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  • 1
    Electronic Resource
    Electronic Resource
    Ethyl-(r)-(4-methylphenylsulfinyl)-n-methoxy acetimidate a useful chiral acetate equivalent in aldol type condensations
    Amsterdam : Elsevier
    Tetrahedron 40 (1984), S. 3769-3775 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0040-4020(01)88806-2
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  • 2
    Electronic Resource
    Electronic Resource
    Early weaning trials of sea bass (Dicentrarchus labrax L.) using different artificial diets
    Amsterdam : Elsevier
    Aquaculture 124 (1994), S. 283-284 
    Details
    ISSN: 0044-8486
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0044-8486(94)90391-3
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  • 3
    Electronic Resource
    Electronic Resource
    Ethyl-(r)-(4-methylphenylsulfinyl)-n-methoxy acetimidate a useful chiral acetate equivalent in aldol type condensations
    Amsterdam : Elsevier
    Tetrahedron 40 (1984), S. 3769-3775 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0040-4020(01)88806-2
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    Ethyl-(r)-(4-methylphenylsulfinyl)-n-methoxy acetimidate a useful chiral acetate equivalent in aldol type condensations
    Amsterdam : Elsevier
    Tetrahedron 40 (1984), S. 3769-3775 
    Details
    ISSN: 0040-4020
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0040-4020(01)88806-2
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    Paper (German National Licenses)
    Fulltext
  • 5
    Electronic Resource
    Electronic Resource
    Influence of stocking density of European eel (Anguilla anguilla, L.) elvers on sex differentiation and zootechnical performances (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of applied ichthyology 13 (1997), S. 0 
    Details
    ISSN: 1439-0426
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Survival rate, sex ratio and zootechnical performances were evaluated on 168 kg of Anguilla anguilla elvers (0.45 g) weaned into three groups (A1, A2, A3) at initial densities of 800, 1600 and 3200 g m−3, respectively. In order not to modify the sex ratio, animals weaned at the different densities were maintained separately during the trials, and no size grading was performed at the fattening phase.Final mean weight achieved by females belonging to the different groups showed no statistically significant differences; weight of males was higher (P 〈 0.05) in A1 than in A3 where a higher percentage of males was observed. Sex ratio of eels was different among the groups, with a higher percentage of males in A3 (96%) than in A2 (78%) or in A1 (69%). This finding testifies to a sex differentiation strongly affected by pre-fattening stocking density of elvers. Final load showed an increase in males corresponding to a significantly reduced biomass between A1 and A2 (10.97 and 10.24 kg m−3) and A3 (8.44 kg m−3). Final survival rate ranged from 87% (A1) to 90% (A3). As to food conversion, a better rate was found in A1 (1.9:1) compared to A2 (2.1:1) and A3 (2.3:1) eels.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0426.1997.tb00112.x
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  • 6
    Electronic Resource
    Electronic Resource
    Absence of Correlation Between BMP-4 Polymorphism and Postmenopausal Osteoporosis in Italian Women (2000)
    Springer
    Calcified tissue international 67 (2000), S. 93-94 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Osteoporosis — BMP-4 — Genetic association — SNP.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Several studies have demonstrated that bone has the power of regeneration and repair. BMPs (bone morphogenetic proteins) are involved in the determination of osteoblast phenotype and bone turnover, therefore genes coding for these proteins, like BMP-4, could be considered potential candidate genes for osteoporosis. We investigated the association of BMP-4 gene polymorphism with osteoporosis in a cohort of 72 osteoporotic, postmenopausal women and 82 unrelated controls. We failed to detect any significant association between this genetic marker and the disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s00223001103
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  • 7
    Electronic Resource
    Electronic Resource
    Vitamin D Receptor Genotypes and Intestinal Calcium Absorption in Postmenopausal Women (1997)
    Springer
    Calcified tissue international 61 (1997), S. 460-463 
    Details
    ISSN: 1432-0827
