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  • 1
    Electronic Resource
    Electronic Resource
    Infantile neuroaxonal dystrophy or Seitelberger's disease (1974)
    Springer
    Acta neuropathologica 28 (1974), S. 261-267 
    Details
    ISSN: 1432-0533
    Keywords: Neuroaxonal Dystrophy ; Infantile Autonomi Nervous System ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The autonomic nervous system is studied by electron microscopy for the first time in two siblings born of North African consanguineous parents and affected by infantile neuroaxonal dystrophy. The changes already reported in dystrophic axons of the central and peripheral nervous system, are seen in the myenteric plexus of rectum mucosa. The authors stress the diffuse involvement of the nervous tissue in this degenerative disorder of still unknown nature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00719031
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  • 2
    Electronic Resource
    Electronic Resource
    Maladie de Niemann-Pick type “C” de Crocker (1976)
    Springer
    Acta neuropathologica 34 (1976), S. 65-76 
    Details
    ISSN: 1432-0533
    Keywords: Niemann-Pick disease, Crocker's type C ; Ultrastructural study of a case
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report electron microscopic findings in brain, bone marrow and liver biopsies in a case of juvenile Niemann-Pick disease (Crocker's type C). The diagnosis was supported by clinical data increase of blood sphingomyelin and vacuolated histiocytes in bone marrow and liver. Neurons and glial cells were filled with two types of cytosomes: classical multilamellar bodies and unusual pleiomorphic bodies. The latter type probably showed some lipofuscinic component. The relationship between type C and classical Niemann-Pick disease is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684945
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  • 3
    Electronic Resource
    Electronic Resource
    Esthésioneurocytome olfactif (1976)
    Springer
    Acta neuropathologica 35 (1976), S. 139-150 
    Details
    ISSN: 1432-0533
    Keywords: Electron microscopy ; Olfactory esthesioneurocytoma ; Neurosecretory granules ; Microtubules ; Dystrophic axons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary One case of malignant tumour of the left nasal cavity is reported in a woman 56 year old, affected by the disease 24 years. Numerous recurrences appeared and various histological diagnoses were performed. At the last surgery, the tumour invaded the ethmoïd and was a typical olfactory esthesio-neurocytoma. By electron microscopy, mature ganglion cells with dense cored vesicles (neurosecretory granules) were densely packed. Neuritic processes with microtubules were rarely normal in size and their content was most often abnormal; furthermore dystrophic axons were noted in great number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690560
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Ultrastructural study of three cases of encephalopathy with hypsarrhythmia (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 311-314 
    Details
    ISSN: 1432-0533
    Keywords: Encephalopathy with hypsarrhythmia ; Spongiform changes of cerebral cortex ; Cell fusion index
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report a morphological study of three cases of infantile hypsarrhythmia. The cerebral cortex lesions consisted of a diffuse neuropile microspongiosis, corresponding ultrastructurally to vacuolized and enlarged neuronal processes, particularly postsynaptic bags. The morphological aspects and the high cell fusion index in one case resemble those described in transmissible subacute spongiform encephalopathies.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691265
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  • 5
    Electronic Resource
    Electronic Resource
    Infratentorial ependymomas of childhood (1991)
    Springer
    Acta neuropathologica 82 (1991), S. 208-216 
    Details
    ISSN: 1432-0533
    Keywords: Infratentorial ependymomas ; Childhood ; Immunohistochemistry ; AgNORs ; Prognosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We have examined pathological criteria in 16 cases of infratentorial ependymomas of childhood using a conventional histological approach, with immunohistochemistry and silver nucleolar organizer region staining (AgNORs). We have found that some of these criteria are of prognostic value. The following histological features were evaluated in each case: cellular density, cellular or nuclear pleiomorphism, mitosis, focal necrosis, endothelial proliferation and complete loss of differentiation. The expression of the following antigens was also studied: epithelial membrane antigen (EMA), human natural killer (HNK1), glial fibrillary acidic protein (GFAP) and vimentin. Only three histological criteria have been retained as indicative of bad prognosis, i.e., high mitotic index, a large amount of necrosis and complete loss of differentiation. These criteria distinguish ependymomas from anaplastic ependymomas. GFAP was expressed in all tumors while other antigens were more variable. In addition tumors expressing large amounts of GFAP were statistically associated with a better prognosis. Increased vimentin expression associated with a decrease of GFAP immunoreactivity correlated with anaplasia and short survival. EMA was not directly correlated with postoperative survival but may be considered as a further prognostic factor. Finally AgNORs values were not statistically correlated with postoperative survival.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00294447
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  • 6
    Electronic Resource
    Electronic Resource
