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  • 1
    Electronic Resource
    Electronic Resource
    Verminderte Phytohämagglutinin-Stimulation von menschlichen Lymphozytenkulturen bei Leberzirrhose: Untersuchungen mit3H-Thymidin und125J-Desoxyuridin (1970)
    Springer
    Annals of hematology 20 (1970), S. 370-377 
    Details
    ISSN: 1432-0584
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Lymphocyte cultures of normal individuals and of patients suffering either from chronic hepatite or from liver cirrhosis were stimulated with phytohaemagglutinin. 3 days later the cultures were pulse-labeled either with I125-deoxyuridine or with H3-thymidine in order to determine the rate of DNA-synthesis. The lymphocytes from patients with liver cirrhosis exhibited a significantly lower response to PHA, whereas no difference in the uptake of activity could be recognized between normal individuals and patients with chronic hepatite. Liver extract obtained from a healthy person was not able to induce DNA-synthesis in the lymphocyte cultures of the 3 groups of patients. I125-deoxyuridine proved to be a simple and valuable tool to determine the proliferative capacity (DNA-synthesis) in a lymphocyte culture, suitable for differential diagnosis of liver diseases.
    Notes: Zusammenfassung Leukozytenkulturen von Normalpersonen, Patienten mit chronischer Hepatitis und solchen mit Zirrhose wurden 3 Tage nach Stimulation mit Phytohämagglutinin mit den spezifischen DNS-Vorläufern125J-Desoxyuridin oder3H-Thymidin markiert. Dabei ist der Gebrauch von Joddesoxyuridin technisch einfacher und liefert schnelle und reproduzierbare Resultate. Die Lymphozyten von Patienten mit Zirrhose zeigten eine signifikant erniedrigte Ansprechbarkeit der DNS-Synthese auf Phytohämagglutinin, während zwischen Normalpersonen und Hepatitiskranken kein Unterschied in der eingebauten Aktivität festgestellt wurde. Homologer Leberextrakt einer gesunden Spenderin verursachte keine Induktion der DNS-Synthese in Lymphozytenkulturen von allen 3 Patientengruppen. Die Bestimmung der Proliferationsaktivität (DNS-Synthese) von Lymphozytenkulturen mit Hilfe von125J-Desoxyuridin erwies sich als zuverlässige, technisch einfache Methode, die für die klinische Diagnostik einsetzbar ist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01634047
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  • 2
    Electronic Resource
    Electronic Resource
    Selenium and myocardial infarction: Glutathione peroxidase in platelets (1981)
    Springer
    Journal of molecular medicine 59 (1981), S. 817-818 
    Details
    ISSN: 1432-1440
    Keywords: Selenium ; Glutathione peroxidase ; Platelets Thrombosis ; Myocardial infarction ; Selen ; Glutathionperoxidase ; Thrombozyten ; Thrombose ; Herzinfarkt
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Die Aktivität des Selenenzyms Glutathionperoxidase (EC 1.11.1.9) wurde in den Blutplättchen von 15 Patienten mit frischem Herzinfarkt und 13 Kontrollpersonen gemessen. Die Blutplättchen der Patienten zeigten signifikant niedrigere Enzymaktivitäten (P(t)〉0.99). Möglicherweise steht dies mit der Erkrankung in pathogenetischem Zusammenhang.
    Notes: Summary The activity of the selenoenzyme glutathione peroxidase (EC 1.11.1.9) was determined in platelets of 15 patients with acute myocardial infarction and 13 control subjects. The platelets of the patients had significantly lower activities of the enzyme (P(t)〉0.99). This may be related to the pathogenesis of the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01724689
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  • 3
    Electronic Resource
    Electronic Resource
    Hair selenium content during infancy and childhood (1982)
    Springer
    European journal of pediatrics 139 (1982), S. 295-296 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Hair ; Infants ; Children
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Hair selenium content was estimated by instrumental neutron activation analysis in Libyan infants and children. There was no significant difference between the values of young infants from North and South Libya. The hair selenium content rapidly decreased from 1071 ±75 ng/g in newborns to 301±99 ng/g in 7–10 months old infants in North Libya and to 557±204 ng/g in South Libya. In North Libya the values of preschool children were 409±117 ng/g and those of school children 464±124 ng/g.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442184
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  • 4
    Electronic Resource
    Electronic Resource
    Primary hypomagnesemia (1975)
    Springer
    European journal of pediatrics 118 (1975), S. 249-258 
    Details
    ISSN: 1432-1076
    Keywords: Primary hypomagnesemia ; Hypocalcemia ; Intestinal absorption ; Magnesium ; Whole body counter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der klinische Verlauf zweier Patienten mit primärer Hypomagnesämie wird beschrieben. Bei einem Patienten, einem 5 Monate alten Säugling, wurden Magnesiumretention,-resorption,-Stuhlausscheidung und-Clearance gemessen. Die Retention (2,8%) und Resorption (7,8%) von Magnesium28 war deutlich erniedrigt im Vergleich zu Kontrollpersonen, die durchschnittlich 25% retinierten und 28% absorbierten. Zwischen den Retentionswerten der Eltern und Verwandten und denen der gesunden Erwachsenen bestand kein Unterschied. Der untersuchte Patient wurde erfolgreich mit Trimagnesiumdicitrat, entsprechend einer Dosis von 1,75 g Magnesium, behandelt.
