ISSN:
1432-1912
Keywords:
Catecholamine Storage
;
Catecholamine-Nucleotide Aggregation
;
Interaction with Intragranular Proteins
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Analytical ultracentrifugation at different sets of conditions in the temperature range between 10 and 34° C shows that mixtures of l-noradrenaline and adenosine-5′-triphosphate in the presence of Ca2+ always sediment jointly, i.e. with only one single schlieren peak together with intragranular expanded proteins obtained from bovine adrenal medulla. In contrast, two schlieren peaks are obtained on addition of a globular protein, such as serum albumin, to l-noradrenaline-Ca2-adenosine-5′-triphosphate mixtures. It is concluded that aggregates of l-noradrenaline and adenosine-5′-triphosphate interact with the expanded proteins present in the catecholamine storage organelles.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00505667
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