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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 5 (1983), S. 103-113 
    ISSN: 1279-8517
    Keywords: Pancreas ; Vein ; Anatomy ; Pancreatic phlebography ; Endocrine tumor of pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé L'anatomie des veines du pancréas bénéficie d'un regain d'intérêt depuis que la phlébographie pancréatique avec prélèvements sanguins sélectifs est venue enrichir les moyens de localisation des tumeurs endocrines du pancréas. Basée sur l'étude de 50 pièces d'injection-corrosion, leur description permet de retrouver la dualité anatomochirurgicale de la glande. Le pancréas droit est drainé par 4 veines relativement constantes mais dont l'importance est inégale. Les veines pancréatico-duodénales supérieures (PDPS et PDAS) rejoignent la veine porte et le système du tronc gastrocolique; par l'étendue de leur territoire de drainage, elles représentent les pédicules céphaliques principaux. Les veines pancréatico-duodénales inférieures (PDPI et PDAI) gagnent le plus souvent les veines jéjunales et s'abouchent plus rarement dans la veine mésentérique supérieure. Le pancréas rétro-veineux fait partie du pancréas droit; son drainage est assuré non seulement par les veines pancréatico-duodénales postérieures et la veine pancréatico-duodénale antéro-inférieure mais aussi par une ou deux petites veines implantées à la face postérieure de la veine mésentérique supérieure (veine du pancréas rétro-veineux). La pancréas gauche est drainé par un grand nombre de petites veines qui gagnent la face antérieure de la veine liénale. La veine pancréatique inférieure existe dans la moitié des cas et représente alors le second axe de son drainage. Plus accessoire ment, les veines gastriques gauches, la veine mésentérique inférieure et la veine colique moyenne peuvent y prendre part. Le pancréas pré-veineux représente la charnière anatomique et chirurgicale entre ces deux ensembles; son drainage emprunte le plus souvent les veines adjacentes mais il est parfois aussi assuré par des veines isthmiques propres qui gagnent la face antérieure du tronc mésentérico-portal. A l'issue de cette description, un protocole d'exploration phlébographique est proposé. La multiplication des dosages hormonaux sélectifs doit permettre de déjouer les erreurs de localisation tumorale liées aux riches connections anastomotiques des veines du pancréas.
    Notes: Summary The anatomy of the pancreatic veins has become the object of renewed interest due to the advent of pancreatic phlebography coupled with selective blood sampling to diagnose the site of endocrine tumors of this organ. This study, based on the examination of 50 postmortem glands prepared by the technique of injection-corrosion, was undertaken to identify the veins of the pancreas and establish anatomicosurgical correlations. The right pancreas is drained by four relatively constant veins of unequal importance. The two superior pancreaticoduodenal veins (posterosuperior and anterosuperior) join with the portal vein and gastrocolic venous trunk. Due to their large drainage territory these veins are the main routes of cephalic pancreatic venous return. The inferior pancreaticoduodenal veins (posteroinferior and anteroinferior) most often run into the jejunal veins and less frequently end in the superior mesenteric vein. A part of the right pancreas can be referred to as the retrovenous segment. Drainage of this territory is via the anteroinferior and both posterior pancreaticoduodenal veins as well as by one or two small veins (veins of the retrovenous pancreas) which merge with the posterior surface of the superior mesenteric vein. The left part of the pancreas is drained by numerous small venous tributaries of the vena lienalis. A second drainage axis, present in half of the cases studied, is the inferior pancreatic vein. The left gastric, inferior mesenteric and middle colic veins afford an accessory route of drainage of the left pancreas. The anatomical and surgical junction between the right and left parts of the pancreas can be referred to as the prevenous segment. The drainage of this segment is most often via the neighboring veins, although in some cases may be via true isthmic veins, which join the anterior surface of the mesentericoportal trunk. A protocol for the phlebographic exploration of the pancreas is proposed, based on these anatomical findings. Taking multiple selective samples of venous blood for hormone determinations should allow reduction of the error of tumor localization related to the rich network of venous anastomoses in the pancreas.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 6 (1984), S. 79-85 
    ISSN: 1279-8517
    Keywords: Anatomy ; Lateral thoracotomy ; Muscle transection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Un rappel de l'anatomie descriptive de la paroi latérale du thorax et de l'anatomie topographique du cinquième espace intercostal sert de base à la description de la thoracotomie latérale sans section musculaire considérée par les auteurs comme une voie d'abord “standard” du thorax.
