Library

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 112 (1990), S. 1678-1681 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Pure and applied geophysics 143 (1994), S. 633-653 
    ISSN: 1420-9136
    Keywords: Block-spring models ; chaos ; earthquake patterns
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Physics
    Notes: Abstract We analyze the effect of tectonic plate velocities in the earthquake pattern using a simple mass-spring model of the Burridge and Knopoff type with two blocks and a velocity-weakening friction law. Previous versions of the two-block model assume a steady driver during slip events (limit of zero driver velocity), which, in some cases makes necessary the introduction of artificial parameters to start the numerical integration of the equations of motion at impending slip of any block. Still maintaining the condition of zero driver velocity during slip, we shall introduce a procedure to start the numerical integration without introducing artificial parameters and this will be done by using a linearized version of the equations of motion valid for small velocities and considering nonzero driver velocity. We also introduce a four parameter model in which the driver velocity enters the equations during the whole simulation, and analyze the effect of the new parameter, the driver velocity, in the displacement and time patterns of blocks motion, directly related to earthquake statistics such as coseismic slips and average repeat times.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 3
    ISSN: 1574-6968
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract Leishmania (Leishmania) infantum is the causative agent of both the cutaneous and visceral forms of leishmaniasis in southwest Europe; the dog is the main reservoir. In order to identify the L. (L.) infantum zymodemes present in Spain, a total number of 85 Leishmania stocks isolated from dogs (31), HIV-positive patients (46) with visceral or cutaneous leishmaniasis, a patient with visceral leishmaniasis complicating renal transplantation (1) and immunocompetent patients (7) with visceral or cutaneous leishmaniasis, have been characterized by isoenzyme typing. All canine stocks were MON-1, which is the most widespread zymodeme in the Mediterranean area. In immunocompetent patients three zymodemes were found: MON-1 (2), MON-24 (2) and MON-34 (3). Nine different zymodemes were obtained in stocks from HTV co-infected patients, indicating a higher variability of L. (L.) infantum amongst them: MON-1 (in 21 stocks), MON-24 (7), MON-28 (1), MON-29 (3), MON-33 (7), MON-34 (1) and MON-183 (4). Two new zymodemes, MON-198 (1) and MON-199 (1), were described among HIV patients from Spain. The stock from the renal transplanted patient was MON-1. The exclusive presence of certain zymodemes in immunocompromised patients and their absence in typical cases of cutaneous and visceral
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 4
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical journal international 113 (1993), S. 0 
    ISSN: 1365-246X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Inspired by an earlier work by Smalley, Turcotte & Solla (1985), in this paper we consider a fault consisting of large sets of asperities with a statistical distribution of strength. It is argued that the principle of equal-load-sharing between asperities, inside a segment, is necessary to account for the stick-slip behaviour. This principle is responsible for amplifying—or damping—the effective probability for the displacement of crustal blocks. the antecedents of this idea in the seismological literature are commented on.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 6
    ISSN: 1365-3121
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Regional seismicity (i.e. that averaged over large enough areas over long enough periods of time) has a size–frequency relationship, the Gutenberg–Richter law, which differs from that found for some seismic faults, the Characteristic Earthquake relationship. But all seismicity comes in the end from active faults, so the question arises of how one seismicity pattern could emerge from the other. The recently introduced Minimalist Model of Vázquez-Prada et al. of characteristic earthquakes provides a simple representation of the seismicity originating from a single fault. Here, we show that a Characteristic Earthquake relationship together with a fractal distribution of fault lengths can accurately describe the total seismicity produced in a region. The resulting earthquake catalogue accounts for the addition of both all the characteristic and all the non-characteristic events triggered in the faults. The global accumulated size–frequency relationship strongly depends on the fault length fractal exponent and, for fractal exponents close to 2, correctly describes a Gutenberg–Richter distribution with a b exponent compatible with real seismicity.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical geology 27 (1995), S. 23-39 
    ISSN: 1573-8868
    Keywords: rock fracture ; renormalizalion-group ; percolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geosciences , Mathematics
    Notes: Abstract We reanalyzed a model introduced by T. R. Madden for the evaluation of the state of connectivity among the microcrack population existing inside crystalline rocks. The model assumes that cracks are distributed randomly in a cubic lattice with a basic occupation probability, p.Depending on the value of p, the stale of connectivity can give rise to macroscopic paths, which allow electrical conduction of the sample, or to extended crack surfaces, which would be responsible for rock failure. The position of the phase boundaries, that is, the threshold values of pfor the onset of conductivity or macroscopic fracture, are estimated by a real-space renormalizalion-group (RG) technique. By identifying all the relevant configurations of the lattice model, we have been able to provide explicit analytic formulae for the critical lines. The criterion used by Madden to “accept” the existence of microscopic linear connectivity is modified and the new consequences discussed. We analyze the limitations of simple versions of the RG technique, in particular when concerned with anisotropic spatial distributions of cracks. Finally, we emphasize the interest of acquiring experimental data, especially to test the position of the conduction thresholds.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 8
