45. A pathological tympanic membrane was noted in 33% of the patients and fever in only 29%. Apart from local inflammation, the most frequent complaints and symptoms were otalgia (n=42), recent upper respiratory tract infections (n=22), and fever alone (n=22). A subperiosteal abscess was found in 36 patients, and CNS involvement in 5. Nearly half of the patients (48%) were on antibiotic therapy at admission. The isolation rates in bacterial cultures from subperiosteal aspirates (81%) and from mastoid mucosa (68%) were considerably higher than from blood cultures (14%) and were not influenced by previously administered antibiotics. Pneumococci (9/32) andStaphylococcus epidermidis (6/32) were the agents most often isolated. The incidence of the bacteria isolated from patients pre-treated with antibiotics differed from the incidence in patients not previously treated. In 24 patients (33%) the lesion healed with antibiotic therapy without mastoid surgery. Myringotomy and the insertion of a ventilation tube is indicated initially, if acute otitis media with effusion is found. In the absence of a subperiosteal abscess and of CNS involvement, a 48-hour trial of intravenous antibiotic therapy, directed also against staphylococci, is justified before mastoid surgery is considered.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Lung 117 (1958), S. 539-556 
    ISSN: 1432-1750
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Zusammenfassung Beschreibung eines Falles von chronischer Bronchiolitis obliterans mit progressiver kardio-respiratorischer Insuffizienz, welcher die Patientin nach 10jähriger Krankheitsdauer in ihrem 45. Lebensjahre erliegt. In den Lungen ist eine Großzahl von Bronchioli respiratorii in allen Lappen narbig obliteriert. Folgeerscheinungen dieser Narbenbildungen sind fokales Emphysem, Emphysema bronchiolectaticum, cystische Bronchiektasen (sekundäre Wabenlunge). Das obstruktive Emphysem mit der Lungenstarre und der beträchtlichen Totraumvermehrung führte frühzeitig über den alveolo-vasculären Reflex zur pulmonalen Hypertension und schließlich zum chronischen Cor pulmonale. Die Ätiologie der Bronchiolitis obliterans ist ungeklärt. Eingehene Besprechung der Pathophysiologie der Bronchiolitis obliterans.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Two families with X-linked dominant hypophosphatemia (McKusick No. *30780) were investigated for linkage of the disease locus with several marker genes defined by cloned, single-copy DNA sequences derived from defined regions of the X chromosome. Close linkage was found with DNA markers DXS41 (p99-6) and DXS43 (pD2) at Xp22, suggesting a location of the HPDR gene on the distal short arm of the X chromosome.
    Type of Medium: Electronic Resource
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