    Notes: Abstract The clinical course of 2 patients with primary hypomagnesemia is reported. In one male patien, 5 months old, measurements of magnesium retention, intestinal absorption, fecal excretion and renal clearance were performed. The retention (2.8%) and absorption (7.8%) of 28-Mg were markedly reduced in comparison to controls (average retention 25% and average absorption 28%). The retention values of the parents and other relatives did not differ from those of healthy adults. The examined patient was successfully treated with trimagnesium dicitrate containing 1.75 g magnesium per day.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00492330
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  • 5
    Electronic Resource
    Electronic Resource
    The selenium state of children (1978)
    Springer
    European journal of pediatrics 128 (1978), S. 213-223 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Gluthathione peroxidase ; Dietotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selenium content of serum, whole blood and hair was measured by neutron activation analysis in dietetically treated patients with phenylketonuria (PKU) and maple-syrup-urine disease (MSUD). Follow-up studies showed a decrease of the serum selenium content and the glutathione peroxidase activity of erythrocytes—a selenoenzyme—from normal values at the beginning of the diet to 20% (selenium) and 50% (gluthione peroxidase) of normal within 10–12 weeks of dietary treatment. In 36 patients the serum selenium content was lower at 6.7–28×10-9 g/ml, independent of the age of the patients (0.5 to 10 years). The selenium content of whole blood was reduced: median=98×10-9 g/g dry weight; range 75 to 165×10-9 g/g dry weight (healthy children: median=381×10-9 g/g dry weight; range 245 to 588×10-9 g/g dry weight). The selenium content of hair was markedly lower in the patients (median=62×10-9 g/g; range 13–140×10-9 g/g) than in healthy children (median=429; range 213 to 720×10-9 g/g). The mean glutathione peroxidase activity of erythrocytes was reduced to 4.6±0.64 U37/g Hb, in comparison to normal values (mean=8.8±0.88 U37/gHb).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445606
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  • 6
    Electronic Resource
    Electronic Resource
    Selenium content of human milk, cow's milk and cow's milk infant formulas (1978)
    Springer
    European journal of pediatrics 129 (1978), S. 139-145 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Human milk ; Cow's milk ; Cow's milk infant formula
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The selenium content of human milk, cow's milk and cow's milk infant formula were estimated by instrumental neutron activation analysis. The highest values were found in 3 samples of human colostrum (524–865×10-9 g/g dry weight). There was a significant decrease with increasing time post partum. Mature human milk exhibited a selenium content of 230±79×10-9 g/g dry weight. The selenium content of 45 samples of cow's milk from the north-western area of Germany was 200±39×10-9 g/g dry weight. While there was no significant difference between the values of mature human milk and of cow's milk, cow's milk infant formula exhibited significantly (P〈0.01) lower values than human milk. The average selenium content of 107 samples of 10 different commercially available fluid and powdered cow's milk infant formulas (range: 18–171×10-9 g/g dry weight) amounted to about only one third of that in mature human milk.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442157
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  • 7
    Electronic Resource
    Electronic Resource
    Serum zinc concentration during childhood (1977)
    Springer
    European journal of pediatrics 126 (1977), S. 199-202 
    Details
    ISSN: 1432-1076
    Keywords: Zinc ; Serum ; Normal values ; Children ; Infants ; Cord blood ; Adults
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Serum zinc concentrations in subjects of different ages were estimated by neutron activation analysis to obtain reliable reference values for the diagnosis of primary or secondary zinc deficiency during childhood. In these healthy individuals a small age-dependent variation of the mean values was found. Serum zinc concentrations were lower in cord blood (mean value: 880×10−9 g/ml) and in infants (mean value: 820×10−9 g/ml) than in adults (mean value 1178×10−9 g/ml). In comparison to these values, the serum zinc concentration in a patient with secondary zinc deficiency and 4 patients with acrodermatitis enteropathica was reduced to about 25% of normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00477045
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  • 8
    Electronic Resource
    Electronic Resource
    Akrodermatitis enteropathica — eine Zinkstoffwechselstörung mit Zinkmalabsorption (1975)
    Springer
    European journal of pediatrics 120 (1975), S. 181-189 
    Details
    ISSN: 1432-1076
    Keywords: Acrodermatitis enteropathica ; Zinc ; Malabsorption ; Therapy ; Zinc retention ; Zinc elimination ; Whole body counter
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 3 Patienten mit Akrodermatitis enteropathica wurde mit Hilfe der Ganzkörpermessung nach oraler Applikation von 65Zn eine verminderte intestinale Zinkresorption gedunden. Dagegen war die Zinkelimination aus dem Körper normal. Die Zinkkonzentration im Serum war bei den Patienten stark erniedrigt. Alle klinischen Symptome verschwanden nach sehr hohen oralen Zinkdosen. Diese Befunde sprechen um so mehr für eine ursächliche Rolle des Zinks in der Pathogenese der Akrodermatitis enteropathica, als bei dieser Krankheit ultrastrukturelle Veränderungen in den Panethschen Zellen nachzuweisen sind [12], die auch beim Zinkmangel der Ratten gefunden wurden [Beitr. Path. 145, 336 (1972)].