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 25 (1996), S. 143-156 
    ISSN: 0887-3585
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: The magnitude of the conformational entropy change experienced by the peptide backbone upon protein folding was investigated experimentally and by computational analysis. Experimentally, two different pairs of mutants of a 33 amino acid peptide corresponding to the leucine zipper region of GCN4 were used for high-sensitivity microcalorimetric analysis. Each pair of mutants differed only by having alanine or glycine at a specific solvent-exposed position under conditions in which the differences in stability could be attributed to differences in the conformational entropy of the unfolded state. The mutants studied were characterized by different stabilities but had identical heat capacity changes of unfolding (ΔCp), identical solvent-related entropies of unfolding (ΔSsolv), and identical enthalpies of unfolding (ΔH) at equivalent temperatures. Accordingly, the differences in stability between the different mutants could be attributed to differences in conformational entropy. The computational studies were aimed at generating the energy profile of backbone conformations as a function of the main chain dihedral angles φ and ϱ. The energy profiles permit a direct calculation of the probability distribution of different conformers and therefore of the conformational entropy of the backbone. The experimental results presented in this paper indicate that the presence of the methyl group in alanine reduces the conformational entropy of the peptide backbone by 2.46 ± 0.2 cal/K · mol with respect to that of glycine, consistent with a 3.4-fold reduction in the number of allowed conformations in the alanine-containing peptides. Similar results were obtained from the energy profiles. The computational analysis also indicates that the addition of further carbon atoms to the side chain had only a small effect as long as the side chains were unbranched at position β. A further reduction with respect to Ala of only 0.61 and 0.81 cal/K · mol in the backbone entropy was obtained for leucine and lysine, respectively. β-branching (Val) produces the largest decrease in conformational entropy (1.92 cal/K · mol less than Ala). Finally, the backbone entropy change associated with the unfolding of an α-helix is 6.51 cal/K · mol for glycine. These and previous results have allowed a complete estimation of the conformational entropy changes associated with protein folding. © 1996 Wiley-Liss, Inc.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 9
    Electronic Resource
    Electronic Resource
    Chichester : Wiley-Blackwell
    Journal of Physical Organic Chemistry 2 (1989), S. 646-652 
    ISSN: 0894-3230
    Keywords: Organic Chemistry ; Physical Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Using a series of equations connecting experimental and theoretical values, it is possible to discuss the origin of the N-methylation effect in azoles dissolved in water and dimethyl sulphoxide. The existence in the azoles studied of a linear relationship between the gas → solution transfer enthalpies and the charge on the pyrrole hydrogen atom demonstrated the fundamental importance of the loss of an active centre for solvation. For the imidazole-N-methylimidazole pair, the complete thermochemical cycle has been determined, allowing the apparent lack of an effect of N-methylation on the basicity in solution to be discussed.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
  • 10
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Proteins: Structure, Function, and Genetics 26 (1996), S. 123-133 
    ISSN: 0887-3585
    Keywords: enthalpy ; thermodynamics ; folding/unfolding ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine
    Notes: Two effects are mainly responsible for the observed enthalpy change in protein unfolding: the disruption of internal interactions within the protein molecule (van der Waals, hydrogen bonds, etc.) and the hydration of the groups that are buried in the native state and become exposed to the solvent on unfolding. In the traditional thermodynamic analysis, the effects of hydration have usually been evaluated using the thermodynamic data for the transfer of small model compounds from the gas phase to water. The contribution of internal interactions, on the other hand, are usually estimated by subtracting the hydration effects from the experimental enthalpy of unfolding. The main drawback of this approach is that the enthalpic contributions of hydration, and those due to the disruption of internal interactions, are more than one order of magnitude larger than the experimental enthalpy value. The enthalpy contributions of hydration and disruption of internal interactions have opposite signs and cancel each other almost completely resulting in a final value that is over 10 times smaller than the individual terms. For this reason, the classical approach cannot be used to accurately predict unfolding enthalpies from structure: any error in the estimation of the hydration enthalpy will be amplified by a factor of 10 or more in the estimation of the unfolding enthalpy. Recently, it has been shown that simple parametric equations that relate the enthalpy change with certain structural parameters, especially changes in solvent accessible surface areas have considerable predictive power. In this paper, we provide a physical foundation to that parametrization and in the process we present a system of equations that explicitly includes the enthalpic effects of the packing density between the different atoms within the protein molecule. Using this approach, the error in the prediction of folding/unfolding enthalpies at 60°C, the median temperature for thermal unfolding, is better than ±3% (standard deviation = 4 kcal/mol). © 1996 Wiley-Liss, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...