    Specific ultrastructural markers of human pinealomas (1983)
    Springer
    Acta neuropathologica 62 (1983), S. 31-40 
    Details
    ISSN: 1432-0533
    Keywords: Human pinealomas ; Ultrastructure ; Specific markers ; Pinealocyte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary An ultrastructural study of four pinealomas was carried out to precise eventual specific markers. Dark and clear cells joined with zonulae adherents, extensive and pleiomorphous processes, a complex vacuolar system, and characteristic organelles (lysosome-like structures, clear and dense-core vesicles, vesicle-crowned rodlets and related structures, microtubular sheaves and centriolar derivatives, membranous whorls, fibrous bodies, microtubules, heterogeneous cytoplasmic inclusions) offered a typical pattern. No correlation could be made between the histological and ultrastructural features. The authors stress the ultrastructural similarities between the human tumor cells and the mammalian pineal cells. Pinealomas appeared as a morphological entity distinct from neuronal and astrocytic tumors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00684917
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  • 7
    Electronic Resource
    Electronic Resource
    Giant axonal neuropathy (1977)
    Springer
    Acta neuropathologica 39 (1977), S. 261-269 
    Details
    ISSN: 1432-0533
    Keywords: Giant axons ; Neuropathy ; Neurofilaments ; Microfilaments ; Sympathetic neurons
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A case of giant axonal neuropathy in a 8 years old child is reported by light and electron microscopy. Clinically, this case is strikingly similar to the rare previous reports and characterized by a distal neuropathy, CNS symptoms and tightly curled hair. Giant axons were found in the sural nerve but had been absent at the onset of the illness. An increase in the number of neurofilaments was found in the axons and neurons of the myenteric plexus. The number of microfilaments was also increased in various types of cells namely Schwann and endothelial cells and fibroblasts: This suggests that the metabolic disorder, probably inborn and genetic, does not only affect the nervous system.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691706
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  • 8
    Electronic Resource
    Electronic Resource
    Esthesioneuroepithelioma, a true neurosensorial tumor (1981)
    Springer
    Acta neuropathologica 55 (1981), S. 77-80 
    Details
    ISSN: 1432-0533
    Keywords: Esthesioneuroepithelioma ; Olfactory neuroblastoma ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A rare case of esthesioneuroepithelioma infiltrating the right frontal lobe is reported in a 41-year-old man. This tumor composed of compact lobules with tubular arrangements, ultrastructurally showed two different cell types, both devoid of neurosecretory granules and reminiscent of neurons and sustentacular cells of the olfactory epithelium. These features are distinguished from those generally observed in olfactory neuroblastomas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00691536
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  • 9
    Electronic Resource
    Electronic Resource
    Central neurocytoma (1982)
    Springer
    Acta neuropathologica 56 (1982), S. 151-156 
    Details
    ISSN: 1432-0533
    Keywords: Central neuronal tumor ; Third ventricle tumor ; Synapses ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The authors report two cases of a rare tumor in adults which were inserted on the fornix and caused a frontal syndrome. By light microscopy, the tumors, highly calcified, were composed of small clear cells forming dense areas in a patchy fibrillary stroma. Electron microscopy revealed a striking neuronal differentiation with numerous synapses. These tumors, for which the term neurocytomas was proposed, were compared with the other CNS neuronal tumors described in the literature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690587
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  • 10
    Electronic Resource
    Electronic Resource
    Herpes simplex virus antigen detection in human acute encephalitis: (1985)
    Springer
    Acta neuropathologica 68 (1985), S. 245-252 
    Details
    ISSN: 1432-0533
    Keywords: Immunoperoxidase ; Herpes virus ; encephalitis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Autopsy specimens from six patients with clinically diagnosed herpes simplex virus (HSV) encephalitis were studied. Since immunocytochemistry has been reported to be more reliable and successful method to identify HSV as the etiologic agent, antitype 1 HSV (HSV1) and antitype 2 HSV (HSV2) and the avidin-biotin-peroxidase complex (ABC) method were applied to brain paraffin sections. Positive immunostaining was observed in front-orbital, mediobasal temporal lobes, cingulate gyrus, and insula. The staining was bilateral but predominant on one side. In neurons, the cytoplasmic staining was prominent in perikarya and processes, less often observed in nuclei, rarely seen in nuclear inclusions. The positive staining was intense in oligodendrocytes and macrophages, in both nuclei and cytoplasm. In two cases astrocytic processes were stained strongly. Perivascular lymphocytes were always negative. Positive reactions were obtained with both anti-HSV1 and anti-HSV2 but weaker with anti-HSV2. This results suggests that, because of its high sensitivity, ABC method permits viral antigen detection not feasible with other methods. However, this method lacks of accuracy for HSV typing mainly because of probable antigens changes resulting from tissue processing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00690202
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