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  • 1
    Electronic Resource
    Electronic Resource
    Surface changes of gold electrodes produced by periodic potential treatments in hydrofluoric acid solutions (1989)
    s.l. : American Chemical Society
    Langmuir 5 (1989), S. 165-170 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00085a031
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  • 2
    Electronic Resource
    Electronic Resource
    Ultrastructure of regions containing homologous loci in polytene chromosomes of Drosophila melanogaster and Drosophila subobscura (1998)
    Springer
    Chromosoma 107 (1998), S. 113-126 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract.  We have used a new approach involving in situ hybridisation and electron microscopy to establish ultrastructural homologies between polytene chromosome regions of Drosophila melanogaster and Drosophila subobscura. Twelve probes were chosen to cover all the chromosomal elements: the myospheroid gene, the collagen type IV gene, the collagen-like gene, the w26 homeobox gene, the β3 tubulin gene, the kinesin heavy chain gene, the tryptophan hydrolase gene, the Hsp82, Hsp22–26 and Hsp23–28, Hsp68, Hsp70 genes and the β unit of the F0–F1 ATPase gene. Most of these loci were previously undescribed in D. subobscura and imprecisely located in D. melanogaster. We have demonstrated here, by an ultrastructural analysis of each chromosomal region, that homologous genetic loci tend to show a similar ultrastructure in the two species. With a few exceptions, the structural homology extends to the chromosomal regions surrounding the loci. In some cases, however, no structurally recognisable homology can be seen either in the locus or in its flanking regions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004120050287
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  • 3
    Electronic Resource
    Electronic Resource
    On the computational efficiency and implementation of block-iterative algorithms for nonlinear coupled problems (1996)
    Bradford : Emerald
    Engineering computations 13 (1996), S. 4-30 
    Details
    ISSN: 0264-4401
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology
    Notes: Outlines a general methodology for the solution of the system of algebraic equations arising from the discretization of the field equations governing coupled problems. Considers that this discrete problem is obtained from the finite element discretization in space and the finite difference discretization in time. Aims to preserve software modularity, to be able to use existing single field codes to solve more complex problems, and to exploit computer resources optimally, emulating parallel processing. To this end, deals with two well-known coupled problems of computational mechanics - the fluid-structure interaction problem and thermally-driven flows of incompressible fluids. Demonstrates the possibility of coupling the block-iterative loop with the nonlinearity of the problems through numerical experiments which suggest that even a mild nonlinearity drives the convergence rate of the complete iterative scheme, at least for the two problems considered here. Discusses the implementation of this alternative to the direct coupled solution, stating advantages and disadvantages. Explains also the need for online synchronized communication between the different codes used as is the description of the master code which will control the overall algorithm.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/02644409610128382
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  • 4
    Electronic Resource
    Electronic Resource
    Sperm basic nuclear proteins in the bivalve mollusc Mesodesma donacium: Characterization and comparison with histone-like and protamine-like proteins of other molluscs
    Amsterdam : Elsevier
    Comparative Biochemistry and Physiology -- Part B: Biochemistry and 102 (1992), S. 947-952 
    Details
    ISSN: 0305-0491
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0305-0491(92)90107-3
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  • 5
    Electronic Resource
    Electronic Resource
