ISSN:
1420-9071
Keywords:
VIP and histamine H2 receptors
;
cimetidine
;
ranitidine
;
human fetal gastric glands
;
development
;
gastric secretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Vasoactive intestinal peptide (VIP, EC50=6.4×10−10 M) and histamine (EC50=3×10−6 M) activated the cyclic AMP generating system in gastric glands isolated from two human fetuses at 23 weeks gestation. Histamine antagonism by the H2 receptor blockers cimetidine (Ki=0.35×10−6 M) and ranitidine (ki=0.51×10−7 M) clearly characterized the histaminic activation as being of the H2 type. It is suggested that these two vasoactive hormones may operate as neurocrine/paracrine regulators of the differentiation and/or function of the human gastric mucosa in utero.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02118640
Permalink