    Keywords: Key words: VDR genotypes — Intestinal Ca absorption — Osteoporosis genetics — Strontium chloride — Postmenopausal women.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Several studies have shown that bone mass and bone turnover are genetically determined. This genetic component is thought to be mediated in part by polymorphisms at the vitamin D receptor (VDR) locus, even though the underlying molecular mechanisms are still unknown. To evaluate a possible site of differential action of the VDR gene alleles we examined their correlation with intestinal calcium absorption in 120 Caucasian postmenopausal women (aged 61 ± 0.6 years). VDR gene polymorphisms for Apa I, Bsm I, and Taq I restriction endonucleases were assessed by Southern blotting analysis. The most common genotypes observed in our population were AaBbTt (37%), AABBtt (20%), aabbTT (15%), AabbTT (15%), and AABbTt (9%). Although there was some evidence of 13% higher lumbar BMD values in aabbTT genotype with respect to AABBtt genotype, this difference of approximately 0.1 g/cm2 did not reach statistical significance, possibly because of the limited number of observations. On the contrary, no relationship was found between genotypes and femoral neck BMD values. Intestinal calcium absorption was significantly lower in BB and tt genotypes than, in bb and TT genotypes, respectively, and in AABBtt genotype than in either aabbTT or AaBbTt genotypes (P= 0.0015 ANOVA). No significant differences in intact PTH, alkaline phosphatase, 25OHD3, and 1,25(OH)2D3 were found among subjects with different VDR genotypes. These results are consistent with a possible role of VDR alleles on intestinal calcium absorption.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900368
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  • 8
    Electronic Resource
    Electronic Resource
    Age-Related Decline of Bone Mass and Intestinal Calcium Absorption in Normal Males (1998)
    Springer
    Calcified tissue international 63 (1998), S. 197-201 
    Details
    ISSN: 1432-0827
    Keywords: Key words: Bone mass — Intestinal calcium absorption — Aging in men.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine , Physics
    Notes: Abstract. Although about 25% of all hip fractures occur in men, little is known about the pattern of their age-related bone loss and its main determinants. The aim of this cross-sectional study was to evaluate the age-related changes of intestinal calcium absorption, bone mass, and bone turnover in normal men. In 70 normal males (age 17–91 years), we measured spinal and forearm bone density (FBD) (by DXA), fractional intestinal calcium absorption (by oral test), serum immunoreactive parathyroid hormone (PTH), dietary calcium intake (diet records), biochemical markers of bone turnover (serum alkaline phosphatase (ALP), osteocalcin, urine calcium, creatinine, and hydroxyproline), and 1,25(OH)2D3 serum levels. Vertebral bone density (VBD) showed a modest decline before age 50 and a greater decline after age 50, whereas FBD presented a significant decrease with advancing age starting at age 40, suggesting a predominant age-related cortical bone loss. Intestinal calcium absorption (47CaFA) and serum 1,25(OH)2D3 also presented an age-related decline similar to FBD. Simple correlation analysis revealed that age was significantly related to 47CaFA (r = 0.60), calcium intake (r = 0.32), VBD and FBD (r = 0.79 and 0.63, respectively), serum 1,25(OH)2D3 (r = 0.69), and serum iPTH (r = 0.72). No significant correlation was found between age and biochemical markers of bone remodeling. Partial correlation and stepwise variable selection analyses, using 47CaFA and bone mass as dependent variables, showed that in normal males, serum 1,25(OH)2D3 and dietary calcium intake were the main contributors (64%) to 47CaFA variability, whereas only age accounted for 63% of VBD and age and dietary calcium accounted for 45% of FBD variability. These results indicate that bone loss in men accelerates after age 50 years and that among other factors, intestinal calcium malabsorption and 1,25(OH)2D3 serum levels play a role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s002239900514
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  • 9
    Electronic Resource
    Electronic Resource
    Preoperative radiotherapy for resectable cancer of the middle-distal rectum: its effect on the primary lesion as determined by endorectal ultrasound using flexible echo colonoscope (1996)
    Springer
    International journal of colorectal disease 11 (1996), S. 283-286 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé. Vingt patients porteurs d'un cancer rectal à moins de 8 cm de la marge anale ont étéétudiés. Une échographie endo-anale a été réalisée avant et après la radiothérapie préopératoire (45 Gy sur une période de 3 semaines). L'extension locale (stade de la tumeur et diamètre) a été comparée avec les résultats de l'examen histologique de la pièce opératoire obtenue par la résection antérieure (12 fois) ou l'excision rectale (8 fois). Le degré de régression tumorale (TRG) et l'état des ganglions lymphatiques ont étéévalués. Deux patients n'ont pas pu être évalués par échographie endo-anale. Deux des 18 patients restants (11%) montrent une évidence échographique de régression tumorale (14/18 uT3/4 avant radiothérapie: 12/18 uT3/4 après radiothérapie) et une diminution significative du diamètre tumoral. Le degré de régression tumorale estimé montre de façon évidente une réponse au traitement, avec une diminution de plus de 50% de la tumeur chez 33 patients (65%). Les métastases ganglionnaires mesurent moins de 5 mm de diamètre dans 45% des cas. Une évidence histo-pathologique de régression des métastases ganglionnaires a été mise en évidence chez 13 patients (28%) parmi tous ceux chez lesquels des métastases ganglionnaires avaient pu être mises en évidence. La réponse à la radiothérapie déterminée par l'échographie peut apporter des informations utiles quant à la prédiction de l'évolution et, éventuellement, dans la sélection des indications chirurgicales.
