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  • 1
    Electronic Resource
    Electronic Resource
    A novel ex vivo model for investigation of fluid displacements in bone after endoprosthesis implantation (1999)
    Springer
    Journal of materials science 10 (1999), S. 801-806 
    Details
    ISSN: 1573-4838
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine , Technology
    Notes: Abstract Tissue perfusion and mass transport in the vicinity of implant surfaces prior to integration or bonding may play a crucial role in modulating cellular activities associated with bone remodeling, in particular, at early stages of the integration process. Furthermore, fluid displacements have been postulated to transduct mechanical stress signals to bone cells via loading-dependent flow of interstitial fluid through the lacunocanalicular network of bone. Thus, an understanding and new possibilities for influencing these processes may be of great importance for implant success. An ex vivo model was developed and validated for investigation of fluid displacements in bone after endoprosthesis implantation. This model serves to explicate the effects of surgical intervention as well as mechanical loading of the implant–bone construct on load-induced fluid flow in the vicinity of the implant. Using this model, we intend to quantify perfusion and extravascular flow dynamics in the vicinity of implants and define optimal conditions for enhancing molecular transport of osteotropic agents from the implant surface to apposing bone as well as from the blood supply to the implant surface. Furthermore, the elucidation of main transport pathways may help in understanding the distribution of wear particles in bone surrounding implant, a process which has been postulated to cause osteolysis and implant loosening.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008919521056
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    New developments in the application of biodegradable implants (1997)
    Springer
    Der Orthopäde 26 (1997), S. 489-497 
    Details
    ISSN: 1433-0431
    Keywords: Key words Biodegradation ; Polylactide ; Medial ankle fracture ; Distal radius fracture ; Radial head fracture ; Schlüsselwörter Biodegradation • Polylactid • Innenknöchelfraktur • Radiusfraktur • Radiusköpfchenfraktur
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Biodegradable Implantate bieten gegenüber metallischen Implantaten Vor- und Nachteile. Zahlreiche Anwendungsideen stellen sich dar. Darunter ist der Fixationsstift für gering belastete osteochondrale Fragmente am gründlichsten untersucht. Die primäre Festigkeit für Anwendungen am distalen Radius wurde vergleichbar zu herkömmlichen Implantaten wie der 1,8-mm-Kirschner-Draht gemessen. Eine prospektiv randomisierte Studie mit 183 Radiusköpfchenfrakturen zeigte gleichwertige Ergebnisse bei Metall und Polymer und insbesondre keine erhöhte Komplikationsrate für die Stifte aus Polylactid (Polypin®). Für diese Indikation und vergleichbare Lokalisationen ist eine Anwendung zu empfehlen. Die Gesamtbehandlungskosten können damit gesenkt werden, auch wenn das einzelne Implantat teurer ist. Hochfeste Polylactidschrauben haben in einer klinischen Langzeitstudie extrem lange Resorptionszeiten von 5–7 Jahren erbracht.
    Notes: Summary The application of biodegradable implants is combined with advantages and disadvan- tages. They offer a great deal of innovative ideas. Best evaluation has been done with pins for the fixation of low loaded osteochondral fractures. When using 2,7 mm Polypin® primary mechanical stabilility of distal radius fractures is comparable with the fixation by 1,8 mm K-wires. A prospective and randomised study with two years follow up, including 183 radial head fractures, showed no significant difference in results and complications in metal and polyactide implants. For this localisation and other comparable indications the implant can be recommended. Despite the more extensive degradable device overall costs can be reduced with the polymer implant. Orien- truded polyactide screws showed good clinical results, newetheless resorption was extremely late within 5 to 7 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00003404
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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