    Notes: Abstract The intestinal resorption of zinc using 65ZnCl2 was estimated in 3 patients with acrodermatitis enteropathica, 2 healthy controls, and 3 heterozygotes. After oral application of 65Zn the whole body activity was measured by a whole body counter for 34 days. The 65Zn resorption of the patients amounted to 16, 42 and 30% of the applied dose, whereas the resorption values of the heterozygotes and the controls were in the range of 58 and 77%. The elimination of 65Zn from the body amounted to about 0.7% of the applied dose with no difference between controls and patients with acrodermatitis enteropathica. Before therapy the serum-zinc levels of patients were markedly decreased. After oral application of high doses of zinc aspartate (2×400 mg/day) all clinical symptoms disappeared within a week. The results point at a causal connection between zinc and the pathogenesis of acrodermatitis enteropathica. Ultrastructural alterations of the Paneth cells of the intestine are also shown in this disease [12] as have also been seen in Paneth cells of zinc deficient rats [Beitr. Path. 145, 336 (1972)].
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00439007
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  • 9
    Electronic Resource
    Electronic Resource
    Selenium requirements in patients with inborn errors of amino acid metabolism and selenium deficiency (1980)
    Springer
    European journal of pediatrics 134 (1980), S. 65-68 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Glutathione peroxidase ; Selenium deficiency ; Selenium supplementation ; Nutrition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The diets of 5 patients with phenylketonuria or maple-syrup-urine disease were supplemented with yeast which was rich in selenium. For 120 days the patients received 45 μg Se/day to increase the Se content of their diets to 10–12ng Se/Kjoule. Before supplementation the selenium content of serum (5–15 ng/ml) and whole blood (10–27 ng/ml), and the activity of the erythrocyte glutathione peroxidase (0.19–2.69 U37/g Hb), amounted to only 10–20% of normal. The serum selenium content reached normal values within 4 weeks of supplementation, followed by normalisation of the selenium content of whole blood within 4–8 weeks. Restoration of the activity of erythrocyte glutathione peroxidase took 9 to 15 weeks —the red cell life span. There was a significant positive correlation between the selenium content of the erythrocytes and the activity of erythrocyte glutathione peroxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00442405
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  • 10
    Electronic Resource
    Electronic Resource
    Selenium intake of infants and young children, healthy children and dietetically treated patients with phenylketonuria (1984)
    Springer
    European journal of pediatrics 143 (1984), S. 99-102 
    Details
    ISSN: 1432-1076
    Keywords: Selenium ; Intake ; Children ; Phenylketonuria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In 20 healthy infants and children, 5–20 months old, the Se intake was estimated by analysing food samples by instrumental neutron activation analysis. The intake was calculated by weighing the portions offered and actually consumed. The median Se content of the food amounted to 27 ng/g wet weight (gww) and median daily Se intake to 33.5 μg. The Se intake was not equally distributed over the day. About 50% of the daily Se intake was derived from the supper. The main Se sources (41%) for young children were cereal paps. Commercially, available meals (30 ng/g) contained less Se than home-made ones (50 ng/g). In nine dietetically treated patients with phenylketonuria the median Se intake amounted only to 6.9 μg/day corresponding to a mean Se content of the diet of 7.9 ng/g. The main Se source in the diet was vegetables (36.3%) and 20% derived from their protein supplements. The Se intake of young children, healthy or dietetically treated, cannot be calculated accurately from tables but must be estimated by measuring the Se content of the local food because cereals and vegetables-the main Se sources-exhibit great regional variations.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00445794
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