    Ca2+ and Reactive Oxygen Species in Staurosporine-Induced Neuronal Apoptosis (1997)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 68 (1997), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Staurosporine (0.03–0.5 µM) induced a dose-dependent, apoptotic degeneration in cultured rat hippocampal neurons that was sensitive to 24-h pretreatments with the protein synthesis inhibitor cycloheximide (1 µM) or the cell cycle inhibitor mimosine (100 µM). To investigate the role of Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis, we overexpressed calbindin D28K, a Ca2+ binding protein, and Cu/Zn superoxide dismutase, an antioxidative enzyme, in the hippocampal neurons using adenovirus-mediated gene transfer. Infection of the cultures with the recombinant adenoviruses (100 multiplicity of infection) resulted in a stable expression of the respective proteins assessed 48 h later. Overexpression of both calbindin D28K and Cu/Zn superoxide dismutase significantly reduced staurosporine neurotoxicity compared with control cultures infected with a β-galactosidase overexpressing adenovirus. Staurosporine-induced neuronal apoptosis was also significantly reduced when the culture medium was supplemented with 10 or 30 mM K+, suggesting that Ca2+ influx via voltage-sensitive Ca2+ channels reduces this apoptotic cell death. In contrast, neither the glutamate receptor agonist NMDA (1–10 µM) nor the NMDA receptor antagonist dizocilpine (MK-801; 1 µM) was able to reduce staurosporine neurotoxicity. Cultures treated with the antioxidants U-74500A (1–10 µM) and N-acetylcysteine (100 µM) also demonstrated reduced staurosporine neurotoxicity. These results suggest a fundamental role for both Ca2+ and reactive oxygen species in staurosporine-induced neuronal apoptosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.1997.68041679.x
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  • 6
    Electronic Resource
    Electronic Resource
    Invasion of thehobo transposable element studied byin situ hybridization on polytene chromosomes ofDrosophila melanogaster (1994)
    Springer
    Genetica 93 (1994), S. 91-100 
    Details
    ISSN: 1573-6857
    Keywords: Drosophila melanogaster ; injected strains ; hobo transposable element ; in situ hybridization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The invasion kinetics ofhobo transposable element in theDrosophila melanogaster genome was studied byin situ hybridization on the polytene chromosomes. Six independent lines ofDrosophila melanogaster flies that had been previously transformed by microinjection of the pHFL1 plasmid containing a completehobo element were followed over 50 generations. We observed thathobo elements were scattered on each of the chromosome arms, with more insertion sites on the 3R arm. The total number of insertion sites remains quite small, between four and six, at generation 52. On the 2R arm, a short inversion appeared once at generation 52. Most of the integration sites reported here were already described for several transposons but some of them appear to be hotspots forhobo elements.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01435242
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  • 7
    Electronic Resource
    Electronic Resource
    The evolutionary genetics of thehobo transposable element in theDrosophila melanogaster complex (1994)
    Springer
    Genetica 93 (1994), S. 79-90 
    Details
    ISSN: 1573-6857
    Keywords: evolution ; transposable element ; hobo ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Hobo elements are a family of transposable elements found inDrosophila melanogaster and its three sibling species:D. simulans, D. mauritiana andD. sechellia. Studies inD. melanogaster have shown thathobo may be mobilized, and that the genetic effects of such mobilizations included the general features of hybrid dysgenesis: mutations, chromosomal rearrangements and gonadal dysgenis in F1 individuals. At the evolutionary level somehobo-hybridizing sequences have also been found in the other members of themelanogaster subgroup and in many members of the relatedmontium subgroup. Surveys of older collected strains ofD. melanogaster suggest that completehobo elements were absent prior to 50 years ago and that they have recently been introduced into this species by horizontal transfer. In this paper we review our findings and those of others, in order to precisely describe the geographical distribution and the evolutionary history ofhobo in theD. melanogaster complex. Studies of the DNA sequences reveal a different level of divergence between the groupD. melanogaster, D. simulans andD. mauritiana and the fourth speciesD. sechellia. The hypothesis of multiple transfers in the recent past into theD. melanogaster complex from a common outside source is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01435241
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  • 8
    Electronic Resource
    Electronic Resource
    Treatment of schizophrenic disorder, paranoid type, with intramuscular recombinant alpha-2b interferon (1993)
    Springer
    Biotherapy 7 (1993), S. 27-37 
    Details
    ISSN: 1573-8280
    Keywords: Interferon alpha ; Schizophrenia ; intramuscular