    Notes: Summary The descriptive anatomy of the lateral thoracic wall and the topographical anatomy of the fifth intercostal space are used as bases for the description of the lateral approach to the thoracic cavity without muscle transection, considered by the authors as a “standard” approach to the thoracic cavity.
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1279-8517
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Surgical and radiologic anatomy 3 (1981), S. 183-193 
    ISSN: 1279-8517
    Keywords: plastie colique ; côlon ; vascularisation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Résumé L'œsophagoplastie colique est actuellement une technique bien connue et la plus utilisée pour remplacer l'œsophage en partie ou en totalité. Ce succès repose sur deux particularités anatomiques du côlon: - une longueur suffisante qui lui permet d'atteindre le cou; la longueur nécessaire est variable avec le morphotype du sujet; - une vascularisation artérielle et veineuse convenables. Ces deux points sont étudiés successivement. Les artères des côlons sont le sujet de très nombreuses publications apportant un grand nombre d'observations; la seule difficulté lorsqu'il s'agit de les rapprocher les unes des autres tient au vocabulaire très différent des divers auteurs. Cette vascularisation qui comporte des piliers peu nombreux réunis par des arcades anastomotiques, telle celle de Riolan le long du transverse, la plus constante, se prête remarquablement à ces tentatives d'œsophagoplastie. Quelques zones le long du côlon ascendant ou de l'angle gauche peuvent avoir une irrigation plus précaire. Les veines moins souvent étudiées sont satellites des artères et ne posent donc pas de problème particulier. Le seul point essentiel pour respecter au mieux cet apport vasculaire est de disséquer jusqu'au contact des axes mésentériques l'origine des piliers pour conserver le V d'une division précoce. A partir de la description des piliers, les principales catégories d'OPC à pédicule droit ou gauche sont rappelées. A côté de ces éléments fondamentaux, le cheminement de la plastie est envisagé et les différentes parois du tunnel rétrosternal sont décrites. Les notions de plastie péristaltique ou anisopéristaltique sont évoquées et le problème des ulcères du côlon transposé est abordé.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 366 (2000), S. 433-437 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Laboratory facilities and methods are presented for the determination of ultra-low levels of mercury (Hg) in ice and snow samples originating from polar ice caps or temperate regions. Special emphasis will be given to the presentation of the clean laboratory and the cleaning procedures. The laboratory is pressurized with air filtered through high efficiency particle filters. This first filtration is not enough to get rid of contamination by Hg in air. Experiments are conducted in a clean bench, especially built for Hg analysis, equipped with both particle filter and activated charcoal filter. It allows to obtain very low levels of atmospheric Hg contamination. Ultrapure water is produced for cleaning all the plastic containers that will be used for ice and snow samples and also for the dilution of the standards. Hg content in laboratory water is about ¶0.08 ± 0.02 pg/g. A Teflon system has been developed for the determination of Hg in ice and snow samples based on Hg(II) reduction to Hg(0) with a SnCl2/HNO3 solution followed by the measurement of gaseous Hg(0) with a Hg analyzer GARDIS 1A+ based on the Cold Vapor Atomic Absorption Spectroscopy method. Blank determination is discussed.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1041
    Keywords: loperamide ; opiate agonist ; pituitary hormones ; glucose ; free fatty acids ; insulin ; C-peptide ; metabolic effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of acute oral administration of loperamide (4, 8 and 16 mg), a peripheral opiate agonist used in the treatment of diarrhoea, on several metabolic and endocrine variables has been evaluated in healthy volunteers in comparison with placebo. Plasma glucose was significantly raised by all three doses, whereas serum IRI and C-peptide were decreased and serum FFA was significantly increased only after loperamide 8 and 16 mg; serum PRL, GH, LH and FSH did not change. The data suggest that opiates may be involved in the regulation of glycaemia, probably by modifying islet hormone secretion by acting at a peripheral site, since loperamide does not cross the blood-brain barrier. Although the precise mechanism of these actions is unknown, it is suggested that the effects of loperamide are mediated either by stimulation of opiate receptors per se, or by suppression of acetylcholine release from cholinergic nerve endings. The lack of change in pituitary hormone secretion by loperamide is in agreement with previous observations indicating that opiate effects on PRL, GH and gonadotropins occur at the level of the central nervous system.
