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  • 1
    Electronic Resource
    Electronic Resource
    Susceptibility toHerpesvirus saimiri and antibody development in old and new world monkeys (1973)
    Springer
    Medical microbiology and immunology 158 (1973), S. 227-236 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Herpesvirus saimiri (HVS) induzierte in vier cotton topped (CT) Marmosets (S. oedipus) ein malignes Lymphom. Lymphoide Zellen aus dem Tumorgewebe eines CT Marmoset wurden in einen white lipped (WL) Marmoset (S. nigricollis) transplantiert. Das Empfängertier entwickelte ein generalisiertes malignes Lymphom. Die Inoculation von HVS und die Transplantation von Tumorzellen induzierte jedoch keinen Tumor in neun ausgewachsenen Cercopithecus aethiops-Affen. Ein 32 Tage altesCallithrix jacchus-Baby starb an einem malignen Lymphom nach Infektion mit HVS. Alle ausgewachsenen Neuweltaffen (S. oedipus, S. nigricollis, Callithrix jacchus), die einmal mit HVS oder Tumorzellen inoculiert worden waren, bildeten neutralisierende Antikörper gegen HVS in gleicher Titerhöhe, unabhängig davon, ob sie einen Tumor entwickelten oder nicht. In den Seren der Altweltaffen (Cercopithecus aethiops), die mit HVS oder Tumorzellen inoculiert worden waren, konnten keine neutralisierenden Antikörper nachgewiesen werden.
    Notes: Abstract Herpesvirus saimiri (HVS) induced malignant lymphoma in four cotton-topped (CT) marmosets (S. oedipus). The tumor of a CT marmoset was transplanted to a white-lipped (WL) marmoset (S. nigricollis) which developed malignant lymphoma. The inoculation of HVS and the transplantation of tumor cells did not induce malignant lymphoma in nine adultCallithrix jacchus monkeys and six adultCercopithecus aethiops monkeys. A 32-day-old Callithrix jacchus baby monkey died with malignant lymphoma after infection with HVS. All adult animals of the New World monkey species (S. oedipus, S. nigricollis, Callithrix jacchus) inoculated once with HVS or tumor cells developed equally high titers of neutralizing antibodies against HVS whether they developed a tumor or not. No neutralizing antibodies were detectable in the sera of the Old World monkeys (Cercopithecus aethiops) inoculated with HVS or tumor cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02120558
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  • 2
    Electronic Resource
    Electronic Resource
    Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins (1997)
    [s.l.] : Macmillan Magazines Ltd.
    Nature 390 (1997), S. 184-187 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The passage of mammalian cells through the restriction point into the S phase of the cell cycle is regulated by the activities of Cdk4 and Cdk6 complexed with the D-type cyclins and by cyclin E/Cdk2 (refs 1,2,3). The activities of these holoenzymes are constrained ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/36606
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  • 3
    Electronic Resource
    Electronic Resource
    Deregulation of cell growth by the K1 gene of Karposi's sarcoma-associated herpesvirus (1998)
    [s.l.] : Nature Publishing Group
    Nature medicine 4 (1998), S. 435-440 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] At a position equivalent to the gene encoding the saimiri transforming protein (STP) of herpesvirus saimiri (HVS), Kaposi's sarcoma-associated herpesvirus (KSHV) contains a distinct open reading frame called K1. Although KSHV and HVS are related members of the rhadinovirus subgroup of gamma ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0498-435
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  • 4
    Electronic Resource
    Electronic Resource
    Tumour induction with DNA of oncogenic primate herpesviruses (1978)
    [s.l.] : Nature Publishing Group
    Nature 274 (1978), S. 57-59 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We injected 18 cotton-top marmoset monkeys (Saguinus oedipus) with increasing amounts of viral DNA. Four animals developed malignant lymphomas within 60-97 d after trans-fection. The predominant type of DNA (M genomes, M DNA, molecular weight about 100,000,000) from both viruses has an extreme ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/274057a0
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  • 5
    Electronic Resource
    Electronic Resource
    Malignant lymphoma induced by partially purifiedHerpesvirus saimiri and recovery of infectious virus from tumorous lymph nodes (1972)
    Springer
    Medical microbiology and immunology 158 (1972), S. 135-146 
    Details
    ISSN: 1432-1831
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Der Gewebekulturüberstand von mitHerpesvirus saimiri (HVS) infizierten OMK-Zellen und partiell gereinigtes HVS induzierten in Marmoset Affen (Saguinus oedipus) die Entwicklung von malignen Lymphomen. Radioaktiv markiertes HVS wurde durch Sedimentation im Saccharosegradienten und anschließende Dichtezentrifugation im Kaliumtartratgradienten partiell gereinigt und in einen Affen inoculiert. Bei diesem Tier konnte infektiöses HVS von einem tumorösen Lymphknoten 2 Std nach dessen Kultivationin vitro isoliert werden. Im Gegensatz zu den Lymphocyten aus frischem peripheren Blut war eine Kokultivation der Zellen aus dem Lymphknoten für die Isolierung des Virus nicht erforderlich. Die Entwicklung vergleichsweise hoher Titer neutralisierender Antikörper in den Seren der an einem Tumor erkrankten Tiere kann als Hinweis dafür gewertet werden, daß sich das HVS in diesen Affenin vivo vermehrt.
    Notes: Summary Supernatant of OMK cells infected withHerpesvirus saimiri (HVS) and partially purified HVS were shown to induce malignant lymphoma in New World monkeys (Saguinus oedipus). Radioactively labeled HVS was partially purified by velocity sedimentation in sucrose and buoyant density centrifugation in potassium tartrate and inoculated in a monkey. Infectious HVS was isolated from a tumorous lymph node of this animal 2 h after its cultivationin vitro. In contrast to the lymphocytes from fresh peripheral blood cocultivation of the cells obtained from the lymph node was not necessary for the isolation of the virus. The development of comparatively high amounts of neutralizing antibodies against HVS in the sera of the fatally diseased monkeys is an indication for a replication of HVS in the tumor bearing animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02120479
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  • 6
    Electronic Resource
    Electronic Resource
    Human cytomegalovirus DNA in the temporal cortex of a schizophrenic patient (1988)
    Springer
    European archives of psychiatry and clinical neuroscience 238 (1988), S. 110-113 
    Details
    ISSN: 1433-8491
    Keywords: Schizophrenia ; Cytomegaloviruses ; Virus diseases ; Recombinant DNA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Using highly sensitive nucleic acids hybridization techniques, which allow the detection of 0.1–0.5 single copy gene equivalents per cell, DNA from the temporal cortex of seven definite schizophrenics, five persons with schizophrenia-like psychoses, three patients with Huntington's chorea and nine mentally normal individuals were probed with human cytomegalovirus (HCMV) DNA. A clear hybridization signal was obtained with DNA from the temporal lobe of a young schizophrenic patient, whereas DNA from the temporal cortex of controls did not hybridize to the HCMV probe. This finding is in agreement with the cytomegalovirus hypothesis of schizophrenia and hints at the possibility that viral infection of the temporal cortex may in some sporadic cases be a contributing factor to the development of schizophrenic psychoses. There is no indication, however, that infection of the central nervous system with HCMV is an aetiological factor in the great majority of schizophrenic disorders. Clearly further studies, preferably in situ hybridizations of whole brains, are needed to prove or disprove the cytomegalovirus hypothesis of schizophrenia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00452786
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