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  • 1
    Electronic Resource
    Electronic Resource
    Pulsatile glucagon has greater hyperglycaemic, lipolytic and ketogenic effects than continuous hormone delivery in man: effect of age (1990)
    Springer
    Diabetologia 33 (1990), S. 272-277 
    Details
    ISSN: 1432-0428
    Keywords: Glucagon ; glycerol ; β-hydroxybutyrate ; ketogenesis ; lipolysis ; non esterified fatty acids ; pulsatility
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The present study aimed at investigating the hyperglycaemic, lipolytic and ketogenic effects of small doses of glucagon delivered continuously or in a pulsatile manner. The study was performed in eight healthy young volunteers (24.2±1.2 years) and in eight healthy aged subjects (69.4±2.0 years). In all the subjects, endogenous pancreatic hormone secretion was inhibited by somatostatin and only glucagon was replaced. Consequently, the effects of pulsatile and continuous glucagon delivery were studied in conditions of progressive somatostatin-induced insulin deficiency. In both the young and the aged subjects, pulsatile glucagon delivery resulted in increases in plasma glucose, non-esterified fatty acid, glycerol and β-hydroxybutyrate levels greater than those observed when the same amount of glucagon was delivered in a continuous manner. The net increases in plasma glucose, glycerol and non-esterified fatty acid levels were similar between the young and the aged subjects when glucagon was infused continuously; in contrast, the rise in plasma β-hydroxybutyrate in the aged was only about half that observed in the young subjects. Surprisingly, when glucagon was infused in a pulsatile manner, the rises in plasma glycerol, non-esterified fatty acid and β-hydroxybutyrate levels were all significantly smaller in the aged subjects, while no significant differences were observed in the blood glucose responses. We conclude that, in the presence of somatostatin-induced insulin deficiency, pulsatile glucagon exerts greater effects on blood glucose, plasma non-esterified fatty acid, glycerol and β-hydroxybutyrate levels than its continuous delivery. In the elderly, the lipolytic and ketogenic, but not the hyperglycaemic, responses to pulsatile glucagon are significantly reduced.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00403320
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  • 2
    Electronic Resource
    Electronic Resource
    Impairment of insulin secretion in man by nifedipine (1980)
    Springer
    European journal of clinical pharmacology 18 (1980), S. 395-398 
    Details
    ISSN: 1432-1041
    Keywords: insulin ; nifedipine ; glucose ; oral glucose tolerance ; chemical diabetes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of nifedipine, a calcium antagonist, on carbohydrate metabolism and insulin secretion was evaluated in patients who required treatment with this drug. 20 subjects underwent two oral glucose tolerance tests (100 g), one under basal conditions, and the other after ten days of treatment with nifedipine 30 mg/day by mouth, in three divided doses. 10 subjects had normal glucose tolerance; in them nifedipine administration reduced the insulin response to oral glucose in the first 60 min, but improved glucose tolerance. The other 10 subjects had impaired glucose tolerance and nifedipine treatment resulted in a further reduction both of insulin secretion and glucose tolerance. No such effects were seen in the placebo (weight- and disease-matched) group. The mechanism by which nifedipine influences carbohydrate metabolism and insulin secretion is discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636791
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  • 3
    Electronic Resource
    Electronic Resource
    Riesenzelltumore (Osteoklastome) der Sellagegend (1968)
    Springer
    Acta neurochirurgica 19 (1968), S. 183-197 
    Details
    ISSN: 0942-0940
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary Based on three personal cases and the report in the literature, the clinical characteristics of the giant-celled tumours (osteoclastomas) of the sella region are described. The first stage of the disease is characterized by transient disturbances of vision. The second stage is marked by encroachment on the visual fields and by limitation of eye movements. In the third stage multiple symptoms appear as the result of an increase in the tumour mass. Radical surgery and complete cure are possible in the first stage, doubtful in the second, and quite impossible in the third stage.
    Abstract: Résumé A partir de 3 cas personnels, et des publications de la littérature, les caractéristiques cliniques des tumeurs à cellules géantes (osteoclastomes) de la région sellaire sont décrites. La première phase de la maladie est caractérisée par une atteinte transitoire de la vision. La seconde phase est marquée par une encoche du champ visuel et par une limitation des mouvements oculaires. Dans la troisième phase des symptômes multiples apparaissent comme étant le résultat d'une augmentation de la masse tumorale. La chirurgie générale et la cure complète sont possibles pendant le premier stade, plus douteux pendant le second, et tout à fait impossible eu troisième stade.