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Twenty patients meeting DSM-III criteria for Schizophrenic Disorder, Paranoid Type were studied. After a 30 day drug-free period the patients were randomized in two groups. During a year, patients in Group 1 received intramuscular injections of a placebo while Group 2 received recombinant IFN alpha-2b. Both groups took anti-psychotic medication (APM) as needed on an individual basis, depending on their psychiatric symptomatology. Double blind evaluations, were performed at the beginning and at the end of the trial, using the Brief Psychiatric Rating Scale (BPRS) and the Reyes Scale for Social Evolution (RSSE). Information about relapses was gathered such as months without relapse, number and duration of the relapses and maximum dosages of APM given for relapse control. The statistical analysis of the results was performed with a matched pairs sign or Student's t tests for comparisons of each group before and after treatment. Groups were compared between them using the Fisher's exact test for frequencies and Student's t test for continuous variables. In Group 1: only one patient improved on the BPRS score; two had improved ratings on the RSSE; 2 patients got worse; and there were no changes in the rest of the group; three patients had no relapses and one increased in relapse frequency. These changes were not significant. The rate of relapses per year and their duration were not significantly modified in Group 1. The maximum dose of APM required for their relapse control was larger than before treatment although not significantly. All these patients required continuous APM. In Group 2 (IFN treated): 6 patients had improved BPRS scores (N=6, K=6, p〈0.01) and 5 improved their RSSE scores (n=5, K=5, p〈0.05). In 5 patients there were no relapses on their frequency decreased. There was significant reduction in the duration of the relapses (37.8±14.6 to 20.7±12.5 days; t=4.83; d.f.=9; p=0.0009) after treatment. Only 3 patients in Group 2 needed continuous APM after a relapse and the maximum dose required for control was significantly less (1281±527 to 687±552 chlorpromazine-equivalent mg. per day; t=5.56, p 〈 0.001). Comparisons between groups showed advantage for the IFN treated group in the BPRS change, proportion of patients needing continuous APM and integral evaluation. These results indicate that alpha IFN may be useful in the treatment of Schizophrenic Disorder, Paranoid Type.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01878151
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  • 9
    Electronic Resource
    Electronic Resource
    Thermo-hydro-mechanical analysis of partially saturated porous materials (1996)
    Bradford : Emerald
    Engineering computations 13 (1996), S. 113-143 
    Details
    ISSN: 0264-4401
    Source: Emerald Fulltext Archive Database 1994-2005
    Topics: Technology
    Notes: Presents a fully coupled numerical model to simulate the slow transient phenomena involving heat and mass transfer in deforming partially saturated porous materials. Makes use of the modified effective stress concept together with the capillary pressure relationship. Examines phase changes (evaporation-condensation(, heat transfer through conduction and convection, as well as latent heat transfer. The governing equations in terms of gas pressure, capillary pressure, temperature and displacements are coupled non-linear differential equations and are discretized by the finite element method in space and by finite differences in the time domain. The model is further validated with respect to a documented experiment on partially saturated soil behaviour, and the effects of two-phase flow, as compared to the one-phase flow solution, are analysed. Two other examples involving drying of a concrete wall and thermoelastic consolidation of partially saturated clay demonstrate the importance of proper physical modelling and of appropriate choice of the boundary conditions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1108/02644409610151584
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  • 10
    Electronic Resource
    Electronic Resource
    Peroxidase and gamma-glutamyl transpeptidase activities duringEimeria nieschulzi (Apicomplexa) and/orNippostrongylus brasiliensis (Nematoda) infections in the rat (1986)
    Springer
    Cellular and molecular life sciences 42 (1986), S. 49-50 
    Details
    ISSN: 1420-9071
    Keywords: Eimeria nieschulzi ; Nippostrongylus brasiliensis ; gamma-glutamyl transpeptidase ; peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Results suggest that malabsorption of amino acids which occurs duringEimeria nieschulzi andNippostrongylus brasiliensis infections in rats is not due to impairment by intestinal inflammation of gamma-glutamyl transpeptidase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01975890
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