    Notes: Abstract. 20 patients with rectal cancer within 8 cm of the anal verge were studied. Endoscopic endosonography was carried out before and after pre-operative radiotherapy (45 Gy over three weeks). The local extent (tumour stage and diameter) was compared with the results of histopathological examination of the resected specimen after anterior resection [12] or total rectal excision [8]. The Tumour Regression Grade (TRG) and lymph node status were also estimated. Two patients were not evaluated endosonographically. Two (11%) of the remaining 18 patients showed ultrasound evidence of down staging (14/18 uT3/4 pre-radiotherapy: 12/18 uT3/4 after) and tumour diameter was significantly reduced. Tumour Regression Grade estimation showed evidence of response to treatment, showing regression of more than 50% in 13 (65%) of cases. Involved nodes were less than 5 mm in diameter in 45% of cases. Histopathological evidence of nodal metastatic regression was seen in 13 (28%) of all involved nodes found. The ultrasonically determined response to radiotherapy may offer useful information in predicting outcome and possibly in selecting surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s003840050063
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  • 10
    Electronic Resource
    Electronic Resource
    Double versus single stapling technique in rectal anastomosis (1992)
    Springer
    International journal of colorectal disease 7 (1992), S. 31-34 
    Details
    ISSN: 1432-1262
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Une étude rétrospective pour comparer les techniques de simple contre double suture mécanique pour les anastomoses rectales a été menée à bien sur les patients qui ont subi une intervention chirurgicale radicale de résection entre janvier 1986 et janvier 1989 à l'Institut National des Tumeurs de Milan. Chez 143 malades l'intégrité de la suture a été contrôlée à la fois pendant l'opération par insufflation d'air et après l'opération par lavements et produits hydro-solubles. Une suture mécanique unique (SMU) a été réalisée par la pince EEA chez 94 patients et une suture mécanique double (SMD) utilisant la pince EEA et la pince TA chez 49 patients. La hauteur de l'anastomose était inférieure ou égale à 10 cm de la marge anale chez 94 malades (54 SMU et 40 SMD). Chez 52 patients elle était supérieure à 10 cm (40 SMU et 12 SMS) (SMU vs SMD ns). La présence d'une déhiscence anastomotique est survenue chez 29 (20%) des patients (17 SMU et 12 MSD). Ce fait n'était en relation ni avec la hauteur de l'anastomose ni avec la technique de suture utilisée. La déhiscence était localisée à la paroi postérieure dans 79% des cas et dans 58% le calibre était de moins de 1 cm. Dans 78% des cas des symptomes cliniques étaient évident. Il n'y avait pas de différence entre les patients avec SMU ou SMD. Une chirurgie itérative (colostomie) a été nécessaire chez 6 malades (2 SMU et 4 SMD). Deux patients sont morts par complication (1 SMU, 1 SMD) ainsi le taux de mortalité était de 1,0% et de 2,0% respectivement dans chaque groupe. Il n'y avait pas de différence dans le taux d'infection et la durée d'hospitalisation dans les deux groupes. Nos résultats démontrent que les deux méthodes donnent des résultats similaires. L'utilisation d'une suture mécanique double est justifiée en théorie lorsqu'il y a une différence marquée de diamètre entre le moignon rectal et l'intestin proximal à anastomoser ou lorsque la durée d'intervention doit être impérativement courte.
    Notes: Abstract A retrospective analysis to compare the single vs double stapled technique for rectal anastomosis was carried out on patients that underwent radical surgical resection between January 1986 and January 1989 at the Istituto Nazionale Tumori of Milan. In 143 patients anastomotic integrity had been checked both intraoperatively with air insufflation and postoperatively by water soluble contrast enema. A single stapled anastomosis (SST) was performed using the EEA instrument in 94 patients, and in 49 patients a double stapled (DST) using the EEA and TA instruments was performed. The level of the anastomosis was ≤10 cm from the anal margin in 94 patients (54 SST, 40 DST). In 52 patients it was 〉 10 cm (40 SST, 12 DST) (SST vs DST ns). The presence of anastomotic dehiscence occurred in 29 (20%) patients (17 SST, 12 DST). This was not related either to the anastomotic site or to the suture technique used. The dehiscence was located on the posterior wall in 79% of cases and in 58% the size was less than 1 cm. In 78 % clinical symptoms were evident. There was no difference between SST and DST patients. Further surgery (colostomy) was necessary in six patients (2 SST, 4 DST). Two patients died through complications (1 SST, 1 DST); making an overall mortality rate of 1.0% and 2.0% in each group. There was no difference in infection rate and length of postoperative stay in the two groups. Our data demonstrate that both methods give similar results. The use of DST is theoretically advisable when there is marked discrepancy in the diameter of the rectal stump and proximal bowel to be anastomised or where a short operation is imperative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01647658
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