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  • 1
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Earth and Planetary Science Letters 98 (1990), S. 287-302 
    ISSN: 0012-821X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Geosciences , Physics
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1433-2965
    Keywords: Key words:Bone – Density – Gene – Mineral – Receptor – Vitamin D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract: A recent meta-analysis of 16 publications suggested that bone mineral density (BMD) is not associated with vitamin D receptor (VDR) gene polymorphism (VDRGP) at the 0.05 significance level when a study with genotyping mistakes is excluded. We wished to determine whether ‘positive’ findings supporting the BMD–VDRGP association may be explained by chance, and what factors affect the outcomes of these studies. Seventy-five articles and abstracts on the association of VDRGP with BMD and related skeletal phenotypes published before January 1997 were identified. Twenty-three of 67 (34.3%) studies on spinal BMD and 22 of 51 (43.1%) on femoral neck BMD had found a BMD–VDRGP association at p〈0.05, significantly (p= 7 × 10–14 for spinal BMD, p= 9 × 10–16 for hip BMD) higher than the expected 5% false positive rate under the null hypothesis of ‘no association’. ‘Positive’ results were more frequently observed in studies on females before the menopause than those on females after the menopause (p〈0.02) or on male and female subjects combined (p〈0.05) when skeletal phenotypes at any bone sites were considered. The ‘positive rate’ among studies was also influenced by the age range of subjects studied and by the inclusion of subjects with osteoporosis. It is concluded that: (1) BMD is associated with VDRGP with high levels of confidence and (2) non-genetic factors and genetic heterogeneity interfere with the detection of the effects of VDRGP on bone phenotypes.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Journal of optimization theory and applications 89 (1996), S. 681-712 
    ISSN: 1573-2878
    Keywords: Two-machine flowshops ; unreliable machines ; hierarchical production policy ; weak Lipschitz continuity ; constraint domain approximation ; asymptotic optimal control ; convergence rates ; error estimates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper concerns production planning in manufacturing systems with two unreliable machines in tandem. The problem is formulated as a stochastic control problem in which the objective is to minimize the expected total cost of production, inventories, and backlogs. Since the sizes of the internal and external buffers are finite, the problem is one with state constraints. As the optimal solutions to this problem are extremely difficult to obtain due to the uncertainty in machine capacities as well as the presence of state constraints, a deterministic limting problem in which the stochastic machine capacities are replaced by their mean capacities is considered instead. The weak Lipschitz property of the value functions for the original and limiting problems is introduced and proved; a constraint domain approximation approach is developed to show that the value function of the original problem converges to that of the limiting problem as the rate of change in machine states approaches infinity. Asymptotic optimal production policies for the orginal problem are constructed explicity from the near-optimal policies of the limiting problem, and the error estimate for the policies constructed is obtained. Algorithms for constructing these policies are presented.
    Type of Medium: Electronic Resource
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