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  • 1
    Electronic Resource
    Electronic Resource
    Serum alpha-fetoprotein-positive gastric carcinoid with liver metastasis (1980)
    Springer
    Virchows Archiv 387 (1980), S. 107-116 
    Details
    ISSN: 1432-2307
    Keywords: α-fetoprotein (AFP) ; Carcinoembryonic antigen (CEA) ; Carcinoid (tumor) ; Gastric cancer ; Metastatic liver tumor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The patient was a 60-year-old Japanese male. He complained of epigastralgia and right chest pain of 4 month's duration, and general malaise, nausea and vomiting of 2 month's duration. Physical examination revealed on the right third rib a tender mass with a diameter of 2 cm and hepatomegaly with a multi-nodular surface and red palms. There were no signs of carcinoid syndrome, such as cutaneous flushing. Laboratory examinations disclosed certain biochemical alterations; alkaline phosphatase 810 IU/l, γ-glutamyl transpeptidase (γ-GTP) 2090 IU/l, carcinoembryonic antigen (CEA) 23.5 ng/ml and α-fetoprotein (AFP) 6,800 ng/ml. Both HBs-Ag and HBs-Ab were negative. The patient died in a uremic state, with rapid increases of jaundice and ascites. Autopsy revealed gastric carcinoid with extensive metastases to the liver and the bone marrow. Tumor cells showed argyrophilia but not argentaffinity. Immunofluorescence specific for AFP was positive in the hepatocytes, particularly those adjacent to the metastatic tumor cells but not in the tumor cells, either primary or secondary. 79 Cases reported in Japan of serum AFP-positive malignant tumor other than hepatocullular carcinoma and certain other malignancies of germ cell origin are reviewed and discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428433
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  • 2
    Electronic Resource
    Electronic Resource
    Non-invasive thymoma with widespread blood-borne metastasis (1981)
    Springer
    Virchows Archiv 390 (1981), S. 121-126 
    Details
    ISSN: 1432-2307
    Keywords: Thymoma ; Blood-borne metastasis ; Histologic findings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A 49 year-old woman with multiple coin lesions in both lungs died three months after admission to hospital for progressive neurologic manifestations due to increasing intracranial pressure. At autopsy, neoplastic lesions were found in the anterior mediastinum, lungs, spleen, cerebrum, liver, right kidney and right ovary. Microscopically, the tumor was composed predominantly of epithelial cells which were arranged in an hemangiopericytoma-like pattern. Rosette formation was also prominent. This case was diagnosed as a thymoma with widespread blood-borne metastasis. Previous reports of metastasizing thymomas are very uncommon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443902
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Stereological analysis of Reinke's crystals in human Leydig cells (1978)
    Springer
    Virchows Archiv 380 (1978), S. 1-9 
    Details
    ISSN: 1432-2307
    Keywords: Stereology ; Reinke's crystal ; Leydig cell ; Testis ; Testosterone
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Reinke's crystals in human Leydig cells were analyzed stereologically to assess their functional role. Testicular tissues were taken from seven older men (57–82 years old) with prostatic carcinoma and also from seven younger men (26–38 y.o.) complaining of male infertility. Sections 0.5 Μm thick, stained with toluidine blue or Heidenhein's iron-hematoxylin were examined by a point-counting method and with a Particle Measurement Computor System (πMC). When the patients were grouped by age, the mean crystal volume, the number of crystals per cell, the volume of crystals per cell and the volume ratio of crystals to cell were significantly larger in the older age group than in the younger age group. In particular, the latter three variables correlated well with the age of subjects, with correlation coefficients of r=0.66–0.85. On the other hand, none of these variables had any correlation with the concentration of plasma testosterone. These results indicate that Reinke's crystals can be considered as degenerative products in cell life but not as facultative constituents for testosterone production.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00432889
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Carcinoid tumor of the uterine cervix (1984)
    Springer
    Virchows Archiv 402 (1984), S. 331-336 
    Details
    ISSN: 1432-2307
    Keywords: Carcinoid ; Uterine cervix ; Histopathology ; Ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of carcinoid tumor of the uterine cervix is reported. The patient was a 76-year-old Japanese woman with a complaint of vaginal bleeding. She was clinically diagnosed as stage IVb carcinoma of the uterine cervix. Light microscopically, the tumor was characterized by formation of solid cell nests and, in limited areas, glandular structures. The tumor cells in solid cells nests showed positive argyrophil reaction but were negative for argentaffin reaction. At the ultrastructural level, the cytoplasm of the tumor cells contain numerous neurosecretory granules, microfilaments and well-developed Golgi complexes. On the bases of histochemical and electron microscopic features of tumor cells, the tumor was diagnosed as carcinoid tumor of the uterine cervix.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00695086
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  • 5
    Electronic Resource
    Electronic Resource
    Choriocarcinomatous change with immunocytochemically HCG-positive cells in the gastric carcinoma of the males (1982)
    Springer
    Virchows Archiv 396 (1982), S. 141-153 
    Details
    ISSN: 1432-2307
    Keywords: Choriocarcinoma ; Gastric neoplasm ; Human chorionic gonadotropin (hCG) ; Pregnancy specific β-1 glycoprotein (SP-1) ; Immunocyto-chemistry ; Immunoperoxidase stain
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Gastric choriocarcinoma is a rare tumor and attracts interest because of its controversial pathogenesis. The present study reports a choriocarcinomatous change with immunocytochemically hCG-positive cells in the gastric carcinoma. The patients were males, one was 41 years old and the other 42 years old. The tumor of both cases consists of adenocarcinoma and choriocarcinoma. A sequential process of morphological transition of the adenocarcinoma to the choriocarcinoma can be traced. Indirect immunoperoxidase stain (PAP method) for human chorionic gonadotropin (hCG) demonstrates the localization of hCG in the syncytiotrophoblasts. Small number of cytotrophoblasts are weakly positive. None of the components of adenocarcinoma of both cases is positive for hCG. Human placental lactogen is not demonstrated in both cases. Stain for pregnancy specific β-1 glycoprotein is weakly positive in the adenocarcinoma of one case but not in the choriocarcinoma. In one case, the concentration of hCG was 19.9mIU/ml in the preoperative serum and decreased to 1.2mIU/ml after gastrectomy. HCG production by gastric carcinoma was discussed with regard to possible pathogenesis of gastric choriocarcinoma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431237
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    Paper (German National Licenses)
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