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1432-1041
    Keywords: dihydroergokryptine ; acromegaly ; hyperprolactinaemia ; prolactin ; growth hormone ; l-DOPA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The endocrine effects of a relatively potent dopaminergic agent, dihydroergokryptine, have been studied in normal subjects, and in hyperprolactinaemic and acromegalic patients. A single 6 mg oral dose of the drug caused a marked, long lasting fall in prolactin (PRL) plasma levels in healthy subjects, in hyperprolactinaemic patients and in normoprolactinaemic acromegalics. Growth hormone (GH) levels decreased in l-DOPA — responder, acromegalic patients, but dihydroergokryptine did not affect GH levels in normal volunteers or in l-DOPA non — responder, acromegalic patients. The PRL-and GH- lowering activity of 6 mg dihydroergokriptine was significantly greater than that of 6 mg dihydroergocristine, and was similar to that of an oral dose of 500 mg l-DOPA.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1041
    Keywords: FCE20700 ; gastric secretion ; antisecretory activity ; mucoprotein release ; bicarbonate release ; serum gastrin ; healthy volunteers ; PGE2 derivative ; cytoprotection ; side-effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacodynamic effects of FCE20700, a new PGE2 derivative, have been investigated in 6 healthy volunteers given single intragastric (i.g.) and intraduodenal (i.d.) doses of 1 and 2 mg and placebo, according to a double-blind, within — subjects design. For 30–270 min following i.g. administration the effect of FCE20700 on peptone-stimulated gastric acid secretion (AS) was assessed by i.g. titration, and serum gastrin (G) levels were also determined. For the same period after i.d. dosing the effect of the compound on pentagastrin-stimulated AS and on mucoproteins and bicarbonate content in the gastric juice was measured. Blood pressure (BP), heart rate and possible side-effects were monitored. Following i.g. administration there was a moderate, dose-related, significant inhibition of AS; significant inhibition of G levels was observed only after the highest dose. After i.d. administration there was a very modest through dose-related and significant inhibition of AS; a brief maximal increase in mucoproteins and in bicarbonate levels was apparent after the 1 mg dose. After i.d. but not after i.g. administration of 2 mg there was a modest but significant decrease in BP. No side-effects of clinical relevance were reported. The results appear to suggest a major activity of FCE20700 on cytoprotection rather than in inhibiting gastric acid secretion. The observed change in BP may indicate that after i.d. administration there will be some systemic effects of FCE20700.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1432-1041
    Keywords: cyproheptadine ; metergoline ; glucose tolerance ; insulin secretion ; chemical diabetes ; man
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of short-term treatment with either placebo or two serotonin antagonists, cyproheptadine and metergoline, on oral glucose tolerance and insulin secretion have been evaluated in normal subjects and in patients with chemical diabetes. Placebo treatment was not associated with any significant change in the parameters examined. Glucose tolerance in chemical diabetics was significantly improved both after cyproheptadine and metergoline; fasting plasma glucose was also reduced by metergoline. Treatment with the latter drug was also associated with a significant decrease in incremental glucose area in healthy subjects, which was not affected by cyproheptadine. Basal and glucose-stimulated insulin secretion were not affected by either drug in any subjects. Cyproheptadine and metergoline improve glucose metabolism in chemical diabetes probably by reducing insulin resistance. This may depend either on decreased secretion of counter-regulatory hormones or on a direct pharmacological action of the drugs on glucose utilization, possibly mediated by their common antiserotoninergic properties.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1041
    Keywords: serotonin ; methysergide ; metergoline ; metoclopramide ; gastric acid secretion ; gastrin secretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects of acute oral administration of the antiserotoninergic drugs methysergide (3 mg) and metergoline (4 mg) on basal, submaximal (0.6 µg/kg i. m.) and maximal (6 µg/kg) pentagastrinstimulated gastric acid secretion, as well as on basal and food-induced gastrin release, have been evaluated in healthy volunteers. Methysergide significantly increased basal and submaximal pentagastrin-stimulated gastric acid secretion, and metergoline significantly inhibited gastric acidity in all experiments. Basal and stimulated serum gastrin concentrations were not modified by either drug. The effect of methysergide on gastric acid secretion was opposed to that of serotonin and was probably dependent on its antiserotoninergic action, but the decrease in gastric acidity caused by metergoline is not easily explained. Although the effect is similar to that of a dopamine infusion, it does not depend on dopamine receptor stimulation, since it was not influenced by pretreatment with metoclopramide. It is suggested that it might be due to the weak anticholinergic and/or antihistaminic properties of metergoline.
    Type of Medium: Electronic Resource
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