    Notes: Zusammenfassung Auf Grund von 3 eigenen Fällen und der Literaturangaben werden die klinischen Eigenschaften der Riesenzelltumoren (Osteoklastome) der Sellagegend dargelegt. Das erste Krankheitsstadium ist durch vorübergehende Sehstörungen gekennzeichnet, das zweite Stadium durch Gesichtsfeldeinengungen und durch Einschränkungen der Augenbewegungen. Im dritten Stadium tritt im Zusammenhang mit dem Tumorwachstum eine vielfältige Symptomatologie auf. Die Radikaloperation und endgültige Heilung sind im ersten Stadium möglich, im zweiten zweifelhaft, im dritten unmöglich.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01402260
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  • 4
    Electronic Resource
    Electronic Resource
    Simultaneous radioenzymatic determination of phenylethylamine, phenylethanolamine, tyramine and octopamine in plasma of patients with hepatic encephalopathy
    Amsterdam : Elsevier
    Clinical Biochemistry 14 (1981), S. 187-190 
    Details
    ISSN: 0009-9120
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/S0009-9120(81)91223-6
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  • 5
    Electronic Resource
    Electronic Resource
    Cloning and characterization of an ionotropic glutamate receptor subunit expressed in the squid nervous system (2003)
    Oxford, UK : Blackwell Science, Ltd
    European journal of neuroscience 17 (2003), S. 0 
    Details
    ISSN: 1460-9568
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In this paper we describe the cloning of a putative ionotropic glutamate receptor subunit, SqGluR, and its distribution in the nervous system of the squid. A full-length cDNA was assembled from a cDNA library of the stellate ganglion/giant fibre lobe complex of Loligo opalescens. The deduced amino acid sequence of the mature SqGluR displayed 44–46% amino acid identity with mammalian GluR1–GluR4 and 53% with Lym-eGluR1 from Lymnaea stagnalis. In situ hybridizations in adult squid confirmed that the SqGluR mRNA is abundant in giant fibre lobe neurons, in large, presumptive motor neurons of the stellate ganglion proper and in the supraoesophageal and optic lobes of the central nervous system. In newborn squid, SqGluR mRNA expression was detected throughout the nervous system but not elsewhere. A synthetic peptide corresponding to the last 15 amino acids of the SqGluR C-terminus was used to generate polyclonal antibodies, which were used for immunoblot analysis to demonstrate widespread expression in the squid central and peripheral nervous systems. Injection of the synthetic peptide into the postsynaptic side of the giant synapse inhibited synaptic transmission.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1460-9568.2003.02680.x
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  • 6
    Electronic Resource
    Electronic Resource
    Unfavourable effects of colchicine in combination with interferon-α in the treatment of chronic hepatitis C (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The prognosis of chronic hepatitis depends on the progression of hepatic fibrosis.〈section xml:id="abs1-2"〉〈title type="main"〉Aim:To investigate whether the antifibrotic drug colchicine, in combination with interferon-α has a role in the treatment of chronic hepatitis C.〈section xml:id="abs1-3"〉〈title type="main"〉Methods:Sixty-five HCV–RNA positive patients with chronic hepatitis were randomized to receive interferon-α, 6 MU t.i.w. for 6 months followed by 3 MU t.i.w. for further 6 months, with or without the adjunct of colchicine, 1 mg o.d., 6 days a week, for 3 years. We report an interim analysis after the first 18 months.〈section xml:id="abs1-4"〉〈title type="main"〉Results:Thirty-four patients received interferon-α and 31 received interferon-α and colchicine. The two groups were comparable for baseline data, including HCV–RNA levels, genotypes and histological grading/staging. Drop-outs and side-effects were similar. The proportion of patients who achieved alanine transaminase normalization or undetectable HCV–RNA at month 6 was higher in the interferon-α (68% and 47%, respectively) than in the interferon-α plus colchicine group (32% and 23%, P=0.004 and P=0.04, respectively). End-of-treatment biochemical and virological response occurred in 41% and 29% of the interferon-α and 19% and 10% of the combination group, respectively (P=0.05 and P=0.05). Sustained biochemical response occurred in 26% of the interferon-α and 6% of the interferon-α plus colchicine group (P=0.03), corresponding percentages of sustained HCV–RNA loss being 21% and 3% (P=0.04).〈section xml:id="abs1-5"〉〈title type="main"〉Conclusions:The combination of colchicine and interferon-α worsens the effectiveness of interferon-α alone in HCV chronic hepatitis. These alarming findings prompted us to interrupt the trial at this stage.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00857.x
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  • 7
    Electronic Resource
    Electronic Resource
    A randomized controlled trial of amantadine plus interferon-α2a vs. interferon-α2a alone in naive patients with chronic hepatitis C randomized according to the early virological response to interferon-α2a monotherapy (2004)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 19 (2004), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : An early virological response to interferon-α treatment is a strong predictor of sustained response, but it has never been exploited to stratify patients in clinical trials.Aim : To evaluate the efficacy of amantadine plus interferon-α compared with interferon-α alone in naive patients with chronic hepatitis C who were randomized on the basis of the early virological response to interferon-α.Methods : One hundred and eighty-one patients received recombinant interferon-α2a (3 MU three times weekly) for 2 months and 164 were evaluated for early (i.e. month 2) virological response. Hepatitis C virus (HCV) RNA-negative patients (n = 66) were randomized to receive 3 MU of interferon-α three times weekly, with or without amantadine (200 mg/day); HCV RNA-positive patients (n = 98) were randomized to receive 6 MU of interferon-α three times weekly, with or without amantadine (200 mg/day). HCV RNA-positive patients at 6 months discontinued treatment, and all others completed 12 months.Results : At month 6, HCV RNA-negative patients made up 54.2% of the interferon + amantadine group and 42.0% of the monotherapy group (P = 0.07). At month 12, HCV RNA-negative patients made up 38.5% of the interferon + amantadine group and 28.4% of the monotherapy group (N.S.). The sustained virological response rates were 21.6% and 20.9%, respectively (N.S.).Conclusion : The addition of amantadine does not enhance the sustained virological response to interferon-α in naive patients with chronic hepatitis C; however, an additive effect of amantadine occurs in the first 6 months, mainly in patients without an early response to monotherapy. Early response to interferon-α is a strong predictor of sustained virological response.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2004.01843.x
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  • 8
    Electronic Resource
    Electronic Resource
    The first level energy trigger of the L3 experiment Software and performances
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 324 (1993), S. 101-112 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(93)90969-O
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  • 9
    Electronic Resource
    Electronic Resource
    A general purpose arithmetic logic unit
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 260 (1987), S. 425-429 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(87)90111-2
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  • 10
    Electronic Resource
    Electronic Resource
    A flexible timing unit: Delay and clock generator
    Amsterdam : Elsevier
    Nuclear Instruments and Methods in Physics Research Section A: 279 (1989), S. 671-674 
    Details
    ISSN: 0168-9002
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0168-9002(